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@article{1228879, author = {Canesi, Laura and Frenzilli, Giada and Balbi, Teresa and Bernardeschi, Margherita and Ciacci, Claudia and Corsolini, Simonetta and Della Torre, Camilla and Fabbri, Rita and Faleri, Claudia and Focardi, Silvano and Guidi, Patrizia and Kočan, Anton and Marcomini, Antonio and Mariottini, Michela and Nigro, Marco and Pozo, Karla and Rocco, Lucia and Scarcelli, Vittoria and Smerilli, Arianna and Corsi, Ilaria}, article_location = {AMSTERDAM}, article_number = {AUG 20144}, doi = {http://dx.doi.org/10.1016/j.aquatox.2013.11.002}, keywords = {Nanoparticles; Titanium dioxide; Mytilus galloprovincialis; Biomarker; Dioxin}, language = {eng}, issn = {0166-445X}, journal = {Aquatic toxicology}, title = {Interactive effects of n-TiO2 and 2,3,7,8-TCDD on the marine bivalve Mytilus galloprovincialis}, url = {http://www.sciencedirect.com/science/article/pii/S0166445X13003081}, volume = {153}, year = {2014} }
TY - JOUR ID - 1228879 AU - Canesi, Laura - Frenzilli, Giada - Balbi, Teresa - Bernardeschi, Margherita - Ciacci, Claudia - Corsolini, Simonetta - Della Torre, Camilla - Fabbri, Rita - Faleri, Claudia - Focardi, Silvano - Guidi, Patrizia - Kočan, Anton - Marcomini, Antonio - Mariottini, Michela - Nigro, Marco - Pozo, Karla - Rocco, Lucia - Scarcelli, Vittoria - Smerilli, Arianna - Corsi, Ilaria PY - 2014 TI - Interactive effects of n-TiO2 and 2,3,7,8-TCDD on the marine bivalve Mytilus galloprovincialis JF - Aquatic toxicology VL - 153 IS - AUG 20144 SP - 53-65 EP - 53-65 PB - ELSEVIER SCIENCE BV SN - 0166445X KW - Nanoparticles KW - Titanium dioxide KW - Mytilus galloprovincialis KW - Biomarker KW - Dioxin UR - http://www.sciencedirect.com/science/article/pii/S0166445X13003081 L2 - http://www.sciencedirect.com/science/article/pii/S0166445X13003081 N2 - Despite the growing concern over the potential biological impact of nanoparticles (NPs) in the aquatic environment, little is known about their interactions with other pollutants. The bivalve Mytilus sp, largely utilized as a sentinel for marine contamination, has been shown to represent a significant target for different types of NP, including n-TiO2, one of the most widespread in use. In this work, the possible interactive effects of n-TiO2 and 2,3,7,8-TCDD, chosen as models of NP and organic contaminant, respectively, were investigated in Mytilus galloprovincialis. In vitro experiments with n-TiO2 and TCDD, alone and in combination, were carried out in different conditions (concentrations and times of exposure), depending on the target (hemocytes, gill cells and biopsies) and the endpoint measured. Mussels were also exposed in vivo to n-TiO2 (100 mu g L-1) or to TCDD (0.25 mu g L-1), alone and in combination, for 96 h. A wide range of biomarkers, from molecular to tissue level, were measured: lysosomal membrane stability and phagocytosis in hemocytes, ATP-binding cassette efflux transporters in gills (gene transcription and efflux activity), several biomarkers of genotoxicity in gill and digestive cells (DNA damage, random amplified polymorphic DNA-RAPD changes), lysosomal biomarkers and transcription of selected genes in the digestive gland. The results demonstrate that n-TiO2 and TCDD can exert synergistic or antagonistic effects, depending on experimental condition, cell/tissue and type of measured response. Some of these interactions may result from a significant increase in TCDD accumulation in whole mussel organisms in the presence of n-TiO2, indicating a Trojan horse effect. The results represent the most extensive data obtained so far on the sub-lethal effects of NPs and organic contaminants in aquatic organisms. Moreover, these data extend the knowledge on the molecular and cellular targets of NPs in bivalves. (C) 2013 Elsevier B.V. All rights reserved. ER -
CANESI, Laura, Giada FRENZILLI, Teresa BALBI, Margherita BERNARDESCHI, Claudia CIACCI, Simonetta CORSOLINI, Camilla DELLA TORRE, Rita FABBRI, Claudia FALERI, Silvano FOCARDI, Patrizia GUIDI, Anton KOČAN, Antonio MARCOMINI, Michela MARIOTTINI, Marco NIGRO, Karla POZO, Lucia ROCCO, Vittoria SCARCELLI, Arianna SMERILLI a Ilaria CORSI. Interactive effects of n-TiO2 and 2,3,7,8-TCDD on the marine bivalve Mytilus galloprovincialis. \textit{Aquatic toxicology}. AMSTERDAM: ELSEVIER SCIENCE BV, 2014, roč.~153, AUG 20144, s.~53-65. ISSN~0166-445X. Dostupné z: https://dx.doi.org/10.1016/j.aquatox.2013.11.002.
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