| DUBOVÝ, Petr, Ilona KLUSÁKOVÁ a Ivana HRADILOVÁ SVÍŽENSKÁ. Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury. BioMed Research International. USA: Hindawi Publishing Corporation, 2014, roč. 2014, April, s. "nestránkováno", 7 s. ISSN 2314-6133. Dostupné z: https://dx.doi.org/10.1155/2014/691041. |
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@article{1220228,
author = {Dubový, Petr and Klusáková, Ilona and Hradilová Svíženská, Ivana},
article_location = {USA},
article_number = {April},
doi = {http://dx.doi.org/10.1155/2014/691041},
keywords = {activated Schwann cell; growing axons; reinnervation; inflammatory mediators},
language = {eng},
issn = {2314-6133},
journal = {BioMed Research International},
title = {Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury},
url = {http://www.hindawi.com/journals/bmri/2014/691041/},
volume = {2014},
year = {2014}
}
TY - JOUR
ID - 1220228
AU - Dubový, Petr - Klusáková, Ilona - Hradilová Svíženská, Ivana
PY - 2014
TI - Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury
JF - BioMed Research International
VL - 2014
IS - April
SP - "nestránkováno"
EP - "nestránkováno"
PB - Hindawi Publishing Corporation
SN - 23146133
KW - activated Schwann cell
KW - growing axons
KW - reinnervation
KW - inflammatory mediators
UR - http://www.hindawi.com/journals/bmri/2014/691041/
L2 - http://www.hindawi.com/journals/bmri/2014/691041/
N2 - Activated Schwann cells distal to nerve injury upregulate inflammatory mediators, including cytokines. The goal of the present study was to investigate expression of proinflammatory (IL-1b, TNFa) and anti-inflammatory cytokines (IL-4, IL-10) in activated Schwann cells in relation to growing axons distal to crush injury of rat sciatic nerves. Seven days fromsciatic nerve crush, transverse cryostat sections were cut 5 mm distal to lesion and incubated for double immunostaining to indicate Schwann cells (GFAP or S100b) and individual investigated cytokines or to demonstrate growing axons (GAP43). The Schwann cells of naive sciatic nerves and those removed from sham-operated rats displayed similar weak immunoreactivity for the investigated cytokines. In contrast, increased intensity of cytokine immunofluorescence was found in Schwann cells distal to crush lesion. The cytokinepositive Schwann cells were found in close contact with growing axons detected by immunostaining for GAP43. The results of immunohistochemical analysis distal to nerve crush injury suggest that inflammatory profiling of Schwann cells including upregulation of both pro- and anti-inflammatory cytokines does not prevent growth of axons distal to nerve crush injury.
ER -
DUBOVÝ, Petr, Ilona KLUSÁKOVÁ a Ivana HRADILOVÁ SVÍŽENSKÁ. Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury. \textit{BioMed Research International}. USA: Hindawi Publishing Corporation, 2014, roč.~2014, April, s.~''nestránkováno'', 7 s. ISSN~2314-6133. Dostupné z: https://dx.doi.org/10.1155/2014/691041.
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