| ŠKORŇA, Miroslav, Roman KOPÁČIK, Eva VLČKOVÁ, Blanka ADAMOVÁ, Milena KOŠŤÁLOVÁ a Josef BEDNAŘÍK. Small-nerve-fiber pathology in critical illness documented by serial skin biopsies. Muscle & nerve. New York: Wiley-Blackwell, 2015, roč. 52, č. 1, s. 28-33. ISSN 0148-639X. Dostupné z: https://dx.doi.org/10.1002/mus.24489. |
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@article{1209965,
author = {Škorňa, Miroslav and Kopáčik, Roman and Vlčková, Eva and Adamová, Blanka and Košťálová, Milena and Bednařík, Josef},
article_location = {New York},
article_number = {1},
doi = {http://dx.doi.org/10.1002/mus.24489},
keywords = {critical illness; small fibers; polyneuropathy; myopathy; skin biopsy},
language = {eng},
issn = {0148-639X},
journal = {Muscle & nerve},
note = {http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291097-4598/issues},
title = {Small-nerve-fiber pathology in critical illness documented by serial skin biopsies},
volume = {52},
year = {2015}
}
TY - JOUR
ID - 1209965
AU - Škorňa, Miroslav - Kopáčik, Roman - Vlčková, Eva - Adamová, Blanka - Košťálová, Milena - Bednařík, Josef
PY - 2015
TI - Small-nerve-fiber pathology in critical illness documented by serial skin biopsies
JF - Muscle & nerve
VL - 52
IS - 1
SP - 28-33
EP - 28-33
PB - Wiley-Blackwell
SN - 0148639X
N1 - http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291097-4598/issues
KW - critical illness
KW - small fibers
KW - polyneuropathy
KW - myopathy
KW - skin biopsy
N2 - Introduction: Small fiber pathology can develop in the acute phase of critical illness and may explain chronic sensory impairment and pain in critical care survivors. Methods: Eleven adult ischemic stroke patients in a neurocritical care unit were enrolled in an observational cohort study. Intraepidermal never fiber density (IENFD) in the distal leg was assessed on admission to the intensive care unit and 10-14 days later, together with electrophysiological testing. Results: Of the 11 patients recruited, 9 (82%) had sepsis or multiple organ failure. Median IENFD on admission (5.05 fibers/mm) decreased significantly to 2.18 fibers/mm (P <0.001), and abnormal IENFD was found in 8 patients (72.7%). Electrodiagnostic signs of large fiber neuropathy and/or myopathy were found in 6 patients (54.5%), and autonomic dysfunction was found in 2 patients (18.2%). Discussion: Serial IENFD measurements confirmed the development of small fiber sensory involvement in the acute phase of critical illness.
ER -
ŠKORŇA, Miroslav, Roman KOPÁČIK, Eva VLČKOVÁ, Blanka ADAMOVÁ, Milena KOŠŤÁLOVÁ a Josef BEDNAŘÍK. Small-nerve-fiber pathology in critical illness documented by serial skin biopsies. \textit{Muscle \&{} nerve}. New York: Wiley-Blackwell, 2015, roč.~52, č.~1, s.~28-33. ISSN~0148-639X. Dostupné z: https://dx.doi.org/10.1002/mus.24489.
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