| METZGER, M.L., I. MICHELFELDER, S. GOLDACKER, K. MELKAOUI, Jiří LITZMAN, D. GUZMAN, B. GRIMBACHER a U. SALZER. Low ficolin-2 levels in common variable immunodeficiency patients with bronchiectasis. Clinical and Experimental Immunology. Hoboken: Blackwell Publishing, 2015, roč. 179, č. 2, s. 256-264. ISSN 0009-9104. Dostupné z: https://dx.doi.org/10.1111/cei.12459. |
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@article{1299558,
author = {Metzger, M.L. and Michelfelder, I. and Goldacker, S. and Melkaoui, K. and Litzman, Jiří and Guzman, D. and Grimbacher, B. and Salzer, U.},
article_location = {Hoboken},
article_number = {2},
doi = {http://dx.doi.org/10.1111/cei.12459},
keywords = {complement; CVID; ficolin-2; ficolin-3; lectin pathway},
language = {eng},
issn = {0009-9104},
journal = {Clinical and Experimental Immunology},
title = {Low ficolin-2 levels in common variable immunodeficiency patients with bronchiectasis},
volume = {179},
year = {2015}
}
TY - JOUR
ID - 1299558
AU - Metzger, M.L. - Michelfelder, I. - Goldacker, S. - Melkaoui, K. - Litzman, Jiří - Guzman, D. - Grimbacher, B. - Salzer, U.
PY - 2015
TI - Low ficolin-2 levels in common variable immunodeficiency patients with bronchiectasis
JF - Clinical and Experimental Immunology
VL - 179
IS - 2
SP - 256-264
EP - 256-264
PB - Blackwell Publishing
SN - 00099104
KW - complement
KW - CVID
KW - ficolin-2
KW - ficolin-3
KW - lectin pathway
N2 - Common variable immunodeficiency (CVID) encompasses a heterogeneous group of antibody deficiencies characterized by susceptibility to recurrent infections and sequelae, including bronchiectasis. We investigated the relevance of the lectin complement pathway in CVID patients by analysing ficolin-2 and ficolin-3 serum levels and genotyping single nucleotide polymorphisms (SNPs) in the FCN2 and FCN3 genes. Our results show that ficolin-2 levels in CVID patients are significantly lower (P<00001) than in controls. The lowest ficolin-2 levels are found in CVID patients with bronchiectasis (P=00004) and autoimmunity (P=004). Although serum levels of ficolin-3 were similar in CVID patients and controls, CVID patients with bronchiectasis again showed lower levels when compared to controls (P=00001). Analysis of single nucleotide polymorphisms in the FCN2 gene confirmed known influences on ficolin-2 serum levels, but did not support a genetic basis for the observed ficolin-2 deficiency in CVID. We found that CVID patients with bronchiectasis have very low levels of ficolin-2. The reason for the deficiency of ficolin-2 in CVID and any possible causal relationship is currently unknown. However, as bronchiectasis is a very important factor for morbidity and mortality in CVID, ficolin-2 could also serve as biomarker for monitoring disease complications such as bronchiectasis.
ER -
METZGER, M.L., I. MICHELFELDER, S. GOLDACKER, K. MELKAOUI, Jiří LITZMAN, D. GUZMAN, B. GRIMBACHER a U. SALZER. Low ficolin-2 levels in common variable immunodeficiency patients with bronchiectasis. \textit{Clinical and Experimental Immunology}. Hoboken: Blackwell Publishing, 2015, roč.~179, č.~2, s.~256-264. ISSN~0009-9104. Dostupné z: https://dx.doi.org/10.1111/cei.12459.
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