Small-nerve-fiber pathology in critical illness documented by
serial skin biopsies

J 2015

Small-nerve-fiber pathology in critical illness documented by serial skin biopsies

ŠKORŇA, Miroslav, Roman KOPÁČIK, Eva VLČKOVÁ, Blanka ADAMOVÁ, Milena KOŠŤÁLOVÁ et. al.

Základní údaje

Originální název

Small-nerve-fiber pathology in critical illness documented by serial skin biopsies

Autoři

ŠKORŇA, Miroslav (203 Česká republika, garant, domácí), Roman KOPÁČIK (703 Slovensko, domácí), Eva VLČKOVÁ (203 Česká republika, domácí), Blanka ADAMOVÁ (203 Česká republika, domácí), Milena KOŠŤÁLOVÁ (203 Česká republika, domácí) a Josef BEDNAŘÍK (203 Česká republika, domácí)

Vydání

Muscle & nerve, New York, Wiley-Blackwell, 2015, 0148-639X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.713

Kód RIV

RIV/00216224:14110/15:00082172

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/mus.24489

UT WoS

000356498000005

Klíčová slova anglicky

critical illness; small fibers; polyneuropathy; myopathy; skin biopsy

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 7. 2015 10:52, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Introduction: Small fiber pathology can develop in the acute phase of critical illness and may explain chronic sensory impairment and pain in critical care survivors. Methods: Eleven adult ischemic stroke patients in a neurocritical care unit were enrolled in an observational cohort study. Intraepidermal never fiber density (IENFD) in the distal leg was assessed on admission to the intensive care unit and 10-14 days later, together with electrophysiological testing. Results: Of the 11 patients recruited, 9 (82%) had sepsis or multiple organ failure. Median IENFD on admission (5.05 fibers/mm) decreased significantly to 2.18 fibers/mm (P <0.001), and abnormal IENFD was found in 8 patients (72.7%). Electrodiagnostic signs of large fiber neuropathy and/or myopathy were found in 6 patients (54.5%), and autonomic dysfunction was found in 2 patients (18.2%). Discussion: Serial IENFD measurements confirmed the development of small fiber sensory involvement in the acute phase of critical illness.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

MUNI/A/0935/2013, interní kód MU

Název: Diagnostika a patofyziologie neuropatické bolesti

Investor: Masarykova univerzita, Diagnostika a patofyziologie neuropatické bolesti, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Přiložené soubory

EL_1209965.pdf

Požádat o autorskou verzi souboru

Citovat

ŠKORŇA, Miroslav, Roman KOPÁČIK, Eva VLČKOVÁ, Blanka ADAMOVÁ, Milena KOŠŤÁLOVÁ a Josef BEDNAŘÍK. Small-nerve-fiber pathology in critical illness documented by serial skin biopsies. Muscle & nerve. New York: Wiley-Blackwell, 2015, roč. 52, č. 1, s. 28-33. ISSN 0148-639X. Dostupné z: https://dx.doi.org/10.1002/mus.24489.

@article{1209965,
   author = {Škorňa, Miroslav and Kopáčik, Roman and Vlčková, Eva and Adamová, Blanka and Košťálová, Milena and Bednařík, Josef},
   article_location = {New York},
   article_number = {1},
   doi = {http://dx.doi.org/10.1002/mus.24489},
   keywords = {critical illness; small fibers; polyneuropathy; myopathy; skin biopsy},
   language = {eng},
   issn = {0148-639X},
   journal = {Muscle & nerve},
   note = {http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291097-4598/issues},
   title = {Small-nerve-fiber pathology in critical illness documented by serial skin biopsies},
   volume = {52},
   year = {2015}
}

TY  - JOUR
ID  - 1209965
AU  - Škorňa, Miroslav - Kopáčik, Roman - Vlčková, Eva - Adamová, Blanka - Košťálová, Milena - Bednařík, Josef
PY  - 2015
TI  - Small-nerve-fiber pathology in critical illness documented by serial skin biopsies
JF  - Muscle & nerve
VL  - 52
IS  - 1
SP  - 28-33
EP  - 28-33
PB  - Wiley-Blackwell
SN  - 0148639X
N1  - http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291097-4598/issues
KW  - critical illness
KW  - small fibers
KW  - polyneuropathy
KW  - myopathy
KW  - skin biopsy
N2  - Introduction: Small fiber pathology can develop in the acute phase of critical illness and may explain chronic sensory impairment and pain in critical care survivors. Methods: Eleven adult ischemic stroke patients in a neurocritical care unit were enrolled in an observational cohort study. Intraepidermal never fiber density (IENFD) in the distal leg was assessed on admission to the intensive care unit and 10-14 days later, together with electrophysiological testing. Results: Of the 11 patients recruited, 9 (82%) had sepsis or multiple organ failure. Median IENFD on admission (5.05 fibers/mm) decreased significantly to 2.18 fibers/mm (P <0.001), and abnormal IENFD was found in 8 patients (72.7%). Electrodiagnostic signs of large fiber neuropathy and/or myopathy were found in 6 patients (54.5%), and autonomic dysfunction was found in 2 patients (18.2%). Discussion: Serial IENFD measurements confirmed the development of small fiber sensory involvement in the acute phase of critical illness.
ER  -

ŠKORŇA, Miroslav, Roman KOPÁČIK, Eva VLČKOVÁ, Blanka ADAMOVÁ, Milena KOŠŤÁLOVÁ a Josef BEDNAŘÍK. Small-nerve-fiber pathology in critical illness documented by serial skin biopsies. \textit{Muscle \&{} nerve}. New York: Wiley-Blackwell, 2015, roč.~52, č.~1, s.~28-33. ISSN~0148-639X. Dostupné z: https://dx.doi.org/10.1002/mus.24489.

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