| MENSIKOVA, K., P. KANOVSKY, P. OTRUBA, M. KAISEROVA, M. VASTIK, P. HLUSTIK, L. MIKULICOVA, T. BARTONIKOVA, P. DUDOVA, P. JUGAS, J. OVECKA, L. SACHOVA, F. DVORSKY, J. KRSA, M. GODAVA, R. VODICKA, R. VRTEL, Martin BAREŠ and V. JANOUT. Epidemiological Study of Neurodegenerative Parkinsonism in "Hornacko", a Specific Region of the South-eastern Moravia, Czech Republic. Česká a Slovenska neurologie a neurochirurgie. Praha: Česká lékařská společnost J.E. Purkyně, 2014, vol. 77, No 6, p. 714-720. ISSN 1210-7859. Available from: https://dx.doi.org/10.14735/amcsnn2014714. |
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@article{1297761,
author = {Mensikova, K. and Kanovsky, P. and Otruba, P. and Kaiserova, M. and Vastik, M. and Hlustik, P. and Mikulicova, L. and Bartonikova, T. and Dudova, P. and Jugas, P. and Ovecka, J. and Sachova, L. and Dvorsky, F. and Krsa, J. and Godava, M. and Vodicka, R. and Vrtel, R. and Bareš, Martin and Janout, V.},
article_location = {Praha},
article_number = {6},
doi = {http://dx.doi.org/10.14735/amcsnn2014714},
keywords = {parkinsonism; neuroepidemiology; prevalence study; three-stage ascertainment method; inheritance},
language = {eng},
issn = {1210-7859},
journal = {Česká a Slovenska neurologie a neurochirurgie},
title = {Epidemiological Study of Neurodegenerative Parkinsonism in "Hornacko", a Specific Region of the South-eastern Moravia, Czech Republic},
volume = {77},
year = {2014}
}
TY - JOUR
ID - 1297761
AU - Mensikova, K. - Kanovsky, P. - Otruba, P. - Kaiserova, M. - Vastik, M. - Hlustik, P. - Mikulicova, L. - Bartonikova, T. - Dudova, P. - Jugas, P. - Ovecka, J. - Sachova, L. - Dvorsky, F. - Krsa, J. - Godava, M. - Vodicka, R. - Vrtel, R. - Bareš, Martin - Janout, V.
PY - 2014
TI - Epidemiological Study of Neurodegenerative Parkinsonism in "Hornacko", a Specific Region of the South-eastern Moravia, Czech Republic
JF - Česká a Slovenska neurologie a neurochirurgie
VL - 77
IS - 6
SP - 714-720
EP - 714-720
PB - Česká lékařská společnost J.E. Purkyně
SN - 12107859
KW - parkinsonism
KW - neuroepidemiology
KW - prevalence study
KW - three-stage ascertainment method
KW - inheritance
N2 - Introduction: It has been suggested that the prevalence of neurodegenerative diseases in small, isolated European communities might be higher than in the general population. We recently observed this phenomenon in a small specific region of south-eastern Moravia. Objective: To assess the prevalence of neurodegenerative parkinsonism in an isolated region with a rural population in south-eastern Moravia. Methods: A three-stage method of data collection was used. In the first phase, originally designed questionnaires were distributed to general practitioners and completed by all patients who visited them for any reason during a three-month period. In the second phase, positive responders were examined by trained primary care neurologists. Finally, the diagnosis was confirmed or excluded by a movement disorders specialist. Results: The overall prevalence in the population older than 50 years of age was 2.8% (95% CI: 2.2-3.4); the prevalence in the population from 50 to 64 years was 1.9% (95% CI: 1.2-2.5), and it was 4.06% (95% CI: 2.9-5.1) in the population over 65 years of age. Three large families with an autosomal-dominant inheritance patterns of parkinsonism were identified. Conclusions: The prevalence rates were surprisingly high; they substantially differed from the published prevalence rates in other European countries. Due to the characteristics of the region, we expected a particular impact of genetic factors, most probably the autosomal-dominant inheritance of parkinsonism. Our current research focusses on the genetic background and DNA analysis of probands from the families in which autosomal-dominant parkinsonism was identified.
ER -
MENSIKOVA, K., P. KANOVSKY, P. OTRUBA, M. KAISEROVA, M. VASTIK, P. HLUSTIK, L. MIKULICOVA, T. BARTONIKOVA, P. DUDOVA, P. JUGAS, J. OVECKA, L. SACHOVA, F. DVORSKY, J. KRSA, M. GODAVA, R. VODICKA, R. VRTEL, Martin BAREŠ and V. JANOUT. Epidemiological Study of Neurodegenerative Parkinsonism in ''Hornacko'', a Specific Region of the South-eastern Moravia, Czech Republic. \textit{Česká a Slovenska neurologie a neurochirurgie}. Praha: Česká lékařská společnost J.E. Purkyně, 2014, vol.~77, No~6, p.~714-720. ISSN~1210-7859. Available from: https://dx.doi.org/10.14735/amcsnn2014714.
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