| ŠÁNA, Jiří, Lenka RADOVÁ, Radek LAKOMÝ, Leoš KŘEN, Pavel FADRUS, Martin SMRČKA, Andrej BEŠŠE, Jana NEKVINDOVÁ, Markéta HERMANOVÁ, Radim JANČÁLEK, Marek SVOBODA, Marian HAJDÚCH, Pavel ŠLAMPA, Rostislav VYZULA a Ondřej SLABÝ. Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients. Carcinogenesis. Oxford: Oxford University Press, 2014, roč. 35, č. 12, s. 2756-2762. ISSN 0143-3334. Dostupné z: https://dx.doi.org/10.1093/carcin/bgu212. |
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@article{1206178,
author = {Šána, Jiří and Radová, Lenka and Lakomý, Radek and Křen, Leoš and Fadrus, Pavel and Smrčka, Martin and Bešše, Andrej and Nekvindová, Jana and Hermanová, Markéta and Jančálek, Radim and Svoboda, Marek and Hajdúch, Marian and Šlampa, Pavel and Vyzula, Rostislav and Slabý, Ondřej},
article_location = {Oxford},
article_number = {12},
doi = {http://dx.doi.org/10.1093/carcin/bgu212},
keywords = {microRNA; expression profiling; glioblastoma multiforme; risc score; prognostic classifier},
language = {eng},
issn = {0143-3334},
journal = {Carcinogenesis},
title = {Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients},
volume = {35},
year = {2014}
}
TY - JOUR
ID - 1206178
AU - Šána, Jiří - Radová, Lenka - Lakomý, Radek - Křen, Leoš - Fadrus, Pavel - Smrčka, Martin - Bešše, Andrej - Nekvindová, Jana - Hermanová, Markéta - Jančálek, Radim - Svoboda, Marek - Hajdúch, Marian - Šlampa, Pavel - Vyzula, Rostislav - Slabý, Ondřej
PY - 2014
TI - Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients
JF - Carcinogenesis
VL - 35
IS - 12
SP - 2756-2762
EP - 2756-2762
PB - Oxford University Press
SN - 01433334
KW - microRNA
KW - expression profiling
KW - glioblastoma multiforme
KW - risc score
KW - prognostic classifier
N2 - Glioblastoma multiforme (GBM) is the most malignant primary brain tumor. The prognosis of GBM patients varies considerably and the histopathological examination is not sufficient for individual risk estimation. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression and were repeatedly proved to play important roles in pathogenesis of GBM. In our study, we performed global miRNA expression profiling of 58 glioblastoma tissue samples obtained during surgical resections and 10 non-tumor brain tissues. The subsequent analysis revealed 28 significantly deregulated miRNAs in GBM tissue, which were able to precisely classify all examined samples. Correlation with clinical data led to identification of six-miRNA signature significantly associated with progression free survival [hazard ratio (HR) 1.98, 95% confidence interval (CI) 1.33-2.94, P < 0.001] and overa+ll survival (HR 2.86, 95% CI 1.91-4.29, P < 0.001). O(6)-methylguanine-DNA methyltransferase methylation status was evaluated as reference method and Risk Score based on six-miRNA signature indicated significant superiority in prediction of clinical outcome in GBM patients. Multivariate Cox analysis indicated that the Risk Score based on six-miRNA signature is an independent prognostic classifier of GBM patients. We suggest that the Risk Score presents promising prognostic algorithm with potential for individualized treatment decisions in clinical management of GBM patients.
ER -
ŠÁNA, Jiří, Lenka RADOVÁ, Radek LAKOMÝ, Leoš KŘEN, Pavel FADRUS, Martin SMRČKA, Andrej BEŠŠE, Jana NEKVINDOVÁ, Markéta HERMANOVÁ, Radim JANČÁLEK, Marek SVOBODA, Marian HAJDÚCH, Pavel ŠLAMPA, Rostislav VYZULA a Ondřej SLABÝ. Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients. \textit{Carcinogenesis}. Oxford: Oxford University Press, 2014, roč.~35, č.~12, s.~2756-2762. ISSN~0143-3334. Dostupné z: https://dx.doi.org/10.1093/carcin/bgu212.
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