2015
Is collagen matrix suitable as a carrier in periodontal regeneration?
VOKURKA, Jan, Eva BUCHALOVÁ, Lucie POŽÁROVÁ, Marie BLAHUTKOVÁ, Eduard GÖPFERT et. al.Základní údaje
Originální název
Is collagen matrix suitable as a carrier in periodontal regeneration?
Název česky
Je kolagenní membrána vhodným nosičem v parodontální regeneraci?
Autoři
VOKURKA, Jan, Eva BUCHALOVÁ, Lucie POŽÁROVÁ, Marie BLAHUTKOVÁ, Eduard GÖPFERT, Antonín FASSMANN a Lydie IZAKOVIČOVÁ HOLLÁ
Vydání
2015
Další údaje
Jazyk
angličtina
Typ výsledku
Konferenční abstrakt
Obor
30200 3.2 Clinical medicine
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Organizační jednotka
Lékařská fakulta
Klíčová slova česky
parodontitida, kolagenní matrix, regenerace
Klíčová slova anglicky
periodontitis, collagen matrix, regeneration
Změněno: 21. 6. 2015 13:36, MUDr. Jan Vokurka
Anotace
V originále
• Aim The aim of the present study was to investigate the capacity of collagen matrix (CM) as a carrier for different blood derivates to improve the periodontal regeneration. • Material and Methods In the study 28 white New Zealand rabbits were used after approval from the ethical committee. After administration of premedication and general anesthesia, we created circular artificial defects on the buccal mucosa. The CM (Mucograft, Geistlich Pharma AG, Switzerland) was implanted into the defect alone (positive control), together with Platelet-Rich Plasma (CM+PRP), with Platelet-Rich Fibrin (CM+PRF), or was left untreated (negative control). • Results The samples were analyzed at days 1, 7, and 28. Histological, immunohistochemical and molecular analysis were conducted and the capacity of CM as a carrier was evaluated. Light microscope revealed marginal differences among groups in wound reepitelization, neoangiogenesis, granulation tissue and collagen formation, but no differences in the markers of acute or chronic inflammation (Kruskal-Wallis, p0.05). • Conclusion The advantages and disadvantages of CM as a carrier for blood derivates will be discussed. Our findings have not confirmed yet that CM as a carrier for the tested substances would improve wound healing and the outcomes of periodontal surgery therapy. The study was supported by the grant IGA NT14321 and by project MUNI/A/0951/2013.
Návaznosti
MUNI/A/0951/2013, interní kód MU |
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NT14321, projekt VaV |
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