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@article{1218001,
author = {Švandová, Eva and Veselá, Barbora and Šmarda, Jan and Hampl, Aleš and Radlanski, R. J. and Matalova, E.},
article_location = {Hoboken},
article_number = {5},
doi = {http://dx.doi.org/10.1111/ahe.12145},
keywords = {C-MYB; B-MYB; SELF-RENEWAL; A-MYB; DIFFERENTIATION; EXPRESSION; TOOTH; PROLIFERATION; LOCALIZATION; PROGENITORS},
language = {eng},
issn = {0340-2096},
journal = {Anatomia Histologia Embryologia},
title = {Mouse Incisor Stem Cell Niche and Myb Transcription Factors},
volume = {44},
year = {2015}
}
TY - JOUR
ID - 1218001
AU - Švandová, Eva - Veselá, Barbora - Šmarda, Jan - Hampl, Aleš - Radlanski, R. J. - Matalova, E.
PY - 2015
TI - Mouse Incisor Stem Cell Niche and Myb Transcription Factors
JF - Anatomia Histologia Embryologia
VL - 44
IS - 5
SP - 338-344
EP - 338-344
PB - Wiley-Blackwell
SN - 03402096
KW - C-MYB
KW - B-MYB
KW - SELF-RENEWAL
KW - A-MYB
KW - DIFFERENTIATION
KW - EXPRESSION
KW - TOOTH
KW - PROLIFERATION
KW - LOCALIZATION
KW - PROGENITORS
N2 - Dental hard tissues are formed particularly by odontoblasts (dentin) and ameloblasts (enamel). Whereas the reparation of dentin is often observed, enamel does not regenerate in most species. However, in mouse incisor, a population of somatic stem cells in the cervical loop is responsible for the incisor regeneration. Understanding of the specificities of these cells is therefore of an interest in basic research as well as regenerative therapies. The Myb transcription factors are involved in essential cellular processes. B-Myb is often linked to the stem cell phenotype, and c-Myb expression marks undifferentiated and proliferating cells such as the stem cells. In the presented study, temporo-spatial expression of B-Myb and c-Myb proteins was correlated with localisation of putative somatic stem cells in the mouse incisor cervical loop by immunohistochemistry. B-Myb expression was localised mostly in the zone of transitamplifying cells, and c-Myb was found in the inner enamel epithelium, the surrounding mesenchyme and in differentiated cells. Taken together, neither B-Myb nor c-Myb was exclusively present or abundant in the area of the incisor stem cell niche. Their distribution, however, supports recently reported novel functions of c-Myb in differentiation of hard tissue cells.
ER -
ŠVANDOVÁ, Eva, Barbora VESELÁ, Jan ŠMARDA, Aleš HAMPL, R. J. RADLANSKI a E. MATALOVA. Mouse Incisor Stem Cell Niche and Myb Transcription Factors. \textit{Anatomia Histologia Embryologia}. Hoboken: Wiley-Blackwell, 2015, roč.~44, č.~5, s.~338-344. ISSN~0340-2096. Dostupné z: https://dx.doi.org/10.1111/ahe.12145.
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