Experimental assessment of a new type of vascular prostheses
with Adiponectin (Adipograft Ra 7/350 ) on sheep

J 2014

Experimental assessment of a new type of vascular prostheses with Adiponectin (Adipograft Ra 7/350 ) on sheep

PODLAHA, Jiří and Kräuff Rainer SCHWANHAEUSER WULFF

Basic information

Original name

Experimental assessment of a new type of vascular prostheses with Adiponectin (Adipograft Ra 7/350 ) on sheep

Name in Czech

Experimentální hodnocení nového typu vaskulárních protéz s adiponektinem (Adipograft Ra 7/350 ) na ovcích

Authors

PODLAHA, Jiří (203 Czech Republic, guarantor, belonging to the institution) and Kräuff Rainer SCHWANHAEUSER WULFF (203 Czech Republic, belonging to the institution)

Edition

Acta Veterinaria-Beograd, Beograd, Faculty of Veterinary Medicine, University of Belgrade, 2014, 0567-8315

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Serbia

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 0.375

RIV identification code

RIV/00216224:14110/14:00077813

Organization unit

Faculty of Medicine

DOI

https://doi.org/10.2478/acve-2014-0040

UT WoS

000348509200003

EID Scopus

2-s2.0-84921391359

Keywords (in Czech)

adiponectin, experimentální chirurgie, preklinická studie, vaskulární protéza

Keywords in English

adiponectin; experimental surgery; preclinical trial; vascular prosthesis.

Abstract

In the original language

Despite medical advancements, the development of an ideal vascular prosthesis still poses a great challenge. In this study the researchers tried to test and verify the characteristics of a new type of vascular prosthesis, using adiponectin (Adipograft Ra 1vk 7/350) developed at the Knitting Research Institute, a.s. Brno. Two types of vascular prostheses (12 with adiponectin and 6 as a control without adiponectin) were implanted in nine healthy 4-year-old Merino sheep. The implantation site was the common carotid artery and the length of the implant was 10 cm. We applied the theory of the protected coagulum, whereby all sheep received antibiotics as a prophylactic measure. A Doppler U.S. was performed before fi nishing each operation, in order to verify the patency of the prostheses. Each animal was followed up during the whole study and the prostheses were extirpated on days 30 and 100 (1 and 3 months). It was observed that all prostheses coated with adiponectin showed patency after extirpation. The lumen implants were of a consistent thickness of 7 mm. Histological study of the implanted prostheses confi rmed a quick, high quality, healing. Experimental vascular prostheses coated with adiponectin appeared to be successful in clinical practice. The researchers think that Adipograft Ra 1vk 7/350 can be a turning point in the development of vascular prostheses, due to its patency and quick healing.

Cite

PODLAHA, Jiří and Kräuff Rainer SCHWANHAEUSER WULFF. Experimental assessment of a new type of vascular prostheses with Adiponectin (Adipograft Ra 7/350 ) on sheep. Acta Veterinaria-Beograd. Beograd: Faculty of Veterinary Medicine, University of Belgrade, 2014, vol. 64, No 4, p. 426-437. ISSN 0567-8315. Available from: https://doi.org/10.2478/acve-2014-0040.

@article{1213571,
   author = {Podlaha, Jiří and Schwanhaeuser Wulff, Kräuff Rainer},
   article_location = {Beograd},
   article_number = {4},
   doi = {https://doi.org/10.2478/acve-2014-0040},
   keywords = {adiponectin; experimental surgery; preclinical trial; vascular prosthesis.},
   language = {eng},
   issn = {0567-8315},
   journal = {Acta Veterinaria-Beograd},
   title = {Experimental assessment of a new type of vascular prostheses with Adiponectin (Adipograft Ra 7/350 ) on sheep},
   url = {http://www.actaveterinaria.rs/volume/issue/14/81/706},
   volume = {64},
   year = {2014}
}

TY  - JOUR
ID  - 1213571
AU  - Podlaha, Jiří - Schwanhaeuser Wulff, Kräuff Rainer
PY  - 2014
TI  - Experimental assessment of a new type of vascular prostheses with Adiponectin (Adipograft Ra 7/350 ) on sheep
JF  - Acta Veterinaria-Beograd
VL  - 64
IS  - 4
SP  - 426-437
EP  - 426-437
PB  - Faculty of Veterinary Medicine, University of Belgrade
SN  - 05678315
KW  - adiponectin
KW  - experimental surgery
KW  - preclinical trial
KW  - vascular prosthesis.
UR  - http://www.actaveterinaria.rs/volume/issue/14/81/706
N2  - Despite medical advancements, the development of an ideal vascular prosthesis still poses a great challenge. In this study the researchers tried to test and verify the characteristics of a new type of vascular prosthesis, using adiponectin (Adipograft Ra 1vk 7/350) developed at the Knitting Research Institute, a.s. Brno. Two types of vascular prostheses (12 with adiponectin and 6 as a control without adiponectin) were implanted in nine healthy 4-year-old Merino sheep. The implantation site was the common carotid artery and the length of the implant was 10 cm. We applied the theory of the protected coagulum, whereby all sheep received antibiotics as a prophylactic measure. A Doppler U.S. was performed before fi nishing each operation, in order to verify the patency of the prostheses. Each animal was followed up during the whole study and the prostheses were extirpated on days 30 and 100 (1 and 3 months). It was observed that all prostheses coated with adiponectin showed patency after extirpation. The lumen implants were of a consistent thickness of 7 mm. Histological study of the implanted prostheses confi rmed a quick, high quality, healing. Experimental vascular prostheses coated with adiponectin appeared to be successful in clinical practice. The researchers think that Adipograft Ra 1vk 7/350 can be a turning point in the development of vascular prostheses, due to its patency and quick healing.
ER  -

PODLAHA, Jiří and Kräuff Rainer SCHWANHAEUSER WULFF. Experimental assessment of a new type of vascular prostheses with Adiponectin (Adipograft Ra 7/350 ) on sheep. \textit{Acta Veterinaria-Beograd}. Beograd: Faculty of Veterinary Medicine, University of Belgrade, 2014, vol.~64, No~4, p.~426-437. ISSN~0567-8315. Available from: https://doi.org/10.2478/acve-2014-0040.

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