ŠKORŇA, Miroslav, Roman KOPÁČIK, Eva VLČKOVÁ, Blanka ADAMOVÁ, Milena KOŠŤÁLOVÁ and Josef BEDNAŘÍK. Small-nerve-fiber pathology in critical illness documented by serial skin biopsies. Muscle & nerve. New York: Wiley-Blackwell, 2015, vol. 52, No 1, p. 28-33. ISSN 0148-639X. Available from: https://dx.doi.org/10.1002/mus.24489.
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Basic information
Original name Small-nerve-fiber pathology in critical illness documented by serial skin biopsies
Authors ŠKORŇA, Miroslav (203 Czech Republic, guarantor, belonging to the institution), Roman KOPÁČIK (703 Slovakia, belonging to the institution), Eva VLČKOVÁ (203 Czech Republic, belonging to the institution), Blanka ADAMOVÁ (203 Czech Republic, belonging to the institution), Milena KOŠŤÁLOVÁ (203 Czech Republic, belonging to the institution) and Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution).
Edition Muscle & nerve, New York, Wiley-Blackwell, 2015, 0148-639X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.713
RIV identification code RIV/00216224:14110/15:00082172
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1002/mus.24489
UT WoS 000356498000005
Keywords in English critical illness; small fibers; polyneuropathy; myopathy; skin biopsy
Tags EL OK, podil
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 24/7/2015 10:52.
Abstract
Introduction: Small fiber pathology can develop in the acute phase of critical illness and may explain chronic sensory impairment and pain in critical care survivors. Methods: Eleven adult ischemic stroke patients in a neurocritical care unit were enrolled in an observational cohort study. Intraepidermal never fiber density (IENFD) in the distal leg was assessed on admission to the intensive care unit and 10-14 days later, together with electrophysiological testing. Results: Of the 11 patients recruited, 9 (82%) had sepsis or multiple organ failure. Median IENFD on admission (5.05 fibers/mm) decreased significantly to 2.18 fibers/mm (P <0.001), and abnormal IENFD was found in 8 patients (72.7%). Electrodiagnostic signs of large fiber neuropathy and/or myopathy were found in 6 patients (54.5%), and autonomic dysfunction was found in 2 patients (18.2%). Discussion: Serial IENFD measurements confirmed the development of small fiber sensory involvement in the acute phase of critical illness.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
MUNI/A/0935/2013, interní kód MUName: Diagnostika a patofyziologie neuropatické bolesti
Investor: Masaryk University, Category A
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