Uncultivable Pathogenic Treponemes

C 2015

Uncultivable Pathogenic Treponemes

ŠMAJS, David a Michal STROUHAL

Základní údaje

Originální název

Uncultivable Pathogenic Treponemes

Autoři

ŠMAJS, David (203 Česká republika, garant, domácí) a Michal STROUHAL (203 Česká republika, domácí)

Vydání

2nd ed. Amsterdam, Molecular Medical Microbiology. Vol. 3, od s. 1421-1436, 16 s. 2015

Nakladatel

Elsevier Science Ltd.

Další údaje

Jazyk

angličtina

Typ výsledku

Kapitola resp. kapitoly v odborné knize

Obor

10600 1.6 Biological sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

tištěná verze "print"

Kód RIV

RIV/00216224:14110/15:00080615

Organizační jednotka

Lékařská fakulta

ISBN

978-0-12-397169-2

DOI

http://dx.doi.org/10.1016/B978-0-12-397169-2.00079-2

Klíčová slova anglicky

bejel; endemic treponematoses; pinta; syphilis; Treponema carateum; Treponema pallidum subsp. endemicum; T. pallidum subsp. pallidum; T. pallidum subsp. pertenue; T. paraluiscuniculi; yaws

Štítky

EL OK

Změněno: 17. 12. 2014 16:22, Soňa Böhmová

Anotace

V originále

Uncultivable pathogenic treponemes represent bacterial species and subspecies that are obligate pathogens of humans and animals. Treponema pallidum subsp. pallidum causes sexually transmitted syphilis, a multistage disease characterized in humans by localized, disseminated, and chronic forms of infection. Causative agents of endemic treponematoses comprise Treponema pallidum subsp. pertenue (agent of yaws), Treponema pallidum subsp. endemicum (agent of bejel) and T. carateum (agent of pinta) causing milder, non-venereal transmitted diseases affecting skin, bones and joints. Closely related treponemes, simian Treponema Fribourg-Blanc and T. paraluiscuniculi, cause infections in non-human primates and rabbits, respectively. T. paraluiscuniculi is not pathogenic to humans, whereas simian Treponema Fribourg-Blanc has been shown to cause experimental human infections. All human treponematoses share remarkable similarities in pathogenesis and clinical manifestations, consistent with the high genetic and antigenic relatedness of their aetiological agents. Pathogenic treponemes are characterized by low toxicity, high invasiveness, and high immuno-evasiveness. Moreover, treponemes are pathogens able to infect almost any type of human tissues, i.e. showing broad tissue tropism. All these pathogenic treponemes cannot be continuously cultivated under in vitro conditions. All uncultivable pathogenic treponemes have a reduced genome (~1.14 Mb) and represent clonal bacteria with identical genome structure having only minimal genetic differences in their genomic sequences.

Návaznosti

EE2.3.30.0009, projekt VaV

Název: Zaměstnáním čerstvých absolventů doktorského studia k vědecké excelenci

GA310/07/0321, projekt VaV

Název: Komparativní genomové sekvencování patogenních treponem a transkriptomová analýza T. pallidum ssp. pallidum

Investor: Grantová agentura ČR, Komparativní genomové sekvencování patogenních treponem a transkriptomová analýza T. pallidum ssp. pallidum

NT11159, projekt VaV

Název: Mapování výskytu makrolidové rezistence původce syfilis v ČR a molekulární typizace jednotlivých syfilitických kmenů

Investor: Ministerstvo zdravotnictví ČR, Mapování výskytu makrolidové rezistence původce syfilis v ČR a molekulární typizace jednotlivých syfilitických kmenů

Citovat

ŠMAJS, David a Michal STROUHAL. Uncultivable Pathogenic Treponemes. In Yi-Wei Tang, Max Sussman, Dongyou Liu, Ian Poxton, Joseph Schwartzman. Molecular Medical Microbiology. Vol. 3. 2nd ed. Amsterdam: Elsevier Science Ltd., 2015, s. 1421-1436. ISBN 978-0-12-397169-2. Dostupné z: https://dx.doi.org/10.1016/B978-0-12-397169-2.00079-2.

@inbook{1211724,
   author = {Šmajs, David and Strouhal, Michal},
   address = {Amsterdam},
   booktitle = {Molecular Medical Microbiology. Vol. 3},
   doi = {http://dx.doi.org/10.1016/B978-0-12-397169-2.00079-2},
   edition = {2nd ed.},
   editor = {Yi-Wei Tang, Max Sussman, Dongyou Liu, Ian Poxton, Joseph Schwartzman},
   keywords = {bejel; endemic treponematoses; pinta; syphilis; Treponema carateum; Treponema pallidum subsp. endemicum; T. pallidum subsp. pallidum; T. pallidum subsp. pertenue; T. paraluiscuniculi; yaws},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Amsterdam},
   isbn = {978-0-12-397169-2},
   pages = {1421-1436},
   publisher = {Elsevier Science Ltd.},
   title = {Uncultivable Pathogenic Treponemes},
   year = {2015}
}

TY  - CHAP
ID  - 1211724
AU  - Šmajs, David - Strouhal, Michal
PY  - 2015
TI  - Uncultivable Pathogenic Treponemes
VL  - Neuveden
PB  - Elsevier Science Ltd.
CY  - Amsterdam
SN  - 9780123971692
KW  - bejel
KW  - endemic treponematoses
KW  - pinta
KW  - syphilis
KW  - Treponema carateum
KW  - Treponema pallidum subsp. endemicum
KW  - T. pallidum subsp. pallidum
KW  - T. pallidum subsp. pertenue
KW  - T. paraluiscuniculi
KW  - yaws
N2  - Uncultivable pathogenic treponemes represent bacterial species and subspecies that are obligate pathogens of humans and animals. Treponema pallidum subsp. pallidum causes sexually transmitted syphilis, a multistage disease characterized in humans by localized, disseminated, and chronic forms of infection. Causative agents of endemic treponematoses comprise Treponema pallidum subsp. pertenue (agent of yaws), Treponema pallidum subsp. endemicum (agent of bejel) and T. carateum (agent of pinta) causing milder, non-venereal transmitted diseases affecting skin, bones and joints. Closely related treponemes, simian Treponema Fribourg-Blanc and T. paraluiscuniculi, cause infections in non-human primates and rabbits, respectively. T. paraluiscuniculi is not pathogenic to humans, whereas simian Treponema Fribourg-Blanc has been shown to cause experimental human infections. All human treponematoses share remarkable similarities in pathogenesis and clinical manifestations, consistent with the high genetic and antigenic relatedness of their aetiological agents. Pathogenic treponemes are characterized by low toxicity, high invasiveness, and high immuno-evasiveness. Moreover, treponemes are pathogens able to infect almost any type of human tissues, i.e. showing broad tissue tropism. All these pathogenic treponemes cannot be continuously cultivated under in vitro conditions. All uncultivable pathogenic treponemes have a reduced genome (~1.14 Mb) and represent clonal bacteria with identical genome structure having only minimal genetic differences in their genomic sequences.
ER  -

ŠMAJS, David a Michal STROUHAL. Uncultivable Pathogenic Treponemes. In Yi-Wei Tang, Max Sussman, Dongyou Liu, Ian Poxton, Joseph Schwartzman. \textit{Molecular Medical Microbiology. Vol. 3}. 2nd ed. Amsterdam: Elsevier Science Ltd., 2015, s.~1421-1436. ISBN~978-0-12-397169-2. Dostupné z: https://dx.doi.org/10.1016/B978-0-12-397169-2.00079-2.

Podrobný výpis o publikaci