| NOVÁČEK, Martin a Graeme SANDERS. The effect of clonidine on desflurane consumption using bispectral index monitoring during general anaesthesia: Randomised, double-blind, placebo controlled study. Anesteziologie & intenzivní medicína. Sokolská 31, 120 26, Praha 2: Česká lékařská společnost Jana Evangelisty Purkyně, 2014, roč. 6/25, s. 409-417, 8 s. ISSN 1214-2158. |
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@article{1215389,
author = {Nováček, Martin and Sanders, Graeme},
article_location = {Sokolská 31, 120 26, Praha 2},
keywords = {Clonidine, Desflurane, BIS, General anaesthesia},
language = {eng},
issn = {1214-2158},
journal = {Anesteziologie & intenzivní medicína},
title = {The effect of clonidine on desflurane consumption using bispectral index monitoring during general anaesthesia: Randomised, double-blind, placebo controlled study},
volume = {6/25},
year = {2014}
}
TY - JOUR
ID - 1215389
AU - Nováček, Martin - Sanders, Graeme
PY - 2014
TI - The effect of clonidine on desflurane consumption using bispectral index monitoring during general anaesthesia: Randomised, double-blind, placebo controlled study
JF - Anesteziologie & intenzivní medicína
VL - 6/25
SP - 409-417
EP - 409-417
PB - Česká lékařská společnost Jana Evangelisty Purkyně
SN - 12142158
KW - Clonidine, Desflurane, BIS, General anaesthesia
N2 - Objective This study was designed to test the hypothesis that clonidine deepens general anaesthesia as measured by the bispectral index (BIS) and allows the dose of desflurane to be reduced. Design Randomised, double-blind, placebo controlled study. Setting Department of Anaesthesia and Intensive Care of Regional and District General Hospital. Material and methods 50 patients undergoing general anaesthesia for elective total hip or total knee replacement were randomly allocated into two groups. One group had 2 µg kg-1 clonidine administered intravenously 10 minutes before general anaesthesia induction and the other was given an intravenous placebo. Depth of anaesthesia was guided by BIS with a target level between 40 and 60. The consumption of desflurane during anaesthesia was measured. After stopping desflurane administration at the end of surgery, time to return of consciousness (ROC) was recorded. Unpaired t-test was used for statistical analyses. Results 25 patients with clonidine and 25 with placebo were enrolled. The consumption of desflurane was significantly lower in the clonidine group 33.1 ± 5.0 g vs. the placebo group 44.5 ± 10.6 g (p<0.001). No difference was found in average time to ROC. This was 6.4 ± 3.8 min in the clonidine group vs. 6.2 ± 3.7 min in the placebo group (p=0.822). Conclusion Intravenous clonidine decreases the consumption of desflurane during general anaesthesia. This sparing effect is not associated with increased time to ROC.
ER -
NOVÁČEK, Martin a Graeme SANDERS. The effect of clonidine on desflurane consumption using bispectral index monitoring during general anaesthesia: Randomised, double-blind, placebo controlled study. \textit{Anesteziologie \&{} intenzivní medicína}. Sokolská 31, 120 26, Praha 2: Česká lékařská společnost Jana Evangelisty Purkyně, 2014, roč.~6/25, s.~409-417, 8 s. ISSN~1214-2158.
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