ZIMMERMANN, Michal and T. DE LANGE. 53BP1: pro choice in DNA repair. TRENDS IN CELL BIOLOGY. LONDON: ELSEVIER SCIENCE LONDON, 2014, vol. 24, No 2, p. 108-117. ISSN 0962-8924. Available from: https://dx.doi.org/10.1016/j.tcb.2013.09.003.
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Basic information
Original name 53BP1: pro choice in DNA repair
Authors ZIMMERMANN, Michal (203 Czech Republic, guarantor, belonging to the institution) and T. DE LANGE (840 United States of America).
Edition TRENDS IN CELL BIOLOGY, LONDON, ELSEVIER SCIENCE LONDON, 2014, 0962-8924.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 12.007
RIV identification code RIV/00216224:14740/14:00074404
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1016/j.tcb.2013.09.003
UT WoS 000332498100003
Keywords in English 53BP1; Rif1; PTIP; NHEJ; HDR; PARPi; telomere; CSR; V(D)J; BRCA1; resection
Tags kontrola MP, MP, rivok
Tags International impact, Reviewed
Changed by Changed by: Martina Prášilová, učo 342282. Changed: 23/2/2015 10:01.
Abstract
The DNA damage response factor 53BP1 functions at the intersection of two major double strand break (DSB) repair pathways - promoting nonhomologous end-joining (NHEJ) and inhibiting homology-directed repair (HDR) - and integrates cellular inputs to ensure their timely execution in the proper cellular contexts. Recent work has revealed that 53BP1 controls 5' end resection at DNA ends, mediates synapsis of DNA ends, promotes the mobility of damaged chromatin, improves DSB repair in heterochromatic regions, and contributes to lethal mis-repair of DSBs in BRCA1-deficient cells. Here we review these aspects of 53BP1 and discuss new data revealing how 53BP1 is loaded onto chromatin and uses its interacting factors Rif1 and PTIP to promote NHEJ and inhibit HDR.
Links
GAP205/12/0550, research and development projectName: Dynamika vzniku shelterinového komplexu
Investor: Czech Science Foundation
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