Investigation of summation mechanisms in the pupillomotor
system

J 2014

Investigation of summation mechanisms in the pupillomotor system

SKORKOVSKÁ, Karolína; Helmut WILHELM; Holger LÜDTKE; Barbara WILHELM; Anne KURTENBACH et. al.

Basic information

Original name

Investigation of summation mechanisms in the pupillomotor system

Authors

SKORKOVSKÁ, Karolína (203 Czech Republic, guarantor, belonging to the institution); Helmut WILHELM (276 Germany); Holger LÜDTKE (276 Germany); Barbara WILHELM (276 Germany) and Anne KURTENBACH (276 Germany)

Edition

Graefes Archive for Clinical and Experimental Ophthalmology, New York, Springer, 2014, 0721-832X

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

is not subject to a state or trade secret

Impact factor

Impact factor: 1.908

RIV identification code

RIV/00216224:14110/14:00078357

Organization unit

Faculty of Medicine

DOI

https://doi.org/10.1007/s00417-014-2677-4

UT WoS

000338492500017

EID Scopus

2-s2.0-84904319391

Keywords in English

Pupil; Receptive field; Pupil perimetry; Campimetry

Abstract

In the original language

To ascertain whether the pupillary response amplitude shows spatial summation of responses with increasing size of retinal stimulation, and to examine the pupillary responses for evidence of surround inhibition, analogous to that found in the receptive fields of the retinal ganglion cells. By means of infrared-video-pupillography, the pupil reaction to stimuli of increasing size (1-15A degrees) was measured in 30 normal subjects. Four different retinal locations (0A degrees, 20A degrees and 40A degrees eccentricity on the upper temporal retina and 20A degrees eccentricity on the lower nasal retina) were examined at four different stimulus luminances (17, 47, 87 and 140 cd/m(2)). When the average log amplitude of the pupil light reaction from the 30 subjects is plotted as a function of the log area of the stimulus, a bi-linear response is observed, which is most pronounced for the two higher luminances. The intersection points of the two linear responses are 2.01A degrees in the fovea, 2.80A degrees at 20A degrees upper temporal retina, 2.85A degrees at 20A degrees lower nasal retina and 4.86A degrees at 40A degrees upper temporal retina. This study suggests that pupillomotor summation areas consist of both summation and inhibitory zones. They show larger diameters than receptive fields of retinal ganglion cells and do not appear to reflect pupillary summation areas of the pretectal olivary nucleus luminance neurons.

Cite

SKORKOVSKÁ, Karolína; Helmut WILHELM; Holger LÜDTKE; Barbara WILHELM and Anne KURTENBACH. Investigation of summation mechanisms in the pupillomotor system. Graefes Archive for Clinical and Experimental Ophthalmology. New York: Springer, 2014, vol. 252, No 7, p. 1155-1160. ISSN 0721-832X. Available from: https://doi.org/10.1007/s00417-014-2677-4.

@article{1216654,
   author = {Skorkovská, Karolína and Wilhelm, Helmut and Lüdtke, Holger and Wilhelm, Barbara and Kurtenbach, Anne},
   article_location = {New York},
   article_number = {7},
   doi = {https://doi.org/10.1007/s00417-014-2677-4},
   keywords = {Pupil; Receptive field; Pupil perimetry; Campimetry},
   language = {eng},
   issn = {0721-832X},
   journal = {Graefes Archive for Clinical and Experimental Ophthalmology},
   title = {Investigation of summation mechanisms in the pupillomotor system},
   volume = {252},
   year = {2014}
}

TY  - JOUR
ID  - 1216654
AU  - Skorkovská, Karolína - Wilhelm, Helmut - Lüdtke, Holger - Wilhelm, Barbara - Kurtenbach, Anne
PY  - 2014
TI  - Investigation of summation mechanisms in the pupillomotor system
JF  - Graefes Archive for Clinical and Experimental Ophthalmology
VL  - 252
IS  - 7
SP  - 1155-1160
EP  - 1155-1160
PB  - Springer
SN  - 0721832X
KW  - Pupil
KW  - Receptive field
KW  - Pupil perimetry
KW  - Campimetry
N2  - To ascertain whether the pupillary response amplitude shows spatial summation of responses with increasing size of retinal stimulation, and to examine the pupillary responses for evidence of surround inhibition, analogous to that found in the receptive fields of the retinal ganglion cells. By means of infrared-video-pupillography, the pupil reaction to stimuli of increasing size (1-15A degrees) was measured in 30 normal subjects. Four different retinal locations (0A degrees, 20A degrees and 40A degrees eccentricity on the upper temporal retina and 20A degrees eccentricity on the lower nasal retina) were examined at four different stimulus luminances (17, 47, 87 and 140 cd/m(2)). When the average log amplitude of the pupil light reaction from the 30 subjects is plotted as a function of the log area of the stimulus, a bi-linear response is observed, which is most pronounced for the two higher luminances. The intersection points of the two linear responses are 2.01A degrees in the fovea, 2.80A degrees at 20A degrees upper temporal retina, 2.85A degrees at 20A degrees lower nasal retina and 4.86A degrees at 40A degrees upper temporal retina. This study suggests that pupillomotor summation areas consist of both summation and inhibitory zones. They show larger diameters than receptive fields of retinal ganglion cells and do not appear to reflect pupillary summation areas of the pretectal olivary nucleus luminance neurons.
ER  -

SKORKOVSKÁ, Karolína; Helmut WILHELM; Holger LÜDTKE; Barbara WILHELM and Anne KURTENBACH. Investigation of summation mechanisms in the pupillomotor system. \textit{Graefes Archive for Clinical and Experimental Ophthalmology}. New York: Springer, 2014, vol.~252, No~7, p.~1155-1160. ISSN~0721-832X. Available from: https://doi.org/10.1007/s00417-014-2677-4.

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