VŠIANSKÁ, Pavla, Lucie ŘÍHOVÁ, Tamara VARMUŽOVÁ, Renata SUSKÁ, Fedor KRYUKOV, Aneta MIKULÁŠOVÁ, Renata KUPSKÁ, Miroslav PENKA, Luděk POUR, Zdeněk ADAM and Roman HÁJEK. Analysis of B-Cell Subpopulations in Monoclonal Gammopathies. Clinical Lymphoma Myeloma & Leukemia. Dallas: CIG MEDIA GROUP, 2015, vol. 15, No 4, p. "e61"-"e71", 11 pp. ISSN 2152-2650. Available from: https://dx.doi.org/10.1016/j.clml.2014.12.003.
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Basic information
Original name Analysis of B-Cell Subpopulations in Monoclonal Gammopathies
Authors VŠIANSKÁ, Pavla (203 Czech Republic, guarantor, belonging to the institution), Lucie ŘÍHOVÁ (203 Czech Republic, belonging to the institution), Tamara VARMUŽOVÁ (203 Czech Republic, belonging to the institution), Renata SUSKÁ (203 Czech Republic), Fedor KRYUKOV (643 Russian Federation, belonging to the institution), Aneta MIKULÁŠOVÁ (203 Czech Republic, belonging to the institution), Renata KUPSKÁ (203 Czech Republic, belonging to the institution), Miroslav PENKA (203 Czech Republic), Luděk POUR (203 Czech Republic), Zdeněk ADAM (203 Czech Republic, belonging to the institution) and Roman HÁJEK (203 Czech Republic, belonging to the institution).
Edition Clinical Lymphoma Myeloma & Leukemia, Dallas, CIG MEDIA GROUP, 2015, 2152-2650.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.316
RIV identification code RIV/00216224:14110/15:00080785
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.clml.2014.12.003
Keywords in English B-cell; Flow Cytometry; Multiple Myeloma; Monoclonal Gammopathy; Plasma Cell
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 6/5/2015 11:01.
Abstract
To clarify the pathophysiology of multiple myeloma (MM) it is necessary to investigate the various developmental stages of B-cells. We provide a detailed phenotypic profile and enumeration of B-cell subpopulations in monoclonal gammopathy patients. A reduction of B-cells and differentiation shift to more numerous antigenstimulated forms was observed in MM. This might indicate a potential source of myeloma-initiating cells in one of these subpopulations.
Links
GAP304/10/1395, research and development projectName: Analýza klonálních progenitorů plazmatických buněk u monoklonálních gamapatií
Investor: Czech Science Foundation
MSM0021622434, plan (intention)Name: Od klasických prognostických markerů ke klinicky aplikovatelným farmakogenomickým a farmakoproteomickým projektům u mnohočetného myelomu a monoklonálních gamapatií
Investor: Ministry of Education, Youth and Sports of the CR, From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
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