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@article{1210647,
author = {Jančálek, Radim},
article_location = {London},
article_number = {5},
doi = {http://dx.doi.org/10.3109/02688697.2014.908162},
keywords = {gliomagenesis; isoforms; TP73 gene; p73 protein},
language = {eng},
issn = {0268-8697},
journal = {British journal of neurosurgery},
title = {The role of the TP73 gene and its transcripts in neuro-oncology},
volume = {28},
year = {2014}
}
TY - JOUR
ID - 1210647
AU - Jančálek, Radim
PY - 2014
TI - The role of the TP73 gene and its transcripts in neuro-oncology
JF - British journal of neurosurgery
VL - 28
IS - 5
SP - 598-605
EP - 598-605
PB - Informa Healthcare
SN - 02688697
KW - gliomagenesis
KW - isoforms
KW - TP73 gene
KW - p73 protein
N2 - Protein p73 is a member of the p53 protein family that can induce cell cycle arrest or apoptosis by the activation of p53-responsive genes as well as p53-independent pathways. Alternative promoter usage, together with differential splicing of the C-terminal exons, forms several distinct mRNAs that are translated into corresponding protein isoforms containing different domains. While TAp73 isoforms respond to genotoxic stress in a manner similar to tumor suppressor p53, Delta TAp73 isoforms inhibit apoptosis during normal development and in cancer cell lines. Thus, the impact of p73 on tumorigenesis depends on a subtle balance between tumor-promoting and-suppressing isoforms. Due to the structural homology between p53 and p73, a subtle balance among p53 family members and their isoforms could influence glioma cell evolution toward malignancy. Thus, the p73 status has to be considered when studying the regulatory role of p53 protein in gliomagenesis. The presented review summarizes recent knowledge about the issue of p73 and its isoforms with respect to neuro-oncology research.
ER -
JANČÁLEK, Radim. The role of the TP73 gene and its transcripts in neuro-oncology. \textit{British journal of neurosurgery}. London: Informa Healthcare, 2014, roč.~28, č.~5, s.~598-605. ISSN~0268-8697. Dostupné z: https://dx.doi.org/10.3109/02688697.2014.908162.
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