Electrochemistry of Nonconjugated Proteins and Glycoproteins.
Toward Sensors for Biomedicine and Glycomics

J 2015

Electrochemistry of Nonconjugated Proteins and Glycoproteins. Toward Sensors for Biomedicine and Glycomics

PALEČEK, Emil, Ján TKÁČ, Martin BARTOŠÍK, Tomáš BERTÓK, Veronika OSTATNÁ et. al.

Základní údaje

Originální název

Electrochemistry of Nonconjugated Proteins and Glycoproteins. Toward Sensors for Biomedicine and Glycomics

Název česky

Elektrochemie nekonjugovaných proteinů a glykoproteinů. K sensorům pro biomedicínu a glykomiku.

Autoři

PALEČEK, Emil (203 Česká republika), Ján TKÁČ (703 Slovensko), Martin BARTOŠÍK (703 Slovensko), Tomáš BERTÓK (703 Slovensko), Veronika OSTATNÁ (703 Slovensko) a Jan PALEČEK (203 Česká republika, garant, domácí)

Vydání

Chemical Reviews, Washington D.C. American Chemical Society, 2015, 0009-2665

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10405 Electrochemistry

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 37.369

Kód RIV

RIV/00216224:14740/15:00080704

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1021/cr500279h

UT WoS

000351187400001

Klíčová slova anglicky

Electrochemistry; Proteins; Glycoproteins; Sensors

Štítky

protein analysis, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 3. 2017 21:00, doc. Mgr. Jan Paleček, Dr. rer. nat.

Anotace

V originále

In this review, we wish to show that in the recent years a significant progress was done in the EC analysis of practically all proteins, based on electroactivity of amino acid (aa) residues in proteins. Also electrochemistry of polysaccharides, oligosaccharides and glycoproteins greatly advanced in creating important steps for its larger application in the glycoprotein research. In recent decades, a great effort was devoted to the discovery and application of biomarkers for analysis of different diseases, including cancer. In the following paragraphs, special attention will be paid (i) to intrinsic electroactivity of peptides and proteins, including the sensitivity to changes in protein 3D structures, as well as to recent advances in EC investigations of DNA-protein interactions, (ii) to intrinsic electroactivity of glycans and polysaccharides, advances in EC detection of lectin-glycoprotein interactions and to introduction of electroactive labels to polysaccharides and glycans and finally (iii) to EC detection of protein biomarkers, based predominantly on application of antibodies in immunoassays, nucleic acid and peptide aptamers for construction of aptasensors, and lectin biosensors for detection of glycoprotein biomarkers.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

GA13-00774S, projekt VaV

Název: Úloha proteinů Nse, podjednotek komplexu SMC5/6, v procesech stabilizujících pozastavené replikační vidlice

Investor: Grantová agentura ČR, Úloha proteinu Nse, podjednotek komplexu SMC5/6, v procesech stabilizujících pozastavené replikacní vidlice

Citovat

PALEČEK, Emil, Ján TKÁČ, Martin BARTOŠÍK, Tomáš BERTÓK, Veronika OSTATNÁ a Jan PALEČEK. Electrochemistry of Nonconjugated Proteins and Glycoproteins. Toward Sensors for Biomedicine and Glycomics. Chemical Reviews. Washington D.C.: American Chemical Society, 2015, roč. 115, č. 5, s. 2045-2108. ISSN 0009-2665. Dostupné z: https://dx.doi.org/10.1021/cr500279h.

@article{1230071,
   author = {Paleček, Emil and Tkáč, Ján and Bartošík, Martin and Bertók, Tomáš and Ostatná, Veronika and Paleček, Jan},
   article_location = {Washington D.C.},
   article_number = {5},
   doi = {http://dx.doi.org/10.1021/cr500279h},
   keywords = {Electrochemistry; Proteins; Glycoproteins; Sensors},
   language = {eng},
   issn = {0009-2665},
   journal = {Chemical Reviews},
   title = {Electrochemistry of Nonconjugated Proteins and Glycoproteins. Toward Sensors for Biomedicine and Glycomics},
   url = {http://pubs.acs.org/doi/pdf/10.1021/cr500279h},
   volume = {115},
   year = {2015}
}

TY  - JOUR
ID  - 1230071
AU  - Paleček, Emil - Tkáč, Ján - Bartošík, Martin - Bertók, Tomáš - Ostatná, Veronika - Paleček, Jan
PY  - 2015
TI  - Electrochemistry of Nonconjugated Proteins and Glycoproteins. Toward Sensors for Biomedicine and Glycomics
JF  - Chemical Reviews
VL  - 115
IS  - 5
SP  - 2045-2108
EP  - 2045-2108
PB  - American Chemical Society
SN  - 00092665
KW  - Electrochemistry
KW  - Proteins
KW  - Glycoproteins
KW  - Sensors
UR  - http://pubs.acs.org/doi/pdf/10.1021/cr500279h
L2  - http://pubs.acs.org/doi/pdf/10.1021/cr500279h
N2  - In this review, we wish to show that in the recent years a significant progress was done in the EC analysis of practically all proteins, based on electroactivity of amino acid (aa) residues in proteins. Also electrochemistry of polysaccharides, oligosaccharides and glycoproteins greatly advanced in creating important steps for its larger application in the glycoprotein research. In recent decades, a great effort was devoted to the discovery and application of biomarkers for analysis of different diseases, including cancer. In the following paragraphs, special attention will be paid (i) to intrinsic electroactivity of peptides and proteins, including the sensitivity to changes in protein 3D structures, as well as to recent advances in EC investigations of DNA-protein interactions, (ii) to intrinsic electroactivity of glycans and polysaccharides, advances in EC detection of lectin-glycoprotein interactions and to introduction of electroactive labels to polysaccharides and glycans and finally (iii) to EC detection of protein biomarkers, based predominantly on application of antibodies in immunoassays, nucleic acid and peptide aptamers for construction of aptasensors, and lectin biosensors for detection of glycoprotein biomarkers.
ER  -

PALEČEK, Emil, Ján TKÁČ, Martin BARTOŠÍK, Tomáš BERTÓK, Veronika OSTATNÁ a Jan PALEČEK. Electrochemistry of Nonconjugated Proteins and Glycoproteins. Toward Sensors for Biomedicine and Glycomics. \textit{Chemical Reviews}. Washington D.C.: American Chemical Society, 2015, roč.~115, č.~5, s.~2045-2108. ISSN~0009-2665. Dostupné z: https://dx.doi.org/10.1021/cr500279h.

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