C 2014

Modern Techniques of Epileptic Focus Localization

MARTINKOVIC, L., H. HECIMOVIC, V. SULC, Radek MAREČEK, Petr MARUSIČ et. al.

Basic information

Original name

Modern Techniques of Epileptic Focus Localization

Authors

MARTINKOVIC, L. (203 Czech Republic), H. HECIMOVIC (191 Croatia), V. SULC (203 Czech Republic), Radek MAREČEK (203 Czech Republic, guarantor, belonging to the institution) and Petr MARUSIČ (203 Czech Republic)

Edition

114. vyd. SAN DIEGO, International Review of Neurobiology, p. 245-278, 34 pp. Modern Concepts of Focal Epileptic Networks, 2014

Publisher

ELSEVIER ACADEMIC PRESS INC

Other information

Language

English

Type of outcome

Kapitola resp. kapitoly v odborné knize

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

References:

RIV identification code

RIV/00216224:14740/14:00079992

Organization unit

Central European Institute of Technology

ISBN

978-0-12-418693-4

DOI

UT WoS

000340439500010

Keywords in English

TEMPORAL-LOBE EPILEPSY; POSITRON-EMISSION-TOMOGRAPHY; VOXEL-BASED MORPHOMETRY; GENERALIZED TONICCLONIC SEIZURES

Tags

Tags

International impact, Reviewed
Změněno: 7/4/2015 09:45, Martina Prášilová

Abstract

V originále

A clear concept of epileptic zones remains of high clinical relevance in presurgical evaluation of refractory epilepsy patients and in resection planning. Recent advances in understanding how each of the epileptic zones is functionally organized strengthened the importance of the network concept. It has been shown that neuronal networks underlying the individual epileptic zone may involve multiple brain structures with complex interactions between them. The network concept has impact not only for better understanding of pathophysiology of partial epilepsy but also for clinical practice, particularly for epilepsy surgery. This review examines recent reports on the use of advanced imaging techniques which enable to map the epileptic zones and their structural and functional organization. Magnetic resonance postprocessing substantially improved the accuracy in detection of the epileptogenic lesions. The seizure-onset zone is primarily determined by electrophysiology but can also be localized using single photon emission computed tomography. The functional deficit zone is commonly assessed by a number of tests including methods of functional neuroimaging (positron emission tomography) which can delineate hypometabolic cortical areas and subcortical structures. Hemodynamic fluctuations associated with interictal epileptiform discharges can be detected by novel functional magnetic resonance technique which is nowadays widely used for the irritative zone localization. These techniques open new prospect for epilepsy surgery in patients who were previously considered as not suitable candidates of surgical treatment.