CHAP domain of tail-associated protein from phage 812 and its
lytic activity against Staphylococcus aureus

J 2014

CHAP domain of tail-associated protein from phage 812 and its lytic activity against Staphylococcus aureus

BENEŠÍK, Martin, Radka DOPITOVÁ, Lubomír JANDA, Jiří DOŠKAŘ, Marek MOŠA et. al.

Základní údaje

Originální název

CHAP domain of tail-associated protein from phage 812 and its lytic activity against Staphylococcus aureus

Autoři

BENEŠÍK, Martin, Radka DOPITOVÁ, Lubomír JANDA, Jiří DOŠKAŘ, Marek MOŠA, Josef BOŠTÍK a Roman PANTŮČEK

Vydání

Russian Journal of Infection and Immunity, Sankt Peterburg, InformMed, 2014, 2220-7619

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Rusko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Organizační jednotka

Přírodovědecká fakulta

Štítky

Změněno: 5. 3. 2015 17:04, prof. RNDr. Roman Pantůček, Ph.D.

Anotace

V originále

The increasing number of pathogenic bacteria resistant to antimicrobial agents is a serious public health problem. Phage therapy appears to be a suitable alternative to antibiotics treatment. In history, it was envisaged to use bacteriophages as antimicrobial agents but recently, the research focus on phage encoded antimicrobial proteins. Bacteriophages produce lytic enzymes two times during their lytic cycle. In this study we focused on tail hydrolase of polyvalent staphylococcal bacteriophage 812, a member of SPO1-like viruses from family Myoviridae. This enzyme play role in the beginning of phage lytic cycle. It disturbs bacteria cell wall for injection of phage DNA into bacterial cell. This lytic enzyme can be possible use as antimicrobial agents against S. aureus bacterial cells.

Návaznosti

TA01010405, projekt VaV

Název: Výzkum stafylokokových bakteriofágových mutant s širokým spektrem hostitelů (Akronym: TAČR/IMUNA-1)

Investor: Technologická agentura ČR, Výzkum stafylokokových bakteriofágových mutant s širokým spektrem hostitelů

Citovat

BENEŠÍK, Martin, Radka DOPITOVÁ, Lubomír JANDA, Jiří DOŠKAŘ, Marek MOŠA, Josef BOŠTÍK a Roman PANTŮČEK. CHAP domain of tail-associated protein from phage 812 and its lytic activity against Staphylococcus aureus. Russian Journal of Infection and Immunity. Sankt Peterburg: InformMed, 2014, roč. 4, S1, s. 33. ISSN 2220-7619.

@article{1229241,
   author = {Benešík, Martin and Dopitová, Radka and Janda, Lubomír and Doškař, Jiří and Moša, Marek and Boštík, Josef and Pantůček, Roman},
   article_location = {Sankt Peterburg},
   article_number = {S1},
   language = {eng},
   issn = {2220-7619},
   journal = {Russian Journal of Infection and Immunity},
   title = {CHAP domain of tail-associated protein from phage 812 and its lytic activity against Staphylococcus aureus},
   url = {http://iimmun.ru/index.php/iimm},
   volume = {4},
   year = {2014}
}

TY  - JOUR
ID  - 1229241
AU  - Benešík, Martin - Dopitová, Radka - Janda, Lubomír - Doškař, Jiří - Moša, Marek - Boštík, Josef - Pantůček, Roman
PY  - 2014
TI  - CHAP domain of tail-associated protein from phage 812 and its lytic activity against Staphylococcus aureus
JF  - Russian Journal of Infection and Immunity
VL  - 4
IS  - S1
SP  - 33
EP  - 33
PB  - InformMed
SN  - 22207619
UR  - http://iimmun.ru/index.php/iimm
N2  - The increasing number of pathogenic bacteria resistant to antimicrobial agents is a serious public health problem. Phage therapy appears to be a suitable alternative to antibiotics treatment. In history, it was envisaged to use bacteriophages as antimicrobial agents but recently, the research focus on phage encoded antimicrobial proteins. Bacteriophages produce lytic enzymes two times during their lytic cycle. In this study we focused on tail hydrolase of polyvalent staphylococcal bacteriophage 812, a member of SPO1-like viruses from family Myoviridae. This enzyme play role in the beginning of phage lytic cycle. It disturbs bacteria cell wall for injection of phage DNA into bacterial cell. This lytic enzyme can be possible use as antimicrobial agents against S. aureus bacterial cells.
ER  -

BENEŠÍK, Martin, Radka DOPITOVÁ, Lubomír JANDA, Jiří DOŠKAŘ, Marek MOŠA, Josef BOŠTÍK a Roman PANTŮČEK. CHAP domain of tail-associated protein from phage 812 and its lytic activity against Staphylococcus aureus. \textit{Russian Journal of Infection and Immunity}. Sankt Peterburg: InformMed, 2014, roč.~4, S1, s.~33. ISSN~2220-7619.

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