Grey Matter Changes in Cognitively Impaired Parkinson's Disease
Patients

J 2014

Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients

REKTOROVÁ, Irena, Roberta BIUNDO, Radek MAREČEK, Luca WEIS, Dag AARSLAND et. al.

Základní údaje

Originální název

Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients

Autoři

REKTOROVÁ, Irena (203 Česká republika, garant, domácí), Roberta BIUNDO (380 Itálie), Radek MAREČEK (203 Česká republika, domácí), Luca WEIS (380 Itálie), Dag AARSLAND (752 Švédsko) a Angelo ANTONINI (380 Itálie)

Vydání

Plos one, SAN FRANCISCO, PUBLIC LIBRARY SCIENCE, 2014, 1932-6203

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.234

Kód RIV

RIV/00216224:14740/14:00078359

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1371/journal.pone.0085595

UT WoS

000330244500080

Klíčová slova anglicky

FRONTAL ASSESSMENT BATTERY; ITALIAN POPULATION-SAMPLE; SOURCE-BASED MORPHOMETRY; DEFAULT MODE NETWORK; DIAGNOSTIC-CRITERIA; ALZHEIMERS-DISEASE; NORMATIVE VALUES; CEREBRAL ATROPHY; LEWY BODIES; DEMENTIA

Štítky

kontrola MP, MP, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 3. 2015 07:12, Martina Prášilová

Anotace

V originále

Background: Cortical changes associated with cognitive decline in Parkinson's disease (PD) are not fully explored and require investigations with established diagnostic classification criteria. Objective: We used MRI source-based morphometry to evaluate specific differences in grey matter volume patterns across 4 groups of subjects: healthy controls (HC), PD with normal cognition (PD-NC), PD with mild cognitive impairment (MCI-PD) and PD with dementia (PDD). Methods: We examined 151 consecutive subjects: 25 HC, 75 PD-NC, 29 MCI-PD, and 22 PDD at an Italian and Czech movement disorder centre. Operational diagnostic criteria were applied to classify MCI-PD and PDD. All structural MRI images were processed together in the Czech centre. The spatial independent component analysis was used to assess group differences of local grey matter volume. Results: We identified two independent patterns of grey matter volume deviations: a) Reductions in the hippocampus and temporal lobes; b) Decreases in fronto-parietal regions and increases in the midbrain/cerebellum. Both patterns differentiated PDD from all other groups and correlated with visuospatial deficits and letter verbal fluency, respectively. Only the second pattern additionally differentiated PD-NC from HC. Conclusion: Grey matter changes in PDD involve areas associated with Alzheimer-like pathology while fronto-parietal abnormalities are possibly an early marker of PD cognitive decline. These findings are consistent with a non-linear cognitive progression in PD.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

REKTOROVÁ, Irena, Roberta BIUNDO, Radek MAREČEK, Luca WEIS, Dag AARSLAND a Angelo ANTONINI. Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients. Plos one. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2014, roč. 9, č. 1, s. "nestránkované", 8 s. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0085595.

@article{1216656,
   author = {Rektorová, Irena and Biundo, Roberta and Mareček, Radek and Weis, Luca and Aarsland, Dag and Antonini, Angelo},
   article_location = {SAN FRANCISCO},
   article_number = {1},
   doi = {http://dx.doi.org/10.1371/journal.pone.0085595},
   keywords = {FRONTAL ASSESSMENT BATTERY; ITALIAN POPULATION-SAMPLE; SOURCE-BASED MORPHOMETRY; DEFAULT MODE NETWORK; DIAGNOSTIC-CRITERIA; ALZHEIMERS-DISEASE; NORMATIVE VALUES; CEREBRAL ATROPHY; LEWY BODIES; DEMENTIA},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients},
   url = {http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0085595&representation=PDF},
   volume = {9},
   year = {2014}
}

TY  - JOUR
ID  - 1216656
AU  - Rektorová, Irena - Biundo, Roberta - Mareček, Radek - Weis, Luca - Aarsland, Dag - Antonini, Angelo
PY  - 2014
TI  - Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients
JF  - Plos one
VL  - 9
IS  - 1
SP  - "nestránkované"
EP  - "nestránkované"
PB  - PUBLIC LIBRARY SCIENCE
SN  - 19326203
KW  - FRONTAL ASSESSMENT BATTERY
KW  - ITALIAN POPULATION-SAMPLE
KW  - SOURCE-BASED MORPHOMETRY
KW  - DEFAULT MODE NETWORK
KW  - DIAGNOSTIC-CRITERIA
KW  - ALZHEIMERS-DISEASE
KW  - NORMATIVE VALUES
KW  - CEREBRAL ATROPHY
KW  - LEWY BODIES
KW  - DEMENTIA
UR  - http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0085595&representation=PDF
L2  - http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0085595&representation=PDF
N2  - Background: Cortical changes associated with cognitive decline in Parkinson's disease (PD) are not fully explored and require investigations with established diagnostic classification criteria. Objective: We used MRI source-based morphometry to evaluate specific differences in grey matter volume patterns across 4 groups of subjects: healthy controls (HC), PD with normal cognition (PD-NC), PD with mild cognitive impairment (MCI-PD) and PD with dementia (PDD). Methods: We examined 151 consecutive subjects: 25 HC, 75 PD-NC, 29 MCI-PD, and 22 PDD at an Italian and Czech movement disorder centre. Operational diagnostic criteria were applied to classify MCI-PD and PDD. All structural MRI images were processed together in the Czech centre. The spatial independent component analysis was used to assess group differences of local grey matter volume. Results: We identified two independent patterns of grey matter volume deviations: a) Reductions in the hippocampus and temporal lobes; b) Decreases in fronto-parietal regions and increases in the midbrain/cerebellum. Both patterns differentiated PDD from all other groups and correlated with visuospatial deficits and letter verbal fluency, respectively. Only the second pattern additionally differentiated PD-NC from HC. Conclusion: Grey matter changes in PDD involve areas associated with Alzheimer-like pathology while fronto-parietal abnormalities are possibly an early marker of PD cognitive decline. These findings are consistent with a non-linear cognitive progression in PD.
ER  -

REKTOROVÁ, Irena, Roberta BIUNDO, Radek MAREČEK, Luca WEIS, Dag AARSLAND a Angelo ANTONINI. Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients. \textit{Plos one}. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2014, roč.~9, č.~1, s.~''nestránkované'', 8 s. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0085595.

Podrobný výpis o publikaci