Antagonism of Adenosine A1 or A2A Receptors Amplifies the
Effects of MDMA on Glial Activation in the Mouse Brain:
Relevance to Caffeine–MDMA Interactions

J 2014

Antagonism of Adenosine A1 or A2A Receptors Amplifies the Effects of MDMA on Glial Activation in the Mouse Brain: Relevance to Caffeine–MDMA Interactions

KHAIRNAR, Amit Suresh, Lucia FRAU, Antonio PLUMITALLO, Micaela MORELLI, Nicola SIMOLA et. al.

Basic information

Original name

Antagonism of Adenosine A1 or A2A Receptors Amplifies the Effects of MDMA on Glial Activation in the Mouse Brain: Relevance to Caffeine–MDMA Interactions

Authors

KHAIRNAR, Amit Suresh (356 India, guarantor, belonging to the institution), Lucia FRAU (380 Italy), Antonio PLUMITALLO (380 Italy), Micaela MORELLI (380 Italy) and Nicola SIMOLA (380 Italy)

Edition

Journal of Caffeine Research, 2014, 2156-5783

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14740/14:00080044

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1089/jcr.2014.0006

Keywords in English

the Effects of MDMA; Antagonism of Adenosine A1 or A2A;

Abstract

V originále

3,4-Methylendioxymethamphetamine (MDMA, ‘‘ecstasy’’) is a recreational drug very popular in settings such as dance parties and raves.1 MDMA is usually sold on the illegal market as tablets which, besides the drug itself, often contain several impurities, including other psychoactive substances.2 Caffeine is one of the most common of these contaminants,3–5 and this suggests that the unintentional combined consumption of caffeine and MDMA is very likely in people who take this amphetamine-related drug. In addition, the habit of consuming caffeinated beverages together with psychostimulants, to attenuate the endof- dose side effects of these drugs, has increased since the introduction of the so-called energy drinks. Because of this, the possible pharmacological interactions between MDMA and caffeine deserve full consideration. In fact, even though the harmful effects of caffeine itself are narrowed to selected categories of individuals,6 this substance can become dangerous when taken together with MDMA, as clearly demonstrated by previous studies showing that caffeine profoundly increases both the hyperthermia and tachycardia elicited by this amphetamine-related drug

Links

EE2.3.30.0009, research and development project

Name: Zaměstnáním čerstvých absolventů doktorského studia k vědecké excelenci

Citovat

KHAIRNAR, Amit Suresh, Lucia FRAU, Antonio PLUMITALLO, Micaela MORELLI and Nicola SIMOLA. Antagonism of Adenosine A1 or A2A Receptors Amplifies the Effects of MDMA on Glial Activation in the Mouse Brain: Relevance to Caffeine–MDMA Interactions. Journal of Caffeine Research. 2014, vol. 4, No 2, p. 41-47. ISSN 2156-5783. Available from: https://dx.doi.org/10.1089/jcr.2014.0006.

@article{1297437,
   author = {Khairnar, Amit Suresh and Frau, Lucia and Plumitallo, Antonio and Morelli, Micaela and Simola, Nicola},
   article_number = {2},
   doi = {http://dx.doi.org/10.1089/jcr.2014.0006},
   keywords = {the Effects of MDMA; Antagonism of Adenosine A1 or A2A;},
   language = {eng},
   issn = {2156-5783},
   journal = {Journal of Caffeine Research},
   title = {Antagonism of Adenosine A1 or A2A Receptors Amplifies the Effects of MDMA on Glial Activation in the Mouse Brain: Relevance to Caffeine–MDMA Interactions},
   url = {http://online.liebertpub.com/doi/pdfplus/10.1089/jcr.2014.0006},
   volume = {4},
   year = {2014}
}

TY  - JOUR
ID  - 1297437
AU  - Khairnar, Amit Suresh - Frau, Lucia - Plumitallo, Antonio - Morelli, Micaela - Simola, Nicola
PY  - 2014
TI  - Antagonism of Adenosine A1 or A2A Receptors Amplifies the Effects of MDMA on Glial Activation in the Mouse Brain: Relevance to Caffeine–MDMA Interactions
JF  - Journal of Caffeine Research
VL  - 4
IS  - 2
SP  - 41-47
EP  - 41-47
SN  - 21565783
KW  - the Effects of MDMA
KW  - Antagonism of Adenosine A1 or A2A;
UR  - http://online.liebertpub.com/doi/pdfplus/10.1089/jcr.2014.0006
L2  - http://online.liebertpub.com/doi/pdfplus/10.1089/jcr.2014.0006
N2  - 3,4-Methylendioxymethamphetamine (MDMA, ‘‘ecstasy’’) is a recreational drug very popular in settings such as dance parties and raves.1 MDMA is usually sold on the illegal market as tablets which, besides the drug itself, often contain several impurities, including other psychoactive substances.2 Caffeine is one of the most common of these contaminants,3–5 and this suggests that the unintentional combined consumption of caffeine and MDMA is very likely in people who take this amphetamine-related drug. In addition, the habit of consuming caffeinated beverages together with psychostimulants, to attenuate the endof- dose side effects of these drugs, has increased since the introduction of the so-called energy drinks. Because of this, the possible pharmacological interactions between MDMA and caffeine deserve full consideration. In fact, even though the harmful effects of caffeine itself are narrowed to selected categories of individuals,6 this substance can become dangerous when taken together with MDMA, as clearly demonstrated by previous studies showing that caffeine profoundly increases both the hyperthermia and tachycardia elicited by this amphetamine-related drug
ER  -

KHAIRNAR, Amit Suresh, Lucia FRAU, Antonio PLUMITALLO, Micaela MORELLI and Nicola SIMOLA. Antagonism of Adenosine A1 or A2A Receptors Amplifies the Effects of MDMA on Glial Activation in the Mouse Brain: Relevance to Caffeine–MDMA Interactions. \textit{Journal of Caffeine Research}. 2014, vol.~4, No~2, p.~41-47. ISSN~2156-5783. Available from: https://dx.doi.org/10.1089/jcr.2014.0006.

Detailed Information on Publication Record