ŠKORŇA, Miroslav, Roman KOPÁČIK, Eva VLČKOVÁ, Blanka ADAMOVÁ, Milena KOŠŤÁLOVÁ and Josef BEDNAŘÍK. Small-nerve-fiber pathology in critical illness documented by serial skin biopsies. Muscle & nerve. New York: Wiley-Blackwell, 2015, vol. 52, No 1, p. 28-33. ISSN 0148-639X. Available from: https://dx.doi.org/10.1002/mus.24489. |
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@article{1209965, author = {Škorňa, Miroslav and Kopáčik, Roman and Vlčková, Eva and Adamová, Blanka and Košťálová, Milena and Bednařík, Josef}, article_location = {New York}, article_number = {1}, doi = {http://dx.doi.org/10.1002/mus.24489}, keywords = {critical illness; small fibers; polyneuropathy; myopathy; skin biopsy}, language = {eng}, issn = {0148-639X}, journal = {Muscle & nerve}, note = {http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291097-4598/issues}, title = {Small-nerve-fiber pathology in critical illness documented by serial skin biopsies}, volume = {52}, year = {2015} }
TY - JOUR ID - 1209965 AU - Škorňa, Miroslav - Kopáčik, Roman - Vlčková, Eva - Adamová, Blanka - Košťálová, Milena - Bednařík, Josef PY - 2015 TI - Small-nerve-fiber pathology in critical illness documented by serial skin biopsies JF - Muscle & nerve VL - 52 IS - 1 SP - 28-33 EP - 28-33 PB - Wiley-Blackwell SN - 0148639X N1 - http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291097-4598/issues KW - critical illness KW - small fibers KW - polyneuropathy KW - myopathy KW - skin biopsy N2 - Introduction: Small fiber pathology can develop in the acute phase of critical illness and may explain chronic sensory impairment and pain in critical care survivors. Methods: Eleven adult ischemic stroke patients in a neurocritical care unit were enrolled in an observational cohort study. Intraepidermal never fiber density (IENFD) in the distal leg was assessed on admission to the intensive care unit and 10-14 days later, together with electrophysiological testing. Results: Of the 11 patients recruited, 9 (82%) had sepsis or multiple organ failure. Median IENFD on admission (5.05 fibers/mm) decreased significantly to 2.18 fibers/mm (P <0.001), and abnormal IENFD was found in 8 patients (72.7%). Electrodiagnostic signs of large fiber neuropathy and/or myopathy were found in 6 patients (54.5%), and autonomic dysfunction was found in 2 patients (18.2%). Discussion: Serial IENFD measurements confirmed the development of small fiber sensory involvement in the acute phase of critical illness. ER -
ŠKORŇA, Miroslav, Roman KOPÁČIK, Eva VLČKOVÁ, Blanka ADAMOVÁ, Milena KOŠŤÁLOVÁ and Josef BEDNAŘÍK. Small-nerve-fiber pathology in critical illness documented by serial skin biopsies. \textit{Muscle \&{} nerve}. New York: Wiley-Blackwell, 2015, vol.~52, No~1, p.~28-33. ISSN~0148-639X. Available from: https://dx.doi.org/10.1002/mus.24489.
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