Characterization of Human Uropathogenic ESBL-Producing
Escherichia coli in the Czech Republic: Spread of
CTX-M-27-Producing Strains in a University Hospital

J 2014

Characterization of Human Uropathogenic ESBL-Producing Escherichia coli in the Czech Republic: Spread of CTX-M-27-Producing Strains in a University Hospital

MICENKOVÁ, Lenka, Petra ŠIŠKOVÁ, Juraj BOSÁK, Ivana JAMBOROVÁ, Lenka ČERNOHORSKÁ et. al.

Základní údaje

Originální název

Characterization of Human Uropathogenic ESBL-Producing Escherichia coli in the Czech Republic: Spread of CTX-M-27-Producing Strains in a University Hospital

Autoři

MICENKOVÁ, Lenka (703 Slovensko, domácí), Petra ŠIŠKOVÁ (203 Česká republika, domácí), Juraj BOSÁK (703 Slovensko, domácí), Ivana JAMBOROVÁ (203 Česká republika), Lenka ČERNOHORSKÁ (203 Česká republika, domácí) a David ŠMAJS (203 Česká republika, garant, domácí)

Vydání

Microbial Drug Resistance, New Rochelle, Mary Ann Liebert Inc. 2014, 1076-6294

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.490

Kód RIV

RIV/00216224:14110/14:00080150

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1089/mdr.2014.0013

UT WoS

000345616200015

Klíčová slova anglicky

SPECTRUM BETA-LACTAMASES; CTX-M-TYPE; FIELD GEL-ELECTROPHORESIS; POLYMERASE-CHAIN-REACTION; URINARY-TRACT-INFECTIONS; MOLECULAR EPIDEMIOLOGY; VIRULENCE DETERMINANTS; ANTIBIOTIC-RESISTANCE; KLEBSIELLA-PNEUMONIAE; PHYLOGENETIC GROUP

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 22. 1. 2015 09:34, Soňa Böhmová

Anotace

V originále

Aims: The purpose of this study was to characterize the extended-spectrum b-lactamase (ESBL)-producing uropathogenic Escherichia coli (UPEC) strains isolated in the South Moravia region of the Czech Republic. Results: Out of 109 ESBL-producing UPEC isolates, the CTX-M-15-producing E. coli O25b-ST131 was detected in 55 (50.5%) and the CTX-M-27-producing E. coli O25b-ST131 in 40 isolates (36.7%). Most isolates were distributed among three pulsed-field gel electrophoresis clusters and were characterized by low variability relative to antibiotic resistance patterns, in E. coli phylogroups and by the prevalence of virulence and bacteriocin determinants. Despite this, 14 groups of identical isolates (comprising a total of 41 isolates) were identified when all tested parameters of E. coli were combined. Conclusions: Since the occurrence of E. coli B2-O25b-ST131 CTX-M-27 was only recently described in Asia, the frequent isolation of this lineage among patients in South Moravia suggests an efficient transfer of this clone from Asian countries. The limited variability of detected parameters of ESBL-producing UPEC strains is consistent with a common origin of the analyzed isolates, in which there is an ongoing process of genetic diversification.

Návaznosti

NT13413, projekt VaV

Název: Stanovení apoptózy v biopticky odebraných vzorcích z tlustého střeva

Investor: Ministerstvo zdravotnictví ČR, Stanovení apoptózy v biopticky odebraných vzorcích z tlustého střeva

Citovat

MICENKOVÁ, Lenka, Petra ŠIŠKOVÁ, Juraj BOSÁK, Ivana JAMBOROVÁ, Lenka ČERNOHORSKÁ a David ŠMAJS. Characterization of Human Uropathogenic ESBL-Producing Escherichia coli in the Czech Republic: Spread of CTX-M-27-Producing Strains in a University Hospital. Microbial Drug Resistance. New Rochelle: Mary Ann Liebert Inc., 2014, roč. 20, č. 6, s. 610-617. ISSN 1076-6294. Dostupné z: https://dx.doi.org/10.1089/mdr.2014.0013.

