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@article{1231045,
author = {Šebrlová, Kristýna and Peš, Ondřej and Slaninová, Iva and Vymazal, Ondřej and Kantorová, Jana and Táborská, Eva},
article_location = {Berlin},
article_number = {5},
doi = {http://dx.doi.org/10.1515/chempap-2015-0083},
keywords = {Stylophorum lasiocarpum; traditional Chinese medicine; vegetation period; benzophenanthridine; LC MS; cytotoxicity},
language = {eng},
issn = {0366-6352},
journal = {Chemical papers},
title = {Seasonal variation in alkaloid composition and antiproliferative activity of Stylophorum lasiocarpum (Oliv.) Fedde},
url = {http://www.chemicalpapers.com/?id=7&paper=8475},
volume = {69},
year = {2015}
}
TY - JOUR
ID - 1231045
AU - Šebrlová, Kristýna - Peš, Ondřej - Slaninová, Iva - Vymazal, Ondřej - Kantorová, Jana - Táborská, Eva
PY - 2015
TI - Seasonal variation in alkaloid composition and antiproliferative activity of Stylophorum lasiocarpum (Oliv.) Fedde
JF - Chemical papers
VL - 69
IS - 5
SP - 698-708
EP - 698-708
PB - WALTER DE GRUYTER GMBH
SN - 03666352
KW - Stylophorum lasiocarpum
KW - traditional Chinese medicine
KW - vegetation period
KW - benzophenanthridine
KW - LC MS
KW - cytotoxicity
UR - http://www.chemicalpapers.com/?id=7&paper=8475
N2 - Stylophorum lasiocarpum (Oliv.) Fedde (Papaveraceae) belongs to traditional Chinese medicine herbs but there was minimal information on the content of alkaloids in this plant. Extracts from the aerial part and roots were examined by liquid chromatography with UV and mass spectrometric detection, with nineteen alkaloids identified. Changes in alkaloid content over the entire vegetation period of a one- and two-year old plant were studied. The protoberberine alkaloids, coptisine and stylopine, were found to be the main substances in extracts of the aerial part irrespective of the plant’s age and time of harvest. Variable amounts of protopine, sanguinarine, chelerythrine, chelirubine, macarpine, chelilutine and berberine were also recorded in the aerial part. The roots contained significantly larger quantities of all alkaloids than the aerial part with the levels of most alkaloids varying from May to October, peaking in the middle of the vegetation period. Coptisine was the dominant alkaloid in all samples. The antiproliferative activities of the root extract and of seven individual alkaloids were tested on A375 human malignant melanoma cells. The significant dose-dependent toxicity of the root extract was attributed largely to the quaternary benzo[c]phenanthridine alkaloids, macarpine and sanguinarine.
ER -
ŠEBRLOVÁ, Kristýna, Ondřej PEŠ, Iva SLANINOVÁ, Ondřej VYMAZAL, Jana KANTOROVÁ and Eva TÁBORSKÁ. Seasonal variation in alkaloid composition and antiproliferative activity of Stylophorum lasiocarpum (Oliv.) Fedde. \textit{Chemical papers}. Berlin: WALTER DE GRUYTER GMBH, 2015, vol.~69, No~5, p.~698-708. ISSN~0366-6352. Available from: https://dx.doi.org/10.1515/chempap-2015-0083.
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