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@article{1231973,
author = {Šerý, Omar and Hlinecká, Lýdia and Balcar, Vladimír and Janout, Vladimír and Povová, Jana},
article_number = {8},
keywords = {ApoE; hypertension; diabetes; stroke; association; polymorphism},
language = {eng},
issn = {0172-780X},
journal = {Neuroendocrinology Letters},
title = {Diabetes, hypertension and stroke - does Alzheimer protect you?},
volume = {35},
year = {2014}
}
TY - JOUR
ID - 1231973
AU - Šerý, Omar - Hlinecká, Lýdia - Balcar, Vladimír - Janout, Vladimír - Povová, Jana
PY - 2014
TI - Diabetes, hypertension and stroke - does Alzheimer protect you?
JF - Neuroendocrinology Letters
VL - 35
IS - 8
SP - 691-696
EP - 691-696
PB - Edition Medizin
SN - 0172780X
KW - ApoE
KW - hypertension
KW - diabetes
KW - stroke
KW - association
KW - polymorphism
N2 - OBJECTIVE: The aim of our current research project is to further evaluate the role of risk factors in the pathogenesis of Alzheimer's disease; these include genetic variations, environmental factors and lifestyle issues. METHODS: We have been conducting an association study on 373 patients with Alzheimer's disease and 286 unrelated control individuals. The occurrence and the age of onset of diabetes and cardiovascular diseases were evaluated in both groups. Apolipoprotein E genotype was analyzed in all subjects by PCR method. RESULTS: We report that, in Czech population carrying ApoE4 allele increases risk of Alzheimer's disease 2.1-fold and genotype E4E4 increases the risk 8.4-fold. We have also identified a significant association between ApoE4 allele, Alzheimer's disease and hypertension. Hypertensive subjects with the ApoE4 allele have 1.5-fold greater risk of Alzheimer's disease. Thus, hypertension together with ApoE4 allele translates into 1.5-fold higher risk of AD. The most intriguing original finding in the present study is that Alzheimer's disease patients have significantly later onset of diabetes, hypertension and stroke in comparison with control subjects. This effect was not influenced by ApoE genotype. The diabetes appeared in AD patients on average more than 10 years later than in the control subjects (p<0.0001), hypertension was diagnosed 14 years later in AD patients (p<0.00001) and stroke occurred on average 6 years later (p<0.005), compared to the control group. CONCLUSIONS: Overall, in addition to the above novel findings, our study expands the data base on risk factors that could be used in near future when testing for the genetic risk of Alzheimer's disease.
ER -
ŠERÝ, Omar, Lýdia HLINECKÁ, Vladimír BALCAR, Vladimír JANOUT and Jana POVOVÁ. Diabetes, hypertension and stroke - does Alzheimer protect you? \textit{Neuroendocrinology Letters}. Edition Medizin, 2014, vol.~35, No~8, p.~691-696. ISSN~0172-780X.
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