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@article{1297350,
author = {Veselá, Pavla and Tonar, Zbyněk and Šálek, David and Vokurka, Samuel and Trněný, Marek and Kodet, Roman and Moulis, Mojmír and Kašparová, Petra and Vernerová, Zdeňka and Velenská, Zuzana and Stříteský, Jan and Michal, Michal and Boudová, Ludmila},
article_location = {New York},
article_number = {5},
doi = {http://dx.doi.org/10.1007/s00428-014-1632-4},
keywords = {Angiogenesis; Mantle cell lymphoma; Mantle cell lymphoma international prognostic index; Microvessel density; Prognosis; Proliferative activity},
language = {eng},
issn = {0945-6317},
journal = {Virchows Archiv},
title = {Microvessel density of mantle cell lymphoma. A retrospective study of its prognostic role and the correlation with the Ki-67 and the mantle cell lymphoma international prognostic index in 177 cases},
volume = {465},
year = {2014}
}
TY - JOUR
ID - 1297350
AU - Veselá, Pavla - Tonar, Zbyněk - Šálek, David - Vokurka, Samuel - Trněný, Marek - Kodet, Roman - Moulis, Mojmír - Kašparová, Petra - Vernerová, Zdeňka - Velenská, Zuzana - Stříteský, Jan - Michal, Michal - Boudová, Ludmila
PY - 2014
TI - Microvessel density of mantle cell lymphoma. A retrospective study of its prognostic role and the correlation with the Ki-67 and the mantle cell lymphoma international prognostic index in 177 cases
JF - Virchows Archiv
VL - 465
IS - 5
SP - 587-597
EP - 587-597
PB - Springer
SN - 09456317
KW - Angiogenesis
KW - Mantle cell lymphoma
KW - Mantle cell lymphoma international prognostic index
KW - Microvessel density
KW - Prognosis
KW - Proliferative activity
N2 - The clinical course and therapy of mantle cell lymphoma (MCL) are heterogeneous and often unsatisfactory. Prognostic factors are needed to stratify the patients. Microvessel density (MVD) has prognostic significance in some malignancies. There is little information about the vasculature of MCL, although some antiangiogenic drugs are in use. We studied MVD using systematic uniform random sampling and unbiased counting frames in immunohistochemical reactions with anti-CD34 antibody in pre-therapeutic extramedullary MCL samples of 177 patients. We analyzed the relationship of MVD to overall survival (OS) and progression-free survival (PFS), as well as to proliferative activity (Ki-67), mantle cell lymphoma prognostic index (MIPI), morphological variant, pattern of growth, and localization. MVD varied widely: range 54.6-503.6 vessels/mm(2), median 158.2 vessels/mm(2). Higher MVD was associated with bone marrow infiltration at the time of diagnosis (P = 0.001). High MVD was associated with significantly worse OS (P = 0.04) only in patients treated with non-intensive (conventional) therapy. MVD correlated positively with MIPI scores but not with the proliferation, morphological variant, growth pattern, or localization. Univariate analysis identified a prognostic influence of morphological variant, MIPI, and proliferative activity on OS and PFS and a prognostic influence of bone marrow infiltration at the time of diagnosis on PFS. Multivariate analysis showed prognostic influence of MIPI and proliferative activity on OS and PFS only. In conclusion, this is the first clinicopathological study of MVD of MCL with long-term follow-up showing negative prognostic trends of high MVD in MCL and positive correlation of MVD and MIPI.
ER -
VESELÁ, Pavla, Zbyněk TONAR, David ŠÁLEK, Samuel VOKURKA, Marek TRNĚNÝ, Roman KODET, Mojmír MOULIS, Petra KAŠPAROVÁ, Zdeňka VERNEROVÁ, Zuzana VELENSKÁ, Jan STŘÍTESKÝ, Michal MICHAL a Ludmila BOUDOVÁ. Microvessel density of mantle cell lymphoma. A retrospective study of its prognostic role and the correlation with the Ki-67 and the mantle cell lymphoma international prognostic index in 177 cases. \textit{Virchows Archiv}. New York: Springer, 2014, roč.~465, č.~5, s.~587-597. ISSN~0945-6317. Dostupné z: https://dx.doi.org/10.1007/s00428-014-1632-4.
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