Physical Exercise Keeps the Brain Connected: Biking Increases
White Matter Integrity in Patients With Schizophrenia and
Healthy Controls

J 2015

Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls

SVÁTKOVÁ, Alena, Rene C. W. MANDL, Thomas W. SCHEEWE, Wiepke CAHN, Rene S. KAHN et. al.

Základní údaje

Originální název

Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls

Autoři

SVÁTKOVÁ, Alena (703 Slovensko, garant, domácí), Rene C. W. MANDL (528 Nizozemské království), Thomas W. SCHEEWE (528 Nizozemské království), Wiepke CAHN (528 Nizozemské království), Rene S. KAHN (528 Nizozemské království) a Hilleke E. HULSHOFF POL (528 Nizozemské království)

Vydání

Schizophrenia Bulletin, Oxford, Oxford University Press, 2015, 0586-7614

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.757

Kód RIV

RIV/00216224:14740/15:00083091

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1093/schbul/sbv033

UT WoS

000357891500014

Klíčová slova anglicky

connectivity; diffusion tensor imaging; fractional anisotropy; longitudinal; physical exercise; schizophrenia

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 3. 2016 10:49, Mgr. Eva Špillingová

Anotace

V originále

It has been shown that learning a new skill leads to structural changes in the brain. However, it is unclear whether it is the acquisition or continuous practicing of the skill that causes this effect and whether brain connectivity of patients with schizophrenia can benefit from such practice. We examined the effect of 6 months exercise on a stationary bicycle on the brain in patients with schizophrenia and healthy controls. Biking is an endemic skill in the Netherlands and thus offers an ideal situation to disentangle the effects of learning vs practice. The 33 participating patients with schizophrenia and 48 healthy individuals were assigned to either one of two conditions, ie, physical exercise or life-as-usual, balanced for diagnosis. Diffusion tensor imaging brain scans were made prior to and after intervention. We demonstrate that irrespective of diagnosis regular physical exercise of an overlearned skill, such as bicycling, significantly increases the integrity, especially of motor functioning related, white matter fiber tracts whereas life-as-usual leads to a decrease in fiber integrity. Our findings imply that exercise of an overlearned physical skill improves brain connectivity in patients and healthy individuals. This has important implications for understanding the effect of fitness programs on the brain in both healthy subjects and patients with schizophrenia. Moreover, the outcome may even apply to the nonphysical realm.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

SVÁTKOVÁ, Alena, Rene C. W. MANDL, Thomas W. SCHEEWE, Wiepke CAHN, Rene S. KAHN a Hilleke E. HULSHOFF POL. Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls. Schizophrenia Bulletin. Oxford: Oxford University Press, 2015, roč. 41, č. 4, s. 869-878. ISSN 0586-7614. Dostupné z: https://dx.doi.org/10.1093/schbul/sbv033.

@article{1300721,
   author = {Svátková, Alena and Mandl, Rene C. W. and Scheewe, Thomas W. and Cahn, Wiepke and Kahn, Rene S. and Hulshoff Pol, Hilleke E.},
   article_location = {Oxford},
   article_number = {4},
   doi = {http://dx.doi.org/10.1093/schbul/sbv033},
   keywords = {connectivity; diffusion tensor imaging; fractional anisotropy; longitudinal; physical exercise; schizophrenia},
   language = {eng},
   issn = {0586-7614},
   journal = {Schizophrenia Bulletin},
   title = {Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls},
   url = {http://schizophreniabulletin.oxfordjournals.org/content/early/2015/03/30/schbul.sbv033.abstract},
   volume = {41},
   year = {2015}
}

TY  - JOUR
ID  - 1300721
AU  - Svátková, Alena - Mandl, Rene C. W. - Scheewe, Thomas W. - Cahn, Wiepke - Kahn, Rene S. - Hulshoff Pol, Hilleke E.
PY  - 2015
TI  - Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls
JF  - Schizophrenia Bulletin
VL  - 41
IS  - 4
SP  - 869-878
EP  - 869-878
PB  - Oxford University Press
SN  - 05867614
KW  - connectivity
KW  - diffusion tensor imaging
KW  - fractional anisotropy
KW  - longitudinal
KW  - physical exercise
KW  - schizophrenia
UR  - http://schizophreniabulletin.oxfordjournals.org/content/early/2015/03/30/schbul.sbv033.abstract
L2  - http://schizophreniabulletin.oxfordjournals.org/content/early/2015/03/30/schbul.sbv033.abstract
N2  - It has been shown that learning a new skill leads to structural changes in the brain. However, it is unclear whether it is the acquisition or continuous practicing of the skill that causes this effect and whether brain connectivity of patients with schizophrenia can benefit from such practice. We examined the effect of 6 months exercise on a stationary bicycle on the brain in patients with schizophrenia and healthy controls. Biking is an endemic skill in the Netherlands and thus offers an ideal situation to disentangle the effects of learning vs practice. The 33 participating patients with schizophrenia and 48 healthy individuals were assigned to either one of two conditions, ie, physical exercise or life-as-usual, balanced for diagnosis. Diffusion tensor imaging brain scans were made prior to and after intervention. We demonstrate that irrespective of diagnosis regular physical exercise of an overlearned skill, such as bicycling, significantly increases the integrity, especially of motor functioning related, white matter fiber tracts whereas life-as-usual leads to a decrease in fiber integrity. Our findings imply that exercise of an overlearned physical skill improves brain connectivity in patients and healthy individuals. This has important implications for understanding the effect of fitness programs on the brain in both healthy subjects and patients with schizophrenia. Moreover, the outcome may even apply to the nonphysical realm.
ER  -

SVÁTKOVÁ, Alena, Rene C. W. MANDL, Thomas W. SCHEEWE, Wiepke CAHN, Rene S. KAHN a Hilleke E. HULSHOFF POL. Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls. \textit{Schizophrenia Bulletin}. Oxford: Oxford University Press, 2015, roč.~41, č.~4, s.~869-878. ISSN~0586-7614. Dostupné z: https://dx.doi.org/10.1093/schbul/sbv033.

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