@article{1209760,
   author = {Micenková, Lenka and Šišková, Petra and Bosák, Juraj and Jamborová, Ivana and Černohorská, Lenka and Šmajs, David},
   article_location = {New Rochelle},
   article_number = {6},
   doi = {http://dx.doi.org/10.1089/mdr.2014.0013},
   keywords = {SPECTRUM BETA-LACTAMASES; CTX-M-TYPE; FIELD GEL-ELECTROPHORESIS; POLYMERASE-CHAIN-REACTION; URINARY-TRACT-INFECTIONS; MOLECULAR EPIDEMIOLOGY; VIRULENCE DETERMINANTS; ANTIBIOTIC-RESISTANCE; KLEBSIELLA-PNEUMONIAE; PHYLOGENETIC GROUP},
   language = {eng},
   issn = {1076-6294},
   journal = {Microbial Drug Resistance},
   title = {Characterization of Human Uropathogenic ESBL-Producing Escherichia coli in the Czech Republic: Spread of CTX-M-27-Producing Strains in a University Hospital},
   volume = {20},
   year = {2014}
}

TY  - JOUR
ID  - 1209760
AU  - Micenková, Lenka - Šišková, Petra - Bosák, Juraj - Jamborová, Ivana - Černohorská, Lenka - Šmajs, David
PY  - 2014
TI  - Characterization of Human Uropathogenic ESBL-Producing Escherichia coli in the Czech Republic: Spread of CTX-M-27-Producing Strains in a University Hospital
JF  - Microbial Drug Resistance
VL  - 20
IS  - 6
SP  - 610-617
EP  - 610-617
PB  - Mary Ann Liebert Inc.
SN  - 10766294
KW  - SPECTRUM BETA-LACTAMASES
KW  - CTX-M-TYPE
KW  - FIELD GEL-ELECTROPHORESIS
KW  - POLYMERASE-CHAIN-REACTION
KW  - URINARY-TRACT-INFECTIONS
KW  - MOLECULAR EPIDEMIOLOGY
KW  - VIRULENCE DETERMINANTS
KW  - ANTIBIOTIC-RESISTANCE
KW  - KLEBSIELLA-PNEUMONIAE
KW  - PHYLOGENETIC GROUP
N2  - Aims: The purpose of this study was to characterize the extended-spectrum b-lactamase (ESBL)-producing uropathogenic Escherichia coli (UPEC) strains isolated in the South Moravia region of the Czech Republic. Results: Out of 109 ESBL-producing UPEC isolates, the CTX-M-15-producing E. coli O25b-ST131 was detected in 55 (50.5%) and the CTX-M-27-producing E. coli O25b-ST131 in 40 isolates (36.7%). Most isolates were distributed among three pulsed-field gel electrophoresis clusters and were characterized by low variability relative to antibiotic resistance patterns, in E. coli phylogroups and by the prevalence of virulence and bacteriocin determinants. Despite this, 14 groups of identical isolates (comprising a total of 41 isolates) were identified when all tested parameters of E. coli were combined. Conclusions: Since the occurrence of E. coli B2-O25b-ST131 CTX-M-27 was only recently described in Asia, the frequent isolation of this lineage among patients in South Moravia suggests an efficient transfer of this clone from Asian countries. The limited variability of detected parameters of ESBL-producing UPEC strains is consistent with a common origin of the analyzed isolates, in which there is an ongoing process of genetic diversification.
ER  -

MICENKOVÁ, Lenka, Petra ŠIŠKOVÁ, Juraj BOSÁK, Ivana JAMBOROVÁ, Lenka ČERNOHORSKÁ a David ŠMAJS. Characterization of Human Uropathogenic ESBL-Producing Escherichia coli in the Czech Republic: Spread of CTX-M-27-Producing Strains in a University Hospital. \textit{Microbial Drug Resistance}. New Rochelle: Mary Ann Liebert Inc., 2014, roč.~20, č.~6, s.~610-617. ISSN~1076-6294. Dostupné z: https://dx.doi.org/10.1089/mdr.2014.0013.

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