The modulatory role of subthalamic nucleus in cognitive
functions - A viewpoint.

J 2015

The modulatory role of subthalamic nucleus in cognitive functions - A viewpoint.

REKTOR, Ivan, Martina BOČKOVÁ, Jan CHRASTINA, Irena REKTOROVÁ, Marek BALÁŽ et. al.

Základní údaje

Originální název

The modulatory role of subthalamic nucleus in cognitive functions - A viewpoint.

Autoři

REKTOR, Ivan (203 Česká republika, garant, domácí), Martina BOČKOVÁ (203 Česká republika, domácí), Jan CHRASTINA (203 Česká republika, domácí), Irena REKTOROVÁ (203 Česká republika, domácí) a Marek BALÁŽ (703 Slovensko, domácí)

Vydání

Clinical Neurophysiology, Clare (Ireland), Elsevier Ireland Ltd. 2015, 1388-2457

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.426

Kód RIV

RIV/00216224:14740/15:00082209

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.clinph.2014.10.156

UT WoS

000351092100004

Klíčová slova anglicky

Cognitive functions; DBS; Electrophysiology; Non-motor functions; Subthalamic nucleus

Štítky

podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 2. 2016 16:05, Martina Prášilová

Anotace

V originále

The modifications of electrophysiological activities of subthalamic nucleus (STN) by non-motor tasks, i.e. movement observation, emotional stimuli and impulse control, were reported repeatedly. Despite being a small structure, STN is apparently involved in a variety of functions. Based on our own electrophysiological recordings and results of other groups we believe that it acts as an indirect modulator which may be involved in tuning the functional systems. STN may modulate specific cognitive activities via contextual modulation of certain cortical areas. Our findings support the hypothesis of a cortical-STN bypass (via hyperdirect pathway) of "classical" basal ganglia-thalamocortical circuitry, at least during the processing of certain cognitive functions. The modulation of cognitive functions appears to be selective, probably determined by the involvement of cortical neuronal populations interconnected with STN. There could also exist a spatial overlap of areas within STN regulating various functions. That may explain the fact that some non-motor symptoms of Parkinson's disease may improve after deep brain stimulation of STN. These improvements are likely caused by combination of direct stimulation effect on non-motor function and overall beneficial effect of motor improvement on quality of life.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Přiložené soubory

ZVV_2014_136_1215215_The_modulatory.pdf

Požádat o autorskou verzi souboru

Citovat

REKTOR, Ivan, Martina BOČKOVÁ, Jan CHRASTINA, Irena REKTOROVÁ a Marek BALÁŽ. The modulatory role of subthalamic nucleus in cognitive functions - A viewpoint. Clinical Neurophysiology. Clare (Ireland): Elsevier Ireland Ltd., 2015, roč. 126, č. 4, s. 653-658. ISSN 1388-2457. Dostupné z: https://dx.doi.org/10.1016/j.clinph.2014.10.156.

@article{1215215,
   author = {Rektor, Ivan and Bočková, Martina and Chrastina, Jan and Rektorová, Irena and Baláž, Marek},
   article_location = {Clare (Ireland)},
   article_number = {4},
   doi = {http://dx.doi.org/10.1016/j.clinph.2014.10.156},
   keywords = {Cognitive functions; DBS; Electrophysiology; Non-motor functions; Subthalamic nucleus},
   language = {eng},
   issn = {1388-2457},
   journal = {Clinical Neurophysiology},
   title = {The modulatory role of subthalamic nucleus in cognitive functions - A viewpoint.},
   url = {http://www.sciencedirect.com/science/article/pii/S1388245714007263#},
   volume = {126},
   year = {2015}
}

TY  - JOUR
ID  - 1215215
AU  - Rektor, Ivan - Bočková, Martina - Chrastina, Jan - Rektorová, Irena - Baláž, Marek
PY  - 2015
TI  - The modulatory role of subthalamic nucleus in cognitive functions - A viewpoint.
JF  - Clinical Neurophysiology
VL  - 126
IS  - 4
SP  - 653-658
EP  - 653-658
PB  - Elsevier Ireland Ltd.
SN  - 13882457
KW  - Cognitive functions
KW  - DBS
KW  - Electrophysiology
KW  - Non-motor functions
KW  - Subthalamic nucleus
UR  - http://www.sciencedirect.com/science/article/pii/S1388245714007263#
L2  - http://www.sciencedirect.com/science/article/pii/S1388245714007263#
N2  - The modifications of electrophysiological activities of subthalamic nucleus (STN) by non-motor tasks, i.e. movement observation, emotional stimuli and impulse control, were reported repeatedly. Despite being a small structure, STN is apparently involved in a variety of functions. Based on our own electrophysiological recordings and results of other groups we believe that it acts as an indirect modulator which may be involved in tuning the functional systems. STN may modulate specific cognitive activities via contextual modulation of certain cortical areas. Our findings support the hypothesis of a cortical-STN bypass (via hyperdirect pathway) of "classical" basal ganglia-thalamocortical circuitry, at least during the processing of certain cognitive functions. The modulation of cognitive functions appears to be selective, probably determined by the involvement of cortical neuronal populations interconnected with STN. There could also exist a spatial overlap of areas within STN regulating various functions. That may explain the fact that some non-motor symptoms of Parkinson's disease may improve after deep brain stimulation of STN. These improvements are likely caused by combination of direct stimulation effect on non-motor function and overall beneficial effect of motor improvement on quality of life.
ER  -

REKTOR, Ivan, Martina BOČKOVÁ, Jan CHRASTINA, Irena REKTOROVÁ a Marek BALÁŽ. The modulatory role of subthalamic nucleus in cognitive functions - A viewpoint. \textit{Clinical Neurophysiology}. Clare (Ireland): Elsevier Ireland Ltd., 2015, roč.~126, č.~4, s.~653-658. ISSN~1388-2457. Dostupné z: https://dx.doi.org/10.1016/j.clinph.2014.10.156.

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