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@proceedings{1297328,
author = {Češka, Milan and Schneider, Caroline and Abate, Alessandro and Šafránek, David and Mahadevan, Louis and Kwiatkowska, Marta},
booktitle = {CMSB 2014},
keywords = {systems biology; probabilistic dynamical systems; RNA transcription; piece-wise deterministic Markov process},
language = {eng},
title = {Stochastic Modelling of the Interface between Regulatory Enzymes and Transcription Initiation at Inducible Genes},
url = {http://www.comp-sys-bio.org/CMSB14/accepted.html},
year = {2014}
}
TY - CONF
ID - 1297328
AU - Češka, Milan - Schneider, Caroline - Abate, Alessandro - Šafránek, David - Mahadevan, Louis - Kwiatkowska, Marta
PY - 2014
TI - Stochastic Modelling of the Interface between Regulatory Enzymes and Transcription Initiation at Inducible Genes
KW - systems biology
KW - probabilistic dynamical systems
KW - RNA transcription
KW - piece-wise deterministic Markov process
UR - http://www.comp-sys-bio.org/CMSB14/accepted.html
L2 - http://www.comp-sys-bio.org/CMSB14/accepted.html
N2 - Inducible genes controlled by signalling cascades may be regulated as continuously variable or as two-state on/off switche. We describe a novel stochastic model of the interface between signal transduction and transcription initiation that accommodates both possibilities. The main challenge has been the need to reconcile the dynamics of a single copy of each gene interacting with a large population of signalling molecules. Comparison of measurements of mRNA levels in live cells with the outputs of the model allows us to test its conformance with experimental data. Our approach dissects the characteristics of the interface, an essential mechanism driving the initiation as well as the production of mRNA. The model provides a range of predictions for initiation and mRNA profiles as a function of the interface parameters, and may now be more closely aligned with further experimental observations.
ER -
ČEŠKA, Milan, Caroline SCHNEIDER, Alessandro ABATE, David ŠAFRÁNEK, Louis MAHADEVAN a Marta KWIATKOWSKA. Stochastic Modelling of the Interface between Regulatory Enzymes and Transcription Initiation at Inducible Genes. In \textit{CMSB 2014}. 2014.
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