Sensory disturbances, inhibitory deficits, and the P50 wave in
schizophrenia

J 2014

Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia

VLČEK, Přemysl, Petr BOB a Jiří RABOCH

Základní údaje

Originální název

Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia

Autoři

VLČEK, Přemysl (203 Česká republika), Petr BOB (203 Česká republika, garant, domácí) a Jiří RABOCH (203 Česká republika)

Vydání

NEUROPSYCHIATRIC DISEASE AND TREATMENT, ALBANY, DOVE MEDICAL PRESS LTD, 2014, 1178-2021

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nový Zéland

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.741

Kód RIV

RIV/00216224:14740/14:00079334

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.2147/NDT.S64219

UT WoS

000339065100001

Klíčová slova anglicky

event-related potential; information overload; inhibition; P50 wave; schizophrenia; splitting

Štítky

kontrola MP, MP, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 3. 2015 11:25, Martina Prášilová

Anotace

V originále

Sensory gating disturbances in schizophrenia are often described as an inability to filter redundant sensory stimuli that typically manifest as inability to gate neuronal responses related to the P50 wave, characterizing a decreased ability of the brain to inhibit various responses to insignificant stimuli. It implicates various deficits of perceptual and attentional functions, and this inability to inhibit, or "gate", irrelevant sensory inputs leads to sensory and information overload that also may result in neuronal hyperexcitability related to disturbances of habituation mechanisms. These findings seem to be particularly important in the context of modern electrophysiological and neuroimaging data suggesting that the filtering deficits in schizophrenia are likely related to deficits in the integrity of connections between various brain areas. As a consequence, this brain disintegration produces disconnection of information, disrupted binding, and disintegration of consciousness that in terms of modern neuroscience could connect original Bleuler's concept of "split mind" with research of neural information integration.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

VLČEK, Přemysl, Petr BOB a Jiří RABOCH. Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia. NEUROPSYCHIATRIC DISEASE AND TREATMENT. ALBANY: DOVE MEDICAL PRESS LTD, 2014, roč. 10, July, s. 1309-1315. ISSN 1178-2021. Dostupné z: https://dx.doi.org/10.2147/NDT.S64219.

@article{1228894,
   author = {Vlček, Přemysl and Bob, Petr and Raboch, Jiří},
   article_location = {ALBANY},
   article_number = {July},
   doi = {http://dx.doi.org/10.2147/NDT.S64219},
   keywords = {event-related potential; information overload; inhibition; P50 wave; schizophrenia; splitting},
   language = {eng},
   issn = {1178-2021},
   journal = {NEUROPSYCHIATRIC DISEASE AND TREATMENT},
   title = {Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia},
   url = {http://www.dovepress.com/sensory-disturbances-inhibitory-deficits-and-the-p50-wave-in-schizophr-peer-reviewed-article-NDT},
   volume = {10},
   year = {2014}
}

TY  - JOUR
ID  - 1228894
AU  - Vlček, Přemysl - Bob, Petr - Raboch, Jiří
PY  - 2014
TI  - Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia
JF  - NEUROPSYCHIATRIC DISEASE AND TREATMENT
VL  - 10
IS  - July
SP  - 1309-1315
EP  - 1309-1315
PB  - DOVE MEDICAL PRESS LTD
SN  - 11782021
KW  - event-related potential
KW  - information overload
KW  - inhibition
KW  - P50 wave
KW  - schizophrenia
KW  - splitting
UR  - http://www.dovepress.com/sensory-disturbances-inhibitory-deficits-and-the-p50-wave-in-schizophr-peer-reviewed-article-NDT
L2  - http://www.dovepress.com/sensory-disturbances-inhibitory-deficits-and-the-p50-wave-in-schizophr-peer-reviewed-article-NDT
N2  - Sensory gating disturbances in schizophrenia are often described as an inability to filter redundant sensory stimuli that typically manifest as inability to gate neuronal responses related to the P50 wave, characterizing a decreased ability of the brain to inhibit various responses to insignificant stimuli. It implicates various deficits of perceptual and attentional functions, and this inability to inhibit, or "gate", irrelevant sensory inputs leads to sensory and information overload that also may result in neuronal hyperexcitability related to disturbances of habituation mechanisms. These findings seem to be particularly important in the context of modern electrophysiological and neuroimaging data suggesting that the filtering deficits in schizophrenia are likely related to deficits in the integrity of connections between various brain areas. As a consequence, this brain disintegration produces disconnection of information, disrupted binding, and disintegration of consciousness that in terms of modern neuroscience could connect original Bleuler's concept of "split mind" with research of neural information integration.
ER  -

VLČEK, Přemysl, Petr BOB a Jiří RABOCH. Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia. \textit{NEUROPSYCHIATRIC DISEASE AND TREATMENT}. ALBANY: DOVE MEDICAL PRESS LTD, 2014, roč.~10, July, s.~1309-1315. ISSN~1178-2021. Dostupné z: https://dx.doi.org/10.2147/NDT.S64219.

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