Successful use of metronomic vinblastine and fluorothymidine
pet imaging for the management of intramedullary spinal cord
anaplastic oligoastrocytoma in a child

J 2014

Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child

DEMLOVÁ, Regina, Kristýna MELICHÁRKOVÁ, Zdeněk ŘEHÁK, Leoš KŘEN, Hana OŠLEJŠKOVÁ et. al.

Základní údaje

Originální název

Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child

Autoři

DEMLOVÁ, Regina (203 Česká republika, garant, domácí), Kristýna MELICHÁRKOVÁ (203 Česká republika, domácí), Zdeněk ŘEHÁK (203 Česká republika, domácí), Leoš KŘEN (203 Česká republika, domácí), Hana OŠLEJŠKOVÁ (203 Česká republika, domácí) a Jaroslav ŠTĚRBA (203 Česká republika, domácí)

Vydání

Current Oncology, Toronto, Multimed INC. 2014, 1198-0052

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Kanada

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.785

Kód RIV

RIV/00216224:14110/14:00078991

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3747/co.21.2147

UT WoS

000348599900008

Klíčová slova anglicky

Biomarkers; Metronomic chemotherapy; Pediatric glioma; PET imaging; Vinblastine

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 3. 2015 11:39, Soňa Böhmová

Anotace

V originále

Background: Children with high-grade glioma still have a poor prognosis despite the use of multimodal therapy including surgery, radiotherapy, and chemotherapy. New therapeutic strategies and methods evaluating such therapies are needed. Observation: Here we describe a child with anaplastic oligodendroglioma of the spinal cord who was unable to tolerate standard chemoradiotherapy and who had still-vital residual tumour during therapy. A good response was obtained with low-dose metronomic treatment containing vinblastine. The treatment was guided according to gradual response assessed using various positron-emission tomography tracers. Conclusions: Metronomic treatment guided by positron-emission tomography could be a reasonable option in some high-risk pediatric tumours.

Návaznosti

LM2011017, projekt VaV

Název: Advanced Cell Immunotherapy Unit - ACIU

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Advanced cell immunotherapy unit BVI-ACIU

Citovat

DEMLOVÁ, Regina, Kristýna MELICHÁRKOVÁ, Zdeněk ŘEHÁK, Leoš KŘEN, Hana OŠLEJŠKOVÁ a Jaroslav ŠTĚRBA. Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child. Current Oncology. Toronto: Multimed INC., 2014, roč. 21, č. 6, s. "E790"-"E793", 4 s. ISSN 1198-0052. Dostupné z: https://dx.doi.org/10.3747/co.21.2147.

@article{1220489,
   author = {Demlová, Regina and Melichárková, Kristýna and Řehák, Zdeněk and Křen, Leoš and Ošlejšková, Hana and Štěrba, Jaroslav},
   article_location = {Toronto},
   article_number = {6},
   doi = {http://dx.doi.org/10.3747/co.21.2147},
   keywords = {Biomarkers; Metronomic chemotherapy; Pediatric glioma; PET imaging; Vinblastine},
   language = {eng},
   issn = {1198-0052},
   journal = {Current Oncology},
   title = {Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child},
   volume = {21},
   year = {2014}
}

TY  - JOUR
ID  - 1220489
AU  - Demlová, Regina - Melichárková, Kristýna - Řehák, Zdeněk - Křen, Leoš - Ošlejšková, Hana - Štěrba, Jaroslav
PY  - 2014
TI  - Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child
JF  - Current Oncology
VL  - 21
IS  - 6
SP  - "E790"-"E793"
EP  - "E790"-"E793"
PB  - Multimed INC.
SN  - 11980052
KW  - Biomarkers
KW  - Metronomic chemotherapy
KW  - Pediatric glioma
KW  - PET imaging
KW  - Vinblastine
N2  - Background: Children with high-grade glioma still have a poor prognosis despite the use of multimodal therapy including surgery, radiotherapy, and chemotherapy. New therapeutic strategies and methods evaluating such therapies are needed. Observation: Here we describe a child with anaplastic oligodendroglioma of the spinal cord who was unable to tolerate standard chemoradiotherapy and who had still-vital residual tumour during therapy. A good response was obtained with low-dose metronomic treatment containing vinblastine. The treatment was guided according to gradual response assessed using various positron-emission tomography tracers. Conclusions: Metronomic treatment guided by positron-emission tomography could be a reasonable option in some high-risk pediatric tumours.
ER  -

DEMLOVÁ, Regina, Kristýna MELICHÁRKOVÁ, Zdeněk ŘEHÁK, Leoš KŘEN, Hana OŠLEJŠKOVÁ a Jaroslav ŠTĚRBA. Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child. \textit{Current Oncology}. Toronto: Multimed INC., 2014, roč.~21, č.~6, s.~''E790''-''E793'', 4 s. ISSN~1198-0052. Dostupné z: https://dx.doi.org/10.3747/co.21.2147.

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