2014
Thiamine Metabolism Alterations in Gestational Diabetes Complicated Pregnancy
BARTÁKOVÁ, Vendula, Anna PLESKAČOVÁ, Roman KUDLÁČ, Katarína KURICOVÁ, Veronika DVOŘÁKOVÁ et. al.Základní údaje
Originální název
Thiamine Metabolism Alterations in Gestational Diabetes Complicated Pregnancy
Autoři
BARTÁKOVÁ, Vendula, Anna PLESKAČOVÁ, Roman KUDLÁČ, Katarína KURICOVÁ, Veronika DVOŘÁKOVÁ, Jana BĚLOBRÁDKOVÁ, Josef TOMANDL, Marie TOMANDLOVÁ, Lukáš PÁCAL a Kateřina KAŇKOVÁ
Vydání
The 3rd Annual World Congress of Diabetes 2014 (WCD-2014), Haikou, China, 2014
Další údaje
Typ výsledku
Prezentace na konferencích
Utajení
není předmětem státního či obchodního tajemství
Klíčová slova česky
tiamin, vitamín B1, gestační diabetes, těhotenství
Klíčová slova anglicky
gestational diabetes mellitus, pregnancy, thiamine
Změněno: 20. 11. 2014 09:20, MUDr. Vendula Bartáková, Ph.D.
Anotace
V originále
Thiamine is involved in the regulation of glucose metabolism. Thiamine is delivered to the cell via specific thiamine transporters 1 (THTR1 and 2 (THTR2). Within the cell thiamine is activated by enzyme thiamine pyrophosphokinase (TPK1). Transketolase (TKT) is the rate-limiting enzyme of non-oxidative branch of pentose phosphate pathway whose activity depends on thiamine diphosphate (TDP) as a cofactor. We aimed to determine plasma thiamine levels, levels of TDP in erythrocytes, erythrocyte TKT activity and thiamine effect in pregnant women with and without GDM. A total of 181 pregnant women were included in the study. Of those 104 had GDM, 77 had physiologic pregnancy. No significant difference in plasma thiamine levels between GDM and physiologic pregnancy group was found in pregnancy and after delivery (both P 0.05, Mann-Whitney test). Plasma thiamine levels in pregnancy were significantly lower than postpartum in both GDM and physiologic pregnancy group (P < 0.001 and P = 0.017, Wilcoxon test). Erythrocyte TDP in pregnancy was significantly higher in GDM patients compared to physiologic pregnancy group (P < 0.001, Mann-Whitney), however it did not differ postpartum (P 0.05, Mann-Whitney). Mid trimester erythrocyte TDP levels were significantly higher compared to postpartum in GDM (P < 0.001, Wilcoxon test) as well as in physiologic pregnancy group (P < 0.001, Wilcoxon paired test). Both GDM complicated and physiologic pregnancy are characterized by increase in erythrocyte TDP accompanied by parallel decrease in plasma thiamine during second trimester compared to postpartum. GDM is associated with significantly increased level of active form of thiamine (TDP) in erythrocytes during second trimester compared to physiologic pregnancy. However, TDP levels are normalised postpartum.
Návaznosti
NT11405, projekt VaV |
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