| CARVALHO, Raquel N., Augustine ARUKWE, Selim AIT-AISSA, Anne BADO-NILLES, Stefanio BALZAMO, Anders BAUN, Simshon BELKIN, Luděk BLÁHA, Francois BRION, Daniela CONTI, Nicolas CREUSOT, Yona ESSIG, Valentina E.V. FERRERO, Vesna FLANDER-PUTRLE, Maria FURHACKER, Regina GRILLARI-VOGLAUER, Christer HOGSTRAND, Adam JONÁŠ, Joubert B. KHARLYNGDOH, Robert LOOS, Anne-Katrine LUNDEBYE, Carina MODIG, Per-Erik OLSSON, Smitha PILLAI, Natasa POLAK, Monica POTALIVO, Wilfried SANCHEZ, Andrea SCHIFFERLI, Kristin SCHIRMER, Susanna SFORZINI, Stephen R. STURZENBAUM, Liv SOFTELAND, Valentina TURK, Aldo VIARENGO, Inge WERNER, Sharon YAGUR-KROLL, Radka ZOUNKOVÁ a Teresa LETTIERI. Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe Are They? Toxicological sciences. OXFORD: OXFORD UNIV PRESS, 2014, roč. 141, č. 1, s. 218-233. ISSN 1096-6080. Dostupné z: https://dx.doi.org/10.1093/toxsci/kfu118. |
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@article{1228978,
author = {Carvalho, Raquel N. and Arukwe, Augustine and AitandAissa, Selim and BadoandNilles, Anne and Balzamo, Stefanio and Baun, Anders and Belkin, Simshon and Bláha, Luděk and Brion, Francois and Conti, Daniela and Creusot, Nicolas and Essig, Yona and Ferrero, Valentina E.V. and FlanderandPutrle, Vesna and Furhacker, Maria and GrillariandVoglauer, Regina and Hogstrand, Christer and Jonáš, Adam and Kharlyngdoh, Joubert B. and Loos, Robert and Lundebye, AnneandKatrine and Modig, Carina and Olsson, PerandErik and Pillai, Smitha and Polak, Natasa and Potalivo, Monica and Sanchez, Wilfried and Schifferli, Andrea and Schirmer, Kristin and Sforzini, Susanna and Sturzenbaum, Stephen R. and Softeland, Liv and Turk, Valentina and Viarengo, Aldo and Werner, Inge and YagurandKroll, Sharon and Zounková, Radka and Lettieri, Teresa},
article_location = {OXFORD},
article_number = {1},
doi = {http://dx.doi.org/10.1093/toxsci/kfu118},
keywords = {bioassays; effects; mixtures; ecotoxicology; biomarkers},
language = {eng},
issn = {1096-6080},
journal = {Toxicological sciences},
title = {Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe Are They?},
url = {http://jech.bmj.com/content/early/2014/12/03/jech-2014-203913.full},
volume = {141},
year = {2014}
}
TY - JOUR
ID - 1228978
AU - Carvalho, Raquel N. - Arukwe, Augustine - Ait-Aissa, Selim - Bado-Nilles, Anne - Balzamo, Stefanio - Baun, Anders - Belkin, Simshon - Bláha, Luděk - Brion, Francois - Conti, Daniela - Creusot, Nicolas - Essig, Yona - Ferrero, Valentina E.V. - Flander-Putrle, Vesna - Furhacker, Maria - Grillari-Voglauer, Regina - Hogstrand, Christer - Jonáš, Adam - Kharlyngdoh, Joubert B. - Loos, Robert - Lundebye, Anne-Katrine - Modig, Carina - Olsson, Per-Erik - Pillai, Smitha - Polak, Natasa - Potalivo, Monica - Sanchez, Wilfried - Schifferli, Andrea - Schirmer, Kristin - Sforzini, Susanna - Sturzenbaum, Stephen R. - Softeland, Liv - Turk, Valentina - Viarengo, Aldo - Werner, Inge - Yagur-Kroll, Sharon - Zounková, Radka - Lettieri, Teresa
PY - 2014
TI - Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe Are They?
JF - Toxicological sciences
VL - 141
IS - 1
SP - 218-233
EP - 218-233
PB - OXFORD UNIV PRESS
SN - 10966080
KW - bioassays
KW - effects
KW - mixtures
KW - ecotoxicology
KW - biomarkers
UR - http://jech.bmj.com/content/early/2014/12/03/jech-2014-203913.full
L2 - http://jech.bmj.com/content/early/2014/12/03/jech-2014-203913.full
N2 - The risk posed by complex chemical mixtures in the environment to wildlife and humans is increasingly debated, but has been rarely tested under environmentally relevant scenarios. To address this issue, two mixtures of 14 or 19 substances of concern (pesticides, pharmaceuticals, heavy metals, polyaromatic hydrocarbons, a surfactant, and a plasticizer), each present at its safety limit concentration imposed by the European legislation, were prepared and tested for their toxic effects. The effects of the mixtures were assessed in 35 bioassays, based on 11 organisms representing different trophic levels. A consortium of 16 laboratories was involved in performing the bioassays. The mixtures elicited quantifiable toxic effects on some of the test systems employed, including i) changes in marine microbial composition, ii) microalgae toxicity, iii) immobilization in the crustacean Daphnia magna, iv) fish embryo toxicity, v) impaired frog embryo development, and vi) increased expression on oxidative stress-linked reporter genes. Estrogenic activity close to regulatory safety limit concentrations was uncovered by receptor-binding assays. The results highlight the need of precautionary actions on the assessment of chemical mixtures even in cases where individual toxicants are present at seemingly harmless concentrations.
ER -
CARVALHO, Raquel N., Augustine ARUKWE, Selim AIT-AISSA, Anne BADO-NILLES, Stefanio BALZAMO, Anders BAUN, Simshon BELKIN, Luděk BLÁHA, Francois BRION, Daniela CONTI, Nicolas CREUSOT, Yona ESSIG, Valentina E.V. FERRERO, Vesna FLANDER-PUTRLE, Maria FURHACKER, Regina GRILLARI-VOGLAUER, Christer HOGSTRAND, Adam JONÁŠ, Joubert B. KHARLYNGDOH, Robert LOOS, Anne-Katrine LUNDEBYE, Carina MODIG, Per-Erik OLSSON, Smitha PILLAI, Natasa POLAK, Monica POTALIVO, Wilfried SANCHEZ, Andrea SCHIFFERLI, Kristin SCHIRMER, Susanna SFORZINI, Stephen R. STURZENBAUM, Liv SOFTELAND, Valentina TURK, Aldo VIARENGO, Inge WERNER, Sharon YAGUR-KROLL, Radka ZOUNKOVÁ a Teresa LETTIERI. Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe Are They? \textit{Toxicological sciences}. OXFORD: OXFORD UNIV PRESS, 2014, roč.~141, č.~1, s.~218-233. ISSN~1096-6080. Dostupné z: https://dx.doi.org/10.1093/toxsci/kfu118.
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