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@inproceedings{1300364,
author = {Večeřová, Aneta and Hudcová, Kristýna and Pilařová, Iveta and Masařík, Michal and Trnková, Libuše},
address = {Ústí nad Labem},
booktitle = {XXXV. Moderní elektrochemické metody},
edition = {1},
editor = {Tomáš Navrátil, Miroslav Fojta, Karolína Schwarzová},
keywords = {miR-34a-5p; human cancer; miDNA; cyclic voltammetry; linear sweep voltammetry; circular dichroic spectroscopy; mercury electrode},
howpublished = {tištěná verze "print"},
language = {eng},
location = {Ústí nad Labem},
isbn = {978-80-905221-3-8},
note = {Opraven obor publikace},
pages = {265-268},
publisher = {Srsenová Lenka - Best servis Ústí nad Labem},
title = {Electrochemical and Spectral Behavior of MicroRNA (miR-34a-5p)},
year = {2015}
}
TY - JOUR
ID - 1300364
AU - Večeřová, Aneta - Hudcová, Kristýna - Pilařová, Iveta - Masařík, Michal - Trnková, Libuše
PY - 2015
TI - Electrochemical and Spectral Behavior of MicroRNA (miR-34a-5p)
PB - Srsenová Lenka - Best servis Ústí nad Labem
CY - Ústí nad Labem
SN - 9788090522138
N1 - Opraven obor publikace
KW - miR-34a-5p
KW - human cancer
KW - miDNA
KW - cyclic voltammetry
KW - linear sweep voltammetry
KW - circular dichroic spectroscopy
KW - mercury electrode
N2 - MicroRNAs are a family of small noncoding RNAs (21-25 nucleotides), negatively regulating gene expresion at the post-transcriptional level. Their functions are critical to normal cellular processes such as differentiation and apoptosis. recent studies demonstrated that deregulated miRNA expression contributes to the malignant phenotype and for this reason miRNAs play a key role as both diagnostic markers and therapeutic targets for many different tumor types (colorectal cancer, breast cancer, lung cancer, prostate cancer, etc.). Great attention is devoted to the study of miR-34a-5p related to head and neck cancer and also prostate cancer. This miRNA is a direct transcriptional target of p53 and its overexpression after p53 activation mediates some of the key tumor suppressive effects of p53 via induction of growth arrest, apoptisis or senescence. Our contribution is focused on the comparison of the structure of miRNA, based on ribose, and its miDNA analogues, based on deoxyribose and containing U or T in this sequence, by using voltammetric methods (cyclic voltammetry - CV or linear sweep voltammetry - LSV). The voltammetric experiment was completed with CD (circular dichroism) spectra.
ER -
VEČEŘOVÁ, Aneta, Kristýna HUDCOVÁ, Iveta PILAŘOVÁ, Michal MASAŘÍK and Libuše TRNKOVÁ. Electrochemical and Spectral Behavior of MicroRNA (miR-34a-5p). In Tomáš Navrátil, Miroslav Fojta, Karolína Schwarzová. \textit{XXXV. Moderní elektrochemické metody}. 1st ed. Ústí nad Labem: Srsenová Lenka - Best servis Ústí nad Labem, 2015, p.~265-268. ISBN~978-80-905221-3-8.
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