Mixtures of Chemical Pollutants at European Legislation Safety
Concentrations: How Safe Are They?

J 2014

Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe Are They?

CARVALHO, Raquel N., Augustine ARUKWE, Selim AIT-AISSA, Anne BADO-NILLES, Stefanio BALZAMO et. al.

Základní údaje

Originální název

Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe Are They?

Autoři

CARVALHO, Raquel N. (380 Itálie), Augustine ARUKWE (578 Norsko), Selim AIT-AISSA (250 Francie), Anne BADO-NILLES (250 Francie), Stefanio BALZAMO (380 Itálie), Anders BAUN (208 Dánsko), Simshon BELKIN (376 Izrael), Luděk BLÁHA (203 Česká republika, domácí), Francois BRION (250 Francie), Daniela CONTI (380 Itálie), Nicolas CREUSOT (250 Francie), Yona ESSIG (826 Velká Británie a Severní Irsko), Valentina E.V. FERRERO (380 Itálie), Vesna FLANDER-PUTRLE (705 Slovinsko), Maria FURHACKER (40 Rakousko), Regina GRILLARI-VOGLAUER (40 Rakousko), Christer HOGSTRAND (826 Velká Británie a Severní Irsko), Adam JONÁŠ (203 Česká republika, domácí), Joubert B. KHARLYNGDOH (752 Švédsko), Robert LOOS (380 Itálie), Anne-Katrine LUNDEBYE (752 Švédsko), Carina MODIG (752 Švédsko), Per-Erik OLSSON (752 Švédsko), Smitha PILLAI (40 Rakousko), Natasa POLAK (826 Velká Británie a Severní Irsko), Monica POTALIVO (380 Itálie), Wilfried SANCHEZ (250 Francie), Andrea SCHIFFERLI (756 Švýcarsko), Kristin SCHIRMER (756 Švýcarsko), Susanna SFORZINI (756 Švýcarsko), Stephen R. STURZENBAUM (756 Švýcarsko), Liv SOFTELAND (578 Norsko), Valentina TURK (705 Slovinsko), Aldo VIARENGO (380 Itálie), Inge WERNER (756 Švýcarsko), Sharon YAGUR-KROLL (376 Izrael), Radka ZOUNKOVÁ (203 Česká republika, domácí) a Teresa LETTIERI (380 Itálie, garant)

Vydání

Toxicological sciences, OXFORD, OXFORD UNIV PRESS, 2014, 1096-6080

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30304 Public and environmental health

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.854

Kód RIV

RIV/00216224:14310/14:00079352

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1093/toxsci/kfu118

UT WoS

000342990200026

Klíčová slova anglicky

bioassays; effects; mixtures; ecotoxicology; biomarkers

Štítky

AKR, rivok

Příznaky

Recenzováno

Změněno: 20. 3. 2015 10:12, Ing. Filip Vaculovič

Anotace

V originále

The risk posed by complex chemical mixtures in the environment to wildlife and humans is increasingly debated, but has been rarely tested under environmentally relevant scenarios. To address this issue, two mixtures of 14 or 19 substances of concern (pesticides, pharmaceuticals, heavy metals, polyaromatic hydrocarbons, a surfactant, and a plasticizer), each present at its safety limit concentration imposed by the European legislation, were prepared and tested for their toxic effects. The effects of the mixtures were assessed in 35 bioassays, based on 11 organisms representing different trophic levels. A consortium of 16 laboratories was involved in performing the bioassays. The mixtures elicited quantifiable toxic effects on some of the test systems employed, including i) changes in marine microbial composition, ii) microalgae toxicity, iii) immobilization in the crustacean Daphnia magna, iv) fish embryo toxicity, v) impaired frog embryo development, and vi) increased expression on oxidative stress-linked reporter genes. Estrogenic activity close to regulatory safety limit concentrations was uncovered by receptor-binding assays. The results highlight the need of precautionary actions on the assessment of chemical mixtures even in cases where individual toxicants are present at seemingly harmless concentrations.

Citovat

CARVALHO, Raquel N., Augustine ARUKWE, Selim AIT-AISSA, Anne BADO-NILLES, Stefanio BALZAMO, Anders BAUN, Simshon BELKIN, Luděk BLÁHA, Francois BRION, Daniela CONTI, Nicolas CREUSOT, Yona ESSIG, Valentina E.V. FERRERO, Vesna FLANDER-PUTRLE, Maria FURHACKER, Regina GRILLARI-VOGLAUER, Christer HOGSTRAND, Adam JONÁŠ, Joubert B. KHARLYNGDOH, Robert LOOS, Anne-Katrine LUNDEBYE, Carina MODIG, Per-Erik OLSSON, Smitha PILLAI, Natasa POLAK, Monica POTALIVO, Wilfried SANCHEZ, Andrea SCHIFFERLI, Kristin SCHIRMER, Susanna SFORZINI, Stephen R. STURZENBAUM, Liv SOFTELAND, Valentina TURK, Aldo VIARENGO, Inge WERNER, Sharon YAGUR-KROLL, Radka ZOUNKOVÁ a Teresa LETTIERI. Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe Are They? Toxicological sciences. OXFORD: OXFORD UNIV PRESS, 2014, roč. 141, č. 1, s. 218-233. ISSN 1096-6080. Dostupné z: https://dx.doi.org/10.1093/toxsci/kfu118.

