DEVELOPING ROLE OF ADVANCED MRI TECHNIQUES FOR DIAGNOSIS OF
HIGH-GRADE GLIOMA RELAPSE AFTER COMPLEX ONCOLOGY TREATMENT

a 2014

DEVELOPING ROLE OF ADVANCED MRI TECHNIQUES FOR DIAGNOSIS OF HIGH-GRADE GLIOMA RELAPSE AFTER COMPLEX ONCOLOGY TREATMENT

JANČÁLEK, Radim, Martin BULIK, Tomáš KAZDA, Petr POSPÍŠIL, Pavel ŠLAMPA et. al.

Základní údaje

Originální název

DEVELOPING ROLE OF ADVANCED MRI TECHNIQUES FOR DIAGNOSIS OF HIGH-GRADE GLIOMA RELAPSE AFTER COMPLEX ONCOLOGY TREATMENT

Autoři

JANČÁLEK, Radim (203 Česká republika, domácí), Martin BULIK (203 Česká republika, domácí), Tomáš KAZDA (203 Česká republika, garant, domácí), Petr POSPÍŠIL (203 Česká republika, domácí), Pavel ŠLAMPA (203 Česká republika, domácí) a Martin SMRČKA (203 Česká republika, domácí)

Vydání

11th Congress of the European Association of Neuro-Oncology, 2014

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 6.776

Kód RIV

RIV/00216224:14110/14:00079191

Organizační jednotka

Lékařská fakulta

ISSN

DOI

http://dx.doi.org/10.1093/neuonc/nou174.311

UT WoS

000344235700312

Klíčová slova anglicky

High-grade gliomas; brain tumors; MRI

Štítky

EL OK

Změněno: 23. 2. 2015 16:26, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

PURPOSE/OBJECTIVES: High-grade gliomas (HGG) are the most common primary brain tumors of adults. Despite a multidisciplinary approach, HGGs frequently recur as a new gadolinium-enhanced MRI lesion at or near the site of the original tumor; thus, at the site of high-dose target volume for radiotherapy. An early differentiation between HGG relapse and changes in connection with oncology treatment (pseudoprogression or radionecrosis) is still problematic by commonly used diagnostic imaging techniques. The goal of our project is to verify whether a combination of diffusion-weighted MR imaging (DWI) and proton magnetic resonance spectroscopy (MRS) increase specificity of the conventional structural MRI with gadolinium for early non-invasive differentiation between of HGG relapse and pseudoprogression or radionecrosis. MATERIALS/METHODS: Patients (n= 26) with HGG and structural progression on MRI after neurosurgical resection and radiotherapy with concurrent administration of temozolomide underwent DWI expressed as ADC map and MRS focused on concentration of N-acetylaspartate (NAA), choline (Cho), creatine (Cr), lactate (Lac), and lipids (Lip). An etiology of the lesion was then established by a finding on a subsequent MRI or by a biopsy and correlated with results of the investigated MR techniques. RESULTS: Compared to the pseudoprogression or radionecrosis, the relapse of HGG was characterized by significantly lower ADC values, lower NAA concentration, appearance of Lac+Lip spectra, as well as by non-significant increase in Cho. We found very high sensitivity and specificity of ADC median value (1220 x 10-6 mm2/sec) and Cho/NAA ratio (1.7) to designate the MRI lesion with gadolinium uptake as the HGG relapse. CONCLUSION: It can be concluded that DWI (ADC value) and MRS (mainly Cho/NAA ratio) have the ability for early non-invasive differentiation of the HGG relapse from the pseudoprogression or radionecrosis after the oncology treatment.

Citovat

JANČÁLEK, Radim, Martin BULIK, Tomáš KAZDA, Petr POSPÍŠIL, Pavel ŠLAMPA a Martin SMRČKA. DEVELOPING ROLE OF ADVANCED MRI TECHNIQUES FOR DIAGNOSIS OF HIGH-GRADE GLIOMA RELAPSE AFTER COMPLEX ONCOLOGY TREATMENT. In 11th Congress of the European Association of Neuro-Oncology. 2014. ISSN 1522-8517. Dostupné z: https://dx.doi.org/10.1093/neuonc/nou174.311.

