HEL, Zdenek, Richard P. H. HUIJBREGTS, Jun XU, Jana NECHVÁTALOVÁ, Marcela VLKOVÁ and Jiří LITZMAN. Altered Serum Cytokine Signature in Common Variable Immunodeficiency. Journal of Clinical Immunology. New York: Springer, 2014, vol. 34, No 8, p. 971-978. ISSN 0271-9142. doi:10.1007/s10875-014-0099-z.
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Basic information
Original name Altered Serum Cytokine Signature in Common Variable Immunodeficiency
Authors HEL, Zdenek (840 United States of America), Richard P. H. HUIJBREGTS (840 United States of America), Jun XU (840 United States of America), Jana NECHVÁTALOVÁ (203 Czech Republic, belonging to the institution), Marcela VLKOVÁ (203 Czech Republic, belonging to the institution) and Jiří LITZMAN (203 Czech Republic, guarantor, belonging to the institution).
Edition Journal of Clinical Immunology, New York, Springer, 2014, 0271-9142.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30102 Immunology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.184
RIV identification code RIV/00216224:14110/14:00077503
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1007/s10875-014-0099-z
UT WoS 000344780000012
Keywords in English Common variable immunodeficiency; IgA deficiency; cytokine; lymphocyte activation
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 24/4/2015 13:56.
Abstract
Purpose Common variable immunodeficiency (CVID) is the most frequent form of primary symptomatic hypogammaglobulinemia. CVID patients display a number of abnormalities in lymphocyte subpopulations including chronic T-cell activation and decreased numbers of circulating CD4+ T cells and NK cells. We and others have recently shown that CVID is associated with increased concentration of soluble CD14 (sCD14) and other factors indicating limited microbial translocation. Methods To address the mechanisms of chronic immune activation in CVID, we performed a detailed analysis of cytokine serum levels in 36 patients with CVID, 52 patients with selective IgA deficiency (IgAD), and 56 healthy volunteers. Results We show that CVID is associated with elevated serum levels of CXCL-10/IP-10, IL-1R antagonist, TNF-alpha, IL-10, IL-12 (p40), CCL-2/MCP-1, G-CSF, and CCL-11/eotaxin. The detected cytokine signature is consistent with an ongoing activation of cells of myeloid lineage. In contrast, the levels of cytokines typically produced by CD4+ T helper cells of Th1 (IFN-y, IL-2), Th2 (IL-9, IL-13), and Th17 (IL-17) subtypes were suppressed in CVID patients compared to healthy donors. Conclusions Presented data suggest that the altered cytokine profile observed in patients with CVID may be attributed to the activation of monocyte-macrophage and granulocyte lineages, possibly driven by the translocation of bacterial components across the gastrointestinal or respiratory tracts mucosal barrier.
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