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@article{1211820,
author = {Veselka, Josef and Krejčí, Jan and Tomašov, Pavol and Zemánek, David},
article_location = {Oxford},
article_number = {30},
doi = {http://dx.doi.org/10.1093/eurheartj/eht495},
keywords = {Alcohol septal ablation; Prognosis; Hypertrophic cardiomyopathy},
language = {eng},
issn = {0195-668X},
journal = {European heart journal},
title = {Long-term survival after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a comparison with general population},
volume = {35},
year = {2014}
}
TY - JOUR
ID - 1211820
AU - Veselka, Josef - Krejčí, Jan - Tomašov, Pavol - Zemánek, David
PY - 2014
TI - Long-term survival after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a comparison with general population
JF - European heart journal
VL - 35
IS - 30
SP - "2040"-"+"
EP - "2040"-"+"
PB - Oxford University Press
SN - 0195668X
KW - Alcohol septal ablation
KW - Prognosis
KW - Hypertrophic cardiomyopathy
N2 - Methods and results A total of 178 highly symptomatic, consecutive patients (58 +/- 12 years, 53% women) were treated by ASA between April 1998 and April 2013 and followed-up for 4.8 years (IQR 2.1-7.5). At baseline, 155 patients (87%) suffered from dyspnoea >= 3 class of NYHA; at the most recent examination, 87 patients (49%) and 23 patients (13%) reported dyspnoea of NYHA class 1 and >= 3, respectively. The left ventricular outflow gradient was significantly reduced (68 +/- 42 vs. 20 +/- 25 mmHg; P < 0.01). A total of 19 deaths (11%) occurred during 925 patient-years, which means an overall mortality rate of 2.1% per year. Survival free of all-cause mortality at 1, 5, and 10 years was 97% (95% CI, 93-99%), 92% (95% CI, 87-96%), and 82% (95% CI, 70-90%), respectively. This observed mortality was comparable to the expected survival for age- and sex-comparable general population (P = 0.34). According to multivariate analysis, the only independent predictor of all-cause mortality was age at ASA (hazard ratio 1.09, 95% CI 1.04-1.14; P < 0.01). Conclusions This study suggests that in patients with HOCM and important symptoms who underwent ASA, long-term survival after the procedure did not differ significantly from that of the general population.
ER -
VESELKA, Josef, Jan KREJČÍ, Pavol TOMAŠOV a David ZEMÁNEK. Long-term survival after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a comparison with general population. \textit{European heart journal}. Oxford: Oxford University Press, 2014, roč.~35, č.~30, s.~''2040''-''+'', 7 s. ISSN~0195-668X. Dostupné z: https://dx.doi.org/10.1093/eurheartj/eht495.
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