| KACEROVSKY, Marian, Ivana MUSILOVA, Bo JACOBSSON, Marcela DRAHOSOVA, Helena HORNYCHOVA, Petr JANKŮ, Martin PROCHAZKA, Ondrej SIMETKA a Ctirad ANDRYS. Cervical fluid IL-6 and IL-8 levels in pregnancies complicated by preterm prelabor rupture of membranes. Journal of Maternal-Fetal & Neonatal Medicine. London: INFORMA HEALTHCARE, 2015, roč. 28, č. 2, s. 134-140. ISSN 1476-7058. Dostupné z: https://dx.doi.org/10.3109/14767058.2014.908179. |
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@article{1228686,
author = {Kacerovsky, Marian and Musilova, Ivana and Jacobsson, Bo and Drahosova, Marcela and Hornychova, Helena and Janků, Petr and Prochazka, Martin and Simetka, Ondrej and Andrys, Ctirad},
article_location = {London},
article_number = {2},
doi = {http://dx.doi.org/10.3109/14767058.2014.908179},
keywords = {Chorioamnionitis; inflammatory response; non-invasive sample},
language = {eng},
issn = {1476-7058},
journal = {Journal of Maternal-Fetal & Neonatal Medicine},
title = {Cervical fluid IL-6 and IL-8 levels in pregnancies complicated by preterm prelabor rupture of membranes},
volume = {28},
year = {2015}
}
TY - JOUR
ID - 1228686
AU - Kacerovsky, Marian - Musilova, Ivana - Jacobsson, Bo - Drahosova, Marcela - Hornychova, Helena - Janků, Petr - Prochazka, Martin - Simetka, Ondrej - Andrys, Ctirad
PY - 2015
TI - Cervical fluid IL-6 and IL-8 levels in pregnancies complicated by preterm prelabor rupture of membranes
JF - Journal of Maternal-Fetal & Neonatal Medicine
VL - 28
IS - 2
SP - 134-140
EP - 134-140
PB - INFORMA HEALTHCARE
SN - 14767058
KW - Chorioamnionitis
KW - inflammatory response
KW - non-invasive sample
N2 - Objective: To determine the cervical fluid interleukin (IL)-6 and IL-8 levels in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) and the association of these interleukins with microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA). Methods: Sixty women with singleton pregnancies were included in this study. Cervical fluid was sampled at the time of admission using Dacron polyester swabs, which were placed into the endocervical canal for 20 s. IL-6 and IL-8 levels were determined by ELISA. The management of PPROM was active management (except for in pregnancies <28 weeks of gestation) and occurs not later than 72 h after the rupture of membranes. Result: The women with MIAC had higher IL-6 and IL-8 levels than did the women without MIAC (IL-6: p = 0.01; IL-8: p = 0.003). There was no difference in IL-6 levels between women with and without HCA (p = 0.37). The women with HCA had higher IL-8 levels only in the crude analysis (p = 0.01) but not after adjustment for gestational age (p = 0.06). The women with both MIAC and HCA had higher levels of IL-6 and IL-8 than did the other women (IL-6: p = 0.003; IL-8: p = 0.001). IL-8 level of 2653 pg/mL was found to be the best cut-off point in the identification of PPROM pregnancies complicated by both MIAC and HCA with a likelihood ratio of 24. Conclusions: The presence of MIAC is the most important factor impacting the local cervical inflammatory response, which is determined by IL-6 and IL-8 levels in the cervical fluid. IL-8 levels seem to be a promising non-invasive marker for the prediction of pregnancies complicated by the presence of both MIAC and HCA.
ER -
KACEROVSKY, Marian, Ivana MUSILOVA, Bo JACOBSSON, Marcela DRAHOSOVA, Helena HORNYCHOVA, Petr JANKŮ, Martin PROCHAZKA, Ondrej SIMETKA a Ctirad ANDRYS. Cervical fluid IL-6 and IL-8 levels in pregnancies complicated by preterm prelabor rupture of membranes. \textit{Journal of Maternal-Fetal \&{} Neonatal Medicine}. London: INFORMA HEALTHCARE, 2015, roč.~28, č.~2, s.~134-140. ISSN~1476-7058. Dostupné z: https://dx.doi.org/10.3109/14767058.2014.908179.
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