The path to life's origins. Remaining hurdles

J 2014

The path to life's origins. Remaining hurdles

MAURO, Di E., R. SALADINO a Eduard Nikolajevič TRIFONOV

Základní údaje

Originální název

The path to life's origins. Remaining hurdles

Autoři

MAURO, Di E. (380 Itálie), R. SALADINO (380 Itálie) a Eduard Nikolajevič TRIFONOV (376 Izrael, garant, domácí)

Vydání

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, PHILADELPHIA, TAYLOR & FRANCIS INC, 2014, 0739-1102

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.919

Kód RIV

RIV/00216224:14740/14:00079591

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1080/07391102.2013.783509

UT WoS

000329899500001

Klíčová slova anglicky

origin of life; simplissimus; RNA replicator; abiotic start; self-replication; border chemistry; life; formamide reactions

Štítky

kontrola MP, MP, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 3. 2015 11:14, Martina Prášilová

Anotace

V originále

Recent progress in abiotic syntheses, especially self-catalytic syntheses, as well as theoretical breakthroughs such as reconstruction of events of early molecular evolution and tracing repeat expansions in contemporary genomes, converge to a rather simple possible scenario of origin of life, notwithstanding the enormity of the problem. The scenario includes self-replicating RNA duplexes, supplemented by monomers and high-energy compounds that, as demonstrated or assumed, can all be synthesized abiotically. The self-replication would proceed with occasional mutational changes, propagated in later cycles. This audacious, as it may seem, walk toward the life origin already involves many laboratories, each exploring its own scenario. The one suggested in this outline seems to the authors well justified to engage in, while bypassing few steps to deal with later.

Citovat

MAURO, Di E., R. SALADINO a Eduard Nikolajevič TRIFONOV. The path to life's origins. Remaining hurdles. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS. PHILADELPHIA: TAYLOR & FRANCIS INC, 2014, roč. 32, č. 4, s. 512-522. ISSN 0739-1102. Dostupné z: https://dx.doi.org/10.1080/07391102.2013.783509.

@article{1230817,
   author = {Mauro, Di E. and Saladino, R. and Trifonov, Eduard Nikolajevič},
   article_location = {PHILADELPHIA},
   article_number = {4},
   doi = {http://dx.doi.org/10.1080/07391102.2013.783509},
   keywords = {origin of life; simplissimus; RNA replicator; abiotic start; self-replication; border chemistry; life; formamide reactions},
   language = {eng},
   issn = {0739-1102},
   journal = {JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS},
   title = {The path to life's origins. Remaining hurdles},
   url = {http://www.tandfonline.com/doi/pdf/10.1080/07391102.2013.783509#.VQlPoOFFrs4},
   volume = {32},
   year = {2014}
}

TY  - JOUR
ID  - 1230817
AU  - Mauro, Di E. - Saladino, R. - Trifonov, Eduard Nikolajevič
PY  - 2014
TI  - The path to life's origins. Remaining hurdles
JF  - JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
VL  - 32
IS  - 4
SP  - 512-522
EP  - 512-522
PB  - TAYLOR & FRANCIS INC
SN  - 07391102
KW  - origin of life
KW  - simplissimus
KW  - RNA replicator
KW  - abiotic start
KW  - self-replication
KW  - border chemistry
KW  - life
KW  - formamide reactions
UR  - http://www.tandfonline.com/doi/pdf/10.1080/07391102.2013.783509#.VQlPoOFFrs4
L2  - http://www.tandfonline.com/doi/pdf/10.1080/07391102.2013.783509#.VQlPoOFFrs4
N2  - Recent progress in abiotic syntheses, especially self-catalytic syntheses, as well as theoretical breakthroughs such as reconstruction of events of early molecular evolution and tracing repeat expansions in contemporary genomes, converge to a rather simple possible scenario of origin of life, notwithstanding the enormity of the problem. The scenario includes self-replicating RNA duplexes, supplemented by monomers and high-energy compounds that, as demonstrated or assumed, can all be synthesized abiotically. The self-replication would proceed with occasional mutational changes, propagated in later cycles. This audacious, as it may seem, walk toward the life origin already involves many laboratories, each exploring its own scenario. The one suggested in this outline seems to the authors well justified to engage in, while bypassing few steps to deal with later.
ER  -

MAURO, Di E., R. SALADINO a Eduard Nikolajevič TRIFONOV. The path to life's origins. Remaining hurdles. \textit{JOURNAL OF BIOMOLECULAR STRUCTURE \&{}amp; DYNAMICS}. PHILADELPHIA: TAYLOR \&{}amp; FRANCIS INC, 2014, roč.~32, č.~4, s.~512-522. ISSN~0739-1102. Dostupné z: https://dx.doi.org/10.1080/07391102.2013.783509.

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