@article{1228978,
   author = {Carvalho, Raquel N. and Arukwe, Augustine and AitandAissa, Selim and BadoandNilles, Anne and Balzamo, Stefanio and Baun, Anders and Belkin, Simshon and Bláha, Luděk and Brion, Francois and Conti, Daniela and Creusot, Nicolas and Essig, Yona and Ferrero, Valentina E.V. and FlanderandPutrle, Vesna and Furhacker, Maria and GrillariandVoglauer, Regina and Hogstrand, Christer and Jonáš, Adam and Kharlyngdoh, Joubert B. and Loos, Robert and Lundebye, AnneandKatrine and Modig, Carina and Olsson, PerandErik and Pillai, Smitha and Polak, Natasa and Potalivo, Monica and Sanchez, Wilfried and Schifferli, Andrea and Schirmer, Kristin and Sforzini, Susanna and Sturzenbaum, Stephen R. and Softeland, Liv and Turk, Valentina and Viarengo, Aldo and Werner, Inge and YagurandKroll, Sharon and Zounková, Radka and Lettieri, Teresa},
   article_location = {OXFORD},
   article_number = {1},
   doi = {http://dx.doi.org/10.1093/toxsci/kfu118},
   keywords = {bioassays; effects; mixtures; ecotoxicology; biomarkers},
   language = {eng},
   issn = {1096-6080},
   journal = {Toxicological sciences},
   title = {Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe Are They?},
   url = {http://jech.bmj.com/content/early/2014/12/03/jech-2014-203913.full},
   volume = {141},
   year = {2014}
}

TY  - JOUR
ID  - 1228978
AU  - Carvalho, Raquel N. - Arukwe, Augustine - Ait-Aissa, Selim - Bado-Nilles, Anne - Balzamo, Stefanio - Baun, Anders - Belkin, Simshon - Bláha, Luděk - Brion, Francois - Conti, Daniela - Creusot, Nicolas - Essig, Yona - Ferrero, Valentina E.V. - Flander-Putrle, Vesna - Furhacker, Maria - Grillari-Voglauer, Regina - Hogstrand, Christer - Jonáš, Adam - Kharlyngdoh, Joubert B. - Loos, Robert - Lundebye, Anne-Katrine - Modig, Carina - Olsson, Per-Erik - Pillai, Smitha - Polak, Natasa - Potalivo, Monica - Sanchez, Wilfried - Schifferli, Andrea - Schirmer, Kristin - Sforzini, Susanna - Sturzenbaum, Stephen R. - Softeland, Liv - Turk, Valentina - Viarengo, Aldo - Werner, Inge - Yagur-Kroll, Sharon - Zounková, Radka - Lettieri, Teresa
PY  - 2014
TI  - Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe Are They?
JF  - Toxicological sciences
VL  - 141
IS  - 1
SP  - 218-233
EP  - 218-233
PB  - OXFORD UNIV PRESS
SN  - 10966080
KW  - bioassays
KW  - effects
KW  - mixtures
KW  - ecotoxicology
KW  - biomarkers
UR  - http://jech.bmj.com/content/early/2014/12/03/jech-2014-203913.full
L2  - http://jech.bmj.com/content/early/2014/12/03/jech-2014-203913.full
N2  - The risk posed by complex chemical mixtures in the environment to wildlife and humans is increasingly debated, but has been rarely tested under environmentally relevant scenarios. To address this issue, two mixtures of 14 or 19 substances of concern (pesticides, pharmaceuticals, heavy metals, polyaromatic hydrocarbons, a surfactant, and a plasticizer), each present at its safety limit concentration imposed by the European legislation, were prepared and tested for their toxic effects. The effects of the mixtures were assessed in 35 bioassays, based on 11 organisms representing different trophic levels. A consortium of 16 laboratories was involved in performing the bioassays. The mixtures elicited quantifiable toxic effects on some of the test systems employed, including i) changes in marine microbial composition, ii) microalgae toxicity, iii) immobilization in the crustacean Daphnia magna, iv) fish embryo toxicity, v) impaired frog embryo development, and vi) increased expression on oxidative stress-linked reporter genes. Estrogenic activity close to regulatory safety limit concentrations was uncovered by receptor-binding assays. The results highlight the need of precautionary actions on the assessment of chemical mixtures even in cases where individual toxicants are present at seemingly harmless concentrations.
ER  -

CARVALHO, Raquel N., Augustine ARUKWE, Selim AIT-AISSA, Anne BADO-NILLES, Stefanio BALZAMO, Anders BAUN, Simshon BELKIN, Luděk BLÁHA, Francois BRION, Daniela CONTI, Nicolas CREUSOT, Yona ESSIG, Valentina E.V. FERRERO, Vesna FLANDER-PUTRLE, Maria FURHACKER, Regina GRILLARI-VOGLAUER, Christer HOGSTRAND, Adam JONÁŠ, Joubert B. KHARLYNGDOH, Robert LOOS, Anne-Katrine LUNDEBYE, Carina MODIG, Per-Erik OLSSON, Smitha PILLAI, Natasa POLAK, Monica POTALIVO, Wilfried SANCHEZ, Andrea SCHIFFERLI, Kristin SCHIRMER, Susanna SFORZINI, Stephen R. STURZENBAUM, Liv SOFTELAND, Valentina TURK, Aldo VIARENGO, Inge WERNER, Sharon YAGUR-KROLL, Radka ZOUNKOVÁ a Teresa LETTIERI. Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe Are They? \textit{Toxicological sciences}. OXFORD: OXFORD UNIV PRESS, 2014, roč.~141, č.~1, s.~218-233. ISSN~1096-6080. Dostupné z: https://dx.doi.org/10.1093/toxsci/kfu118.

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