Antagonism of Adenosine A1 or A2A Receptors Amplifies the
Effects of MDMA on Glial Activation in the Mouse Brain:
Relevance to Caffeine–MDMA Interactions

J 2014

Antagonism of Adenosine A1 or A2A Receptors Amplifies the Effects of MDMA on Glial Activation in the Mouse Brain: Relevance to Caffeine–MDMA Interactions

KHAIRNAR, Amit Suresh, Lucia FRAU, Antonio PLUMITALLO, Micaela MORELLI, Nicola SIMOLA et. al.

Základní údaje

Originální název

Antagonism of Adenosine A1 or A2A Receptors Amplifies the Effects of MDMA on Glial Activation in the Mouse Brain: Relevance to Caffeine–MDMA Interactions

Autoři

KHAIRNAR, Amit Suresh (356 Indie, garant, domácí), Lucia FRAU (380 Itálie), Antonio PLUMITALLO (380 Itálie), Micaela MORELLI (380 Itálie) a Nicola SIMOLA (380 Itálie)

Vydání

Journal of Caffeine Research, 2014, 2156-5783

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14740/14:00080044

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1089/jcr.2014.0006

Klíčová slova anglicky

the Effects of MDMA; Antagonism of Adenosine A1 or A2A;

Štítky

kontrola MP, MP, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 4. 2015 14:29, Martina Prášilová

Anotace

V originále

3,4-Methylendioxymethamphetamine (MDMA, ‘‘ecstasy’’) is a recreational drug very popular in settings such as dance parties and raves.1 MDMA is usually sold on the illegal market as tablets which, besides the drug itself, often contain several impurities, including other psychoactive substances.2 Caffeine is one of the most common of these contaminants,3–5 and this suggests that the unintentional combined consumption of caffeine and MDMA is very likely in people who take this amphetamine-related drug. In addition, the habit of consuming caffeinated beverages together with psychostimulants, to attenuate the endof- dose side effects of these drugs, has increased since the introduction of the so-called energy drinks. Because of this, the possible pharmacological interactions between MDMA and caffeine deserve full consideration. In fact, even though the harmful effects of caffeine itself are narrowed to selected categories of individuals,6 this substance can become dangerous when taken together with MDMA, as clearly demonstrated by previous studies showing that caffeine profoundly increases both the hyperthermia and tachycardia elicited by this amphetamine-related drug

Návaznosti

EE2.3.30.0009, projekt VaV

Název: Zaměstnáním čerstvých absolventů doktorského studia k vědecké excelenci

Citovat

KHAIRNAR, Amit Suresh, Lucia FRAU, Antonio PLUMITALLO, Micaela MORELLI a Nicola SIMOLA. Antagonism of Adenosine A1 or A2A Receptors Amplifies the Effects of MDMA on Glial Activation in the Mouse Brain: Relevance to Caffeine–MDMA Interactions. Journal of Caffeine Research. 2014, roč. 4, č. 2, s. 41-47. ISSN 2156-5783. Dostupné z: https://dx.doi.org/10.1089/jcr.2014.0006.

@article{1297437,
   author = {Khairnar, Amit Suresh and Frau, Lucia and Plumitallo, Antonio and Morelli, Micaela and Simola, Nicola},
   article_number = {2},
   doi = {http://dx.doi.org/10.1089/jcr.2014.0006},
   keywords = {the Effects of MDMA; Antagonism of Adenosine A1 or A2A;},
   language = {eng},
   issn = {2156-5783},
   journal = {Journal of Caffeine Research},
   title = {Antagonism of Adenosine A1 or A2A Receptors Amplifies the Effects of MDMA on Glial Activation in the Mouse Brain: Relevance to Caffeine–MDMA Interactions},
   url = {http://online.liebertpub.com/doi/pdfplus/10.1089/jcr.2014.0006},
   volume = {4},
   year = {2014}
}

TY  - JOUR
ID  - 1297437
AU  - Khairnar, Amit Suresh - Frau, Lucia - Plumitallo, Antonio - Morelli, Micaela - Simola, Nicola
PY  - 2014
TI  - Antagonism of Adenosine A1 or A2A Receptors Amplifies the Effects of MDMA on Glial Activation in the Mouse Brain: Relevance to Caffeine–MDMA Interactions
JF  - Journal of Caffeine Research
VL  - 4
IS  - 2
SP  - 41-47
EP  - 41-47
SN  - 21565783
KW  - the Effects of MDMA
KW  - Antagonism of Adenosine A1 or A2A;
UR  - http://online.liebertpub.com/doi/pdfplus/10.1089/jcr.2014.0006
L2  - http://online.liebertpub.com/doi/pdfplus/10.1089/jcr.2014.0006
N2  - 3,4-Methylendioxymethamphetamine (MDMA, ‘‘ecstasy’’) is a recreational drug very popular in settings such as dance parties and raves.1 MDMA is usually sold on the illegal market as tablets which, besides the drug itself, often contain several impurities, including other psychoactive substances.2 Caffeine is one of the most common of these contaminants,3–5 and this suggests that the unintentional combined consumption of caffeine and MDMA is very likely in people who take this amphetamine-related drug. In addition, the habit of consuming caffeinated beverages together with psychostimulants, to attenuate the endof- dose side effects of these drugs, has increased since the introduction of the so-called energy drinks. Because of this, the possible pharmacological interactions between MDMA and caffeine deserve full consideration. In fact, even though the harmful effects of caffeine itself are narrowed to selected categories of individuals,6 this substance can become dangerous when taken together with MDMA, as clearly demonstrated by previous studies showing that caffeine profoundly increases both the hyperthermia and tachycardia elicited by this amphetamine-related drug
ER  -

KHAIRNAR, Amit Suresh, Lucia FRAU, Antonio PLUMITALLO, Micaela MORELLI a Nicola SIMOLA. Antagonism of Adenosine A1 or A2A Receptors Amplifies the Effects of MDMA on Glial Activation in the Mouse Brain: Relevance to Caffeine–MDMA Interactions. \textit{Journal of Caffeine Research}. 2014, roč.~4, č.~2, s.~41-47. ISSN~2156-5783. Dostupné z: https://dx.doi.org/10.1089/jcr.2014.0006.

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