| BAJARD-EŠNER, Lola, L.G. MORELLI, S. ARES, J. PECREAUX, F. JULICHER and A.C. OATES. Wnt-regulated dynamics of positional information in zebrafish somitogenesis. Development. Cambridge: Company of Biologists, 2014, vol. 141, No 6, p. 1381-1391. ISSN 0950-1991. Available from: https://dx.doi.org/10.1242/dev.093435. |
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@article{1232471,
author = {BajardandEšner, Lola and Morelli, L.G. and Ares, S. and Pecreaux, J. and Julicher, F. and Oates, A.C.},
article_location = {Cambridge},
article_number = {6},
doi = {http://dx.doi.org/10.1242/dev.093435},
keywords = {Fgf signaling; Wnt signaling; Embryonic elongation; Segmentation clock; Signal gradient; Time-lapse microscopy},
language = {eng},
issn = {0950-1991},
journal = {Development},
title = {Wnt-regulated dynamics of positional information in zebrafish somitogenesis},
url = {http://dev.biologists.org/content/141/6/1381.long},
volume = {141},
year = {2014}
}
TY - JOUR
ID - 1232471
AU - Bajard-Ešner, Lola - Morelli, L.G. - Ares, S. - Pecreaux, J. - Julicher, F. - Oates, A.C.
PY - 2014
TI - Wnt-regulated dynamics of positional information in zebrafish somitogenesis
JF - Development
VL - 141
IS - 6
SP - 1381-1391
EP - 1381-1391
PB - Company of Biologists
SN - 09501991
KW - Fgf signaling
KW - Wnt signaling
KW - Embryonic elongation
KW - Segmentation clock
KW - Signal gradient
KW - Time-lapse microscopy
UR - http://dev.biologists.org/content/141/6/1381.long
L2 - http://dev.biologists.org/content/141/6/1381.long
N2 - How signaling gradients supply positional information in a field of moving cells is an unsolved question in patterning and morphogenesis. Here, we ask how a Wnt signaling gradient regulates the dynamics of a wavefront of cellular change in a flow of cells during somitogenesis. Using time-controlled perturbations of Wnt signaling in the zebrafish embryo, we changed segment length without altering the rate of somite formation or embryonic elongation. This result implies specific Wnt regulation of the wavefront velocity. The observed Wnt signaling gradient dynamics and timing of downstream events support a model for wavefront regulation in which cell flow plays a dominant role in transporting positional information.
ER -
BAJARD-EŠNER, Lola, L.G. MORELLI, S. ARES, J. PECREAUX, F. JULICHER and A.C. OATES. Wnt-regulated dynamics of positional information in zebrafish somitogenesis. \textit{Development}. Cambridge: Company of Biologists, 2014, vol.~141, No~6, p.~1381-1391. ISSN~0950-1991. Available from: https://dx.doi.org/10.1242/dev.093435.
|
