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@article{1216652,
author = {Krajčovičová, Lenka and Mikl, Michal and Mareček, Radek and Rektorová, Irena},
article_location = {AMSTERDAM},
article_number = {4},
doi = {http://dx.doi.org/10.3233/JAD-131208},
keywords = {Alzheimer's disease; default mode network; functional MRI; posterior cingulate; visual processing},
language = {eng},
issn = {1387-2877},
journal = {JOURNAL OF ALZHEIMERS DISEASE},
title = {Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing},
url = {https://iospress.metapress.com/content/y7477621420j4145/resource-secured/?target=fulltext.pdf},
volume = {41},
year = {2014}
}
TY - JOUR
ID - 1216652
AU - Krajčovičová, Lenka - Mikl, Michal - Mareček, Radek - Rektorová, Irena
PY - 2014
TI - Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing
JF - JOURNAL OF ALZHEIMERS DISEASE
VL - 41
IS - 4
SP - 1229-1238
EP - 1229-1238
PB - IOS PRESS
SN - 13872877
KW - Alzheimer's disease
KW - default mode network
KW - functional MRI
KW - posterior cingulate
KW - visual processing
UR - https://iospress.metapress.com/content/y7477621420j4145/resource-secured/?target=fulltext.pdf
L2 - https://iospress.metapress.com/content/y7477621420j4145/resource-secured/?target=fulltext.pdf
N2 - Changes in connectivity of the posterior node of the default mode network (DMN) were studied when switching from baseline to a cognitive task using functional magnetic resonance imaging. In all, 15 patients with mild to moderate Alzheimer's disease (AD) and 18 age-, gender-, and education-matched healthy controls (HC) participated in the study. Psychophysiological interactions analysis was used to assess the specific alterations in the DMN connectivity (deactivation-based) due to psychological effects from the complex visual scene encoding task. In HC, we observed task-induced connectivity decreases between the posterior cingulate and middle temporal and occipital visual cortices. These findings imply successful involvement of the ventral visual pathway during the visual processing in our HC cohort. In AD, involvement of the areas engaged in the ventral visual pathway was observed only in a small volume of the right middle temporal gyrus. Additional connectivity changes (decreases) in AD were present between the posterior cingulate and superior temporal gyrus when switching from baseline to task condition. These changes are probably related to both disturbed visual processing and the DMN connectivity in AD and reflect deficits and compensatory mechanisms within the large scale brain networks in this patient population. Studying the DMN connectivity using psychophysiological interactions analysis may provide a sensitive tool for exploring early changes in AD and their dynamics during the disease progression.
ER -
KRAJČOVIČOVÁ, Lenka, Michal MIKL, Radek MAREČEK a Irena REKTOROVÁ. Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing. \textit{JOURNAL OF ALZHEIMERS DISEASE}. AMSTERDAM: IOS PRESS, 2014, roč.~41, č.~4, s.~1229-1238. ISSN~1387-2877. Dostupné z: https://dx.doi.org/10.3233/JAD-131208.
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