@proceedings{1227636,
   author = {Jančálek, Radim and Bulik, Martin and Kazda, Tomáš and Pospíšil, Petr and Šlampa, Pavel and Smrčka, Martin},
   booktitle = {11th Congress of the European Association of Neuro-Oncology},
   doi = {http://dx.doi.org/10.1093/neuonc/nou174.311},
   keywords = {High-grade gliomas; brain tumors; MRI},
   language = {eng},
   title = {DEVELOPING ROLE OF ADVANCED MRI TECHNIQUES FOR DIAGNOSIS OF HIGH-GRADE GLIOMA RELAPSE AFTER COMPLEX ONCOLOGY TREATMENT},
   year = {2014}
}

TY  - CONF
ID  - 1227636
AU  - Jančálek, Radim - Bulik, Martin - Kazda, Tomáš - Pospíšil, Petr - Šlampa, Pavel - Smrčka, Martin
PY  - 2014
TI  - DEVELOPING ROLE OF ADVANCED MRI TECHNIQUES FOR DIAGNOSIS OF HIGH-GRADE GLIOMA RELAPSE AFTER COMPLEX ONCOLOGY TREATMENT
KW  - High-grade gliomas
KW  - brain tumors
KW  - MRI
N2  - PURPOSE/OBJECTIVES: High-grade gliomas (HGG) are the most common primary brain tumors of adults. Despite a multidisciplinary approach, HGGs frequently recur as a new gadolinium-enhanced MRI lesion at or near the site of the original tumor; thus, at the site of high-dose target volume for radiotherapy. An early differentiation between HGG relapse and changes in connection with oncology treatment (pseudoprogression or radionecrosis) is still problematic by commonly used diagnostic imaging techniques. The goal of our project is to verify whether a combination of diffusion-weighted MR imaging (DWI) and proton magnetic resonance spectroscopy (MRS) increase specificity of the conventional structural MRI with gadolinium for early non-invasive differentiation between of HGG relapse and pseudoprogression or radionecrosis. MATERIALS/METHODS: Patients (n= 26) with HGG and structural progression on MRI after neurosurgical resection and radiotherapy with concurrent administration of temozolomide underwent DWI expressed as ADC map and MRS focused on concentration of N-acetylaspartate (NAA), choline (Cho), creatine (Cr), lactate (Lac), and lipids (Lip). An etiology of the lesion was then established by a finding on a subsequent MRI or by a biopsy and correlated with results of the investigated MR techniques. RESULTS: Compared to the pseudoprogression or radionecrosis, the relapse of HGG was characterized by significantly lower ADC values, lower NAA concentration, appearance of Lac+Lip spectra, as well as by non-significant increase in Cho. We found very high sensitivity and specificity of ADC median value (1220 x 10-6 mm2/sec) and Cho/NAA ratio (1.7) to designate the MRI lesion with gadolinium uptake as the HGG relapse. CONCLUSION: It can be concluded that DWI (ADC value) and MRS (mainly Cho/NAA ratio) have the ability for early non-invasive differentiation of the HGG relapse from the pseudoprogression or radionecrosis after the oncology treatment.
ER  -

JANČÁLEK, Radim, Martin BULIK, Tomáš KAZDA, Petr POSPÍŠIL, Pavel ŠLAMPA a Martin SMRČKA. DEVELOPING ROLE OF ADVANCED MRI TECHNIQUES FOR DIAGNOSIS OF HIGH-GRADE GLIOMA RELAPSE AFTER COMPLEX ONCOLOGY TREATMENT. In \textit{11th Congress of the European Association of Neuro-Oncology}. 2014. ISSN~1522-8517. Dostupné z: https://dx.doi.org/10.1093/neuonc/nou174.311.

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