J 2014

Toxicity and survival outcomes of adjuvant chemoradiation for gastric and gastroesophageal junction cancer patients treated in period 2006-2009: an institutional experience

SLÁVIK, Marek, Petr BURKOŇ, Tomáš KAZDA, Marie BUDÍKOVÁ, M. SLAVIKOVA et. al.

Základní údaje

Originální název

Toxicity and survival outcomes of adjuvant chemoradiation for gastric and gastroesophageal junction cancer patients treated in period 2006-2009: an institutional experience

Autoři

SLÁVIK, Marek (703 Slovensko, domácí), Petr BURKOŇ (203 Česká republika, domácí), Tomáš KAZDA (203 Česká republika, domácí), Marie BUDÍKOVÁ (203 Česká republika, domácí), M. SLAVIKOVA (203 Česká republika), E. DVORAKOVA (203 Česká republika), Petr POSPÍŠIL (203 Česká republika, domácí), J. GOMBOSOVA (203 Česká republika), P. NAVRATILOVA (203 Česká republika) a Pavel ŠLAMPA (203 Česká republika, garant, domácí)

Vydání

Neoplasma, Bratislava, Slovenská akademie vied, 2014, 0028-2685

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.865

Kód RIV

RIV/00216224:14110/14:00077947

Organizační jednotka

Lékařská fakulta

UT WoS

000345950900013

Klíčová slova anglicky

adjuvant chemoradiation; gastric cancer; early toxicity; late toxicity; survival outcomes

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 3. 2. 2015 12:30, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Surgical resection is the mainstay of gastric or gastroesophageal junction cancer treatment and has curative potential for patients with early-stage disease. In order to improve the poor survival rates, there are two complementary treatment strategies used at most - perioperative chemotherapy based on UK Magic trial or adjuvant chemoradiation based on INT-0116 trial. Daily treatment decision making should be led also by institutional experiences with toxicity evaluation. We evaluated survival and toxicity outcomes of 47 consecutive patients who underwent adjuvant chemoradiation in our institution in the years 2006-2009. 45Gy in 5 weeks with concurrent two cycles of FUFA Mayo regimen chemotherapy were administrated as part of combined treatment. The acute toxicity was relatively mild (CTCAE scale): grade 2 nausea in 26%, vomiting in 13%, and diarrhoea grade 1 in 15% and general abdominal discomfort in 57% of patients. Grade 3 haematological and infectious complications in 6% and 2% respectively. Late adverse events were as follows: grade 1 esophageal toxicity in 17%, signs of mild chronic esophageal ulceration and esophageal stenosis in 9% of patients (50% of them had tracheoesophageal fistula). The Kaplan-Meier estimate of the median overall survival was 30.5 months with median 25.7 months disease free survival. The overall survival was statistically significantly affected by the amount of removed positive lymph nodes. For the proper evaluation of radiotherapy role in multimodal treatment approach, results of other clinical trials investigating role of concurrent radiotherapy in administration of perioperative chemotherapy will be necessary. Meanwhile, two equally approaches are possible, all having their pros and cons. Institutional toxicity evaluation is recommended in order to provide the best care possible.

Návaznosti

CZ.1.07/2.4.00/17.0100, interní kód MU
Název: A-Math-Net Síť pro transfer znalostí v aplikované matematice
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, A-Math-Net Síť pro transfer znalostí v aplikované matematice, 2.4 Partnerství a sítě