Mismatch negativity-like potential (MMN-like) in the
subthalamic nuclei in Parkinson’s disease patients

J 2014

Mismatch negativity-like potential (MMN-like) in the subthalamic nuclei in Parkinson’s disease patients

MINKS, Eduard, Pavel JURÁK, Jan CHLÁDEK, Jan CHRASTINA, Josef HALÁMEK et. al.

Základní údaje

Originální název

Mismatch negativity-like potential (MMN-like) in the subthalamic nuclei in Parkinson’s disease patients

Autoři

MINKS, Eduard (203 Česká republika, domácí), Pavel JURÁK (203 Česká republika), Jan CHLÁDEK (203 Česká republika, domácí), Jan CHRASTINA (203 Česká republika, domácí), Josef HALÁMEK (203 Česká republika), Daniel Joel SHAW (826 Velká Británie a Severní Irsko, domácí) a Martin BAREŠ (203 Česká republika, garant, domácí)

Vydání

Journal of Neural Transmission, Wien, Austria, Springer, 2014, 0300-9564

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Rakousko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.402

Kód RIV

RIV/00216224:14110/14:00074222

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s00702-014-1221-3

UT WoS

000345409000005

Klíčová slova anglicky

Intracranial electrodes; Mismatch negativity; MMN; MMN-like; STN; Subthalamic nucleus

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 29. 12. 2014 11:38, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

An infrequent change to an otherwise repetitive sequence of stimuli leads to the generation of mismatch negativity (MMN), even in the absence of attention. This evoked negative response occurs in the scalp-recorded electroencephalogram (EEG) over the temporal and frontal cortices, 100–250 ms after onset of the deviant stimulus. The MMN is used to detect sensory information processing. The aim of our study was to investigate whether MMN can be recorded in the subthalamic nuclei (STN) as evidence of auditory information processing on an unconscious level within this structure. To our knowledge, MMN has never been recorded in the human STN. We recorded intracerebral EEG using a MMN paradigm in five patients with Parkinson’s disease (PD) who were implanted with depth electrodes in the subthalamic nuclei (STN). We found far-field MMN when intracerebral contacts were connected to an extracranial reference electrode. In all five PD patients (and nine of ten intracerebral electrodes), we also found near-field MMN-like potentials when intracerebral contacts were referenced to one another, and in some electrodes, we observed phase reversals in these potentials. The mean time-to-peak latency of the intracerebral MMN-like potentials was 214 ± 38 ms (median 219 ms). We reveal MMN-like potentials in bilateral STN. This finding provides evidence that STN receives sensory (auditory) information from other structures. The question for further research is whether STN receives such signals through a previously described hyperdirect pathway between STN and frontal cortex (a known generator of the MMN potential) and if the STN contributes to sensorimotor integration.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

GAP103/11/0933, projekt VaV

Název: Analýza vysokofrekvenčního EEG signálu z hlubokých mozkových elektrod

Investor: Grantová agentura ČR, Analýza vysokofrekvenčního EEG signálu z hlubokých mozkových elektrod

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Přiložené soubory

EL_1213721.pdf

Požádat o autorskou verzi souboru

Citovat

MINKS, Eduard, Pavel JURÁK, Jan CHLÁDEK, Jan CHRASTINA, Josef HALÁMEK, Daniel Joel SHAW a Martin BAREŠ. Mismatch negativity-like potential (MMN-like) in the subthalamic nuclei in Parkinson’s disease patients. Journal of Neural Transmission. Wien, Austria: Springer, 2014, roč. 121, č. 12, s. 1507-1522. ISSN 0300-9564. Dostupné z: https://dx.doi.org/10.1007/s00702-014-1221-3.

@article{1213721,
   author = {Minks, Eduard and Jurák, Pavel and Chládek, Jan and Chrastina, Jan and Halámek, Josef and Shaw, Daniel Joel and Bareš, Martin},
   article_location = {Wien, Austria},
   article_number = {12},
   doi = {http://dx.doi.org/10.1007/s00702-014-1221-3},
   keywords = {Intracranial electrodes; Mismatch negativity; MMN; MMN-like; STN; Subthalamic nucleus},
   language = {eng},
   issn = {0300-9564},
   journal = {Journal of Neural Transmission},
   title = {Mismatch negativity-like potential (MMN-like) in the subthalamic nuclei in Parkinson’s disease patients},
   volume = {121},
   year = {2014}
}

TY  - JOUR
ID  - 1213721
AU  - Minks, Eduard - Jurák, Pavel - Chládek, Jan - Chrastina, Jan - Halámek, Josef - Shaw, Daniel Joel - Bareš, Martin
PY  - 2014
TI  - Mismatch negativity-like potential (MMN-like) in the subthalamic nuclei in Parkinson’s disease patients
JF  - Journal of Neural Transmission
VL  - 121
IS  - 12
SP  - 1507-1522
EP  - 1507-1522
PB  - Springer
SN  - 03009564
KW  - Intracranial electrodes
KW  - Mismatch negativity
KW  - MMN
KW  - MMN-like
KW  - STN
KW  - Subthalamic nucleus
N2  - An infrequent change to an otherwise repetitive sequence of stimuli leads to the generation of mismatch negativity (MMN), even in the absence of attention. This evoked negative response occurs in the scalp-recorded electroencephalogram (EEG) over the temporal and frontal cortices, 100–250 ms after onset of the deviant stimulus. The MMN is used to detect sensory information processing. The aim of our study was to investigate whether MMN can be recorded in the subthalamic nuclei (STN) as evidence of auditory information processing on an unconscious level within this structure. To our knowledge, MMN has never been recorded in the human STN. We recorded intracerebral EEG using a MMN paradigm in five patients with Parkinson’s disease (PD) who were implanted with depth electrodes in the subthalamic nuclei (STN). We found far-field MMN when intracerebral contacts were connected to an extracranial reference electrode. In all five PD patients (and nine of ten intracerebral electrodes), we also found near-field MMN-like potentials when intracerebral contacts were referenced to one another, and in some electrodes, we observed phase reversals in these potentials. The mean time-to-peak latency of the intracerebral MMN-like potentials was 214 ± 38 ms (median 219 ms). We reveal MMN-like potentials in bilateral STN. This finding provides evidence that STN receives sensory (auditory) information from other structures. The question for further research is whether STN receives such signals through a previously described hyperdirect pathway between STN and frontal cortex (a known generator of the MMN potential) and if the STN contributes to sensorimotor integration.
ER  -

MINKS, Eduard, Pavel JURÁK, Jan CHLÁDEK, Jan CHRASTINA, Josef HALÁMEK, Daniel Joel SHAW a Martin BAREŠ. Mismatch negativity-like potential (MMN-like) in the subthalamic nuclei in Parkinson’s disease patients. \textit{Journal of Neural Transmission}. Wien, Austria: Springer, 2014, roč.~121, č.~12, s.~1507-1522. ISSN~0300-9564. Dostupné z: https://dx.doi.org/10.1007/s00702-014-1221-3.

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