Default Mode Network Connectivity Patterns associated with
Visual Processing at Different Stages of Parkinson's Disease

J 2014

Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease

REKTOROVÁ, Irena, Lenka KRAJČOVIČOVÁ, Radek MAREČEK, Marie NOVÁKOVÁ, Michal MIKL et. al.

Základní údaje

Originální název

Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease

Autoři

REKTOROVÁ, Irena (203 Česká republika, garant, domácí), Lenka KRAJČOVIČOVÁ (703 Slovensko, domácí), Radek MAREČEK (203 Česká republika, domácí), Marie NOVÁKOVÁ (203 Česká republika, domácí) a Michal MIKL (203 Česká republika, domácí)

Vydání

JOURNAL OF ALZHEIMERS DISEASE, AMSTERDAM, IOS PRESS, 2014, 1387-2877

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.151

Kód RIV

RIV/00216224:14740/14:00074324

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.3233/JAD-132684

UT WoS

000341595800023

Klíčová slova anglicky

Default mode network; dementia; functional MRI; Parkinson's disease; precuneus; visual processing

Štítky

kontrola MP, MP, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 3. 2015 07:01, Martina Prášilová

Anotace

V originále

Background: The default mode network (DMN) decreases its activity when switching from a resting state to a cognitive task condition, while activity of the network engaged in the given task increases. Visual processing is typically disturbed in Parkinson's disease dementia (PDD). Objective: Using functional MRI, we studied the DMN effective connectivity patterns in PDD as compared with cognitively normal patients with Parkinson's disease (PD) and healthy controls (HC) when switching from baseline to a visual cognitive task condition. Methods: In all, 14 PDD, 18 PD, and 18 age-matched healthy controls participated in this functional MRI study. We used a psychophysiological interaction analysis with the precuneus (PCu) as a seed. The threshold was set at p(FWE) <0.05. Results: The healthy controls showed greater PCu connectivity with the bilateral middle temporal/middle occipital gyri at baseline than during the task condition. The correlation direction changed from positive to negative. Both PD and PDD showed disturbed DMN connectivity with the brain regions that are involved in bottom-up visual processing. In PD, we also found impaired integration of the areas engaged in the ventral attentional network, which might reflect specific attentional deficits observed during the early course of PD. In mild PDD, we detected increased engagement of areas involved in the dorsal attentional network, which corresponds to increased top-down control in this patient group as compared to the healthy controls. Conclusion: Our results show impaired dynamic interplay between large scale brain networks in PD that spread far beyond the motor system.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

GAP103/12/0552, projekt VaV

Název: Srovnání a inference metod hodnocení funkční a efektivní konektivity ve fMRI

Investor: Grantová agentura ČR, Srovnání a inference metod hodnocení funkční a efektivní konektivity ve fMRI

NT13499, projekt VaV

Název: Řeč, její poruchy a kognitivní funkce u Parkinsonovy nemoci

Citovat

REKTOROVÁ, Irena, Lenka KRAJČOVIČOVÁ, Radek MAREČEK, Marie NOVÁKOVÁ a Michal MIKL. Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease. JOURNAL OF ALZHEIMERS DISEASE. AMSTERDAM: IOS PRESS, 2014, roč. 42, č. 3, s. "S217"-"S228", 12 s. ISSN 1387-2877. Dostupné z: https://dx.doi.org/10.3233/JAD-132684.

@article{1216644,
   author = {Rektorová, Irena and Krajčovičová, Lenka and Mareček, Radek and Nováková, Marie and Mikl, Michal},
   article_location = {AMSTERDAM},
   article_number = {3},
   doi = {http://dx.doi.org/10.3233/JAD-132684},
   keywords = {Default mode network; dementia; functional MRI; Parkinson's disease; precuneus; visual processing},
   language = {eng},
   issn = {1387-2877},
   journal = {JOURNAL OF ALZHEIMERS DISEASE},
   title = {Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease},
   url = {https://iospress.metapress.com/content/e64v6362j4467140/resource-secured/?target=fulltext.pdf},
   volume = {42},
   year = {2014}
}

TY  - JOUR
ID  - 1216644
AU  - Rektorová, Irena - Krajčovičová, Lenka - Mareček, Radek - Nováková, Marie - Mikl, Michal
PY  - 2014
TI  - Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease
JF  - JOURNAL OF ALZHEIMERS DISEASE
VL  - 42
IS  - 3
SP  - "S217"-"S228"
EP  - "S217"-"S228"
PB  - IOS PRESS
SN  - 13872877
KW  - Default mode network
KW  - dementia
KW  - functional MRI
KW  - Parkinson's disease
KW  - precuneus
KW  - visual processing
UR  - https://iospress.metapress.com/content/e64v6362j4467140/resource-secured/?target=fulltext.pdf
L2  - https://iospress.metapress.com/content/e64v6362j4467140/resource-secured/?target=fulltext.pdf
N2  - Background: The default mode network (DMN) decreases its activity when switching from a resting state to a cognitive task condition, while activity of the network engaged in the given task increases. Visual processing is typically disturbed in Parkinson's disease dementia (PDD). Objective: Using functional MRI, we studied the DMN effective connectivity patterns in PDD as compared with cognitively normal patients with Parkinson's disease (PD) and healthy controls (HC) when switching from baseline to a visual cognitive task condition. Methods: In all, 14 PDD, 18 PD, and 18 age-matched healthy controls participated in this functional MRI study. We used a psychophysiological interaction analysis with the precuneus (PCu) as a seed. The threshold was set at p(FWE) <0.05. Results: The healthy controls showed greater PCu connectivity with the bilateral middle temporal/middle occipital gyri at baseline than during the task condition. The correlation direction changed from positive to negative. Both PD and PDD showed disturbed DMN connectivity with the brain regions that are involved in bottom-up visual processing. In PD, we also found impaired integration of the areas engaged in the ventral attentional network, which might reflect specific attentional deficits observed during the early course of PD. In mild PDD, we detected increased engagement of areas involved in the dorsal attentional network, which corresponds to increased top-down control in this patient group as compared to the healthy controls. Conclusion: Our results show impaired dynamic interplay between large scale brain networks in PD that spread far beyond the motor system.
ER  -

REKTOROVÁ, Irena, Lenka KRAJČOVIČOVÁ, Radek MAREČEK, Marie NOVÁKOVÁ a Michal MIKL. Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease. \textit{JOURNAL OF ALZHEIMERS DISEASE}. AMSTERDAM: IOS PRESS, 2014, roč.~42, č.~3, s.~''S217''-''S228'', 12 s. ISSN~1387-2877. Dostupné z: https://dx.doi.org/10.3233/JAD-132684.

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