J 2014

The role of the TP73 gene and its transcripts in neuro-oncology

JANČÁLEK, Radim

Základní údaje

Originální název

The role of the TP73 gene and its transcripts in neuro-oncology

Autoři

JANČÁLEK, Radim (203 Česká republika, garant, domácí)

Vydání

British journal of neurosurgery, London, Informa Healthcare, 2014, 0268-8697

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.960

Kód RIV

RIV/00216224:14110/14:00077492

Organizační jednotka

Lékařská fakulta

DOI

UT WoS

000341753500004

Klíčová slova anglicky

gliomagenesis; isoforms; TP73 gene; p73 protein

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 27. 11. 2014 14:52, Soňa Böhmová

Anotace

V originále

Protein p73 is a member of the p53 protein family that can induce cell cycle arrest or apoptosis by the activation of p53-responsive genes as well as p53-independent pathways. Alternative promoter usage, together with differential splicing of the C-terminal exons, forms several distinct mRNAs that are translated into corresponding protein isoforms containing different domains. While TAp73 isoforms respond to genotoxic stress in a manner similar to tumor suppressor p53, Delta TAp73 isoforms inhibit apoptosis during normal development and in cancer cell lines. Thus, the impact of p73 on tumorigenesis depends on a subtle balance between tumor-promoting and-suppressing isoforms. Due to the structural homology between p53 and p73, a subtle balance among p53 family members and their isoforms could influence glioma cell evolution toward malignancy. Thus, the p73 status has to be considered when studying the regulatory role of p53 protein in gliomagenesis. The presented review summarizes recent knowledge about the issue of p73 and its isoforms with respect to neuro-oncology research.