Cortisol level and memory functioning in first episode schizophrenia

HAVELKA, David, Hana PŘIKRYLOVÁ KUČEROVÁ, Radovan PŘIKRYL a Eva ČEŠKOVÁ. Cortisol level and memory functioning in first episode schizophrenia. In Eleventh symposium on catecholamines and other neurotransmitters in stress. 2015.

Základní údaje

• Originální název: Cortisol level and memory functioning in first episode schizophrenia
• Autoři: HAVELKA, David, Hana PŘIKRYLOVÁ KUČEROVÁ, Radovan PŘIKRYL a Eva ČEŠKOVÁ.
• Vydání: Eleventh symposium on catecholamines and other neurotransmitters in stress, 2015.

Další údaje

• Originální jazyk: angličtina
• Typ výsledku: Prezentace na konferencích
• Obor: 50100 5.1 Psychology and cognitive sciences
• Stát vydavatele: Česká republika
• Utajení: není předmětem státního či obchodního tajemství
• Organizační jednotka: Filozofická fakulta
• Klíčová slova anglicky: cortisol level; memory; first episode schizophrenia
• Příznaky: Mezinárodní význam

Anotace

One of the most common findings related to cognition in schizophrenia is dysfunction of episodic and working memory. A number of studies proved that schizophrenia patients exhibit HPA axis function alterations and also tendency to have higher basal cortisol levels in comparison to healthy controls. Although an inverse correlation between cortisol level and memory function has been proved in many diagnoses and in chronic schizophrenia, few studies have focused on the relationship between cortisol level and cognitive impairment in patients with first episode schizophrenia. In the sample of 23 male patients diagnosed with first-episode schizophrenia, hypothalamic-pituitary-adrenal axis activity (basal cortisol levels, post-dexamethasone cortisol levels) were measured before and at the end of acute treatment. Psychopathology was assessed using the positive and negative syndrome scale (PANSS). Memory and executive functions were tested after symptom alleviation using a neurocognitive test battery. It was found that higher basal cortisol levels before treatment are related to impaired performance in memory functions. No correlation was found between memory or executive functions and post-dexamethasone cortisol levels. There were no differences between the group of suppressors and non-suppressors in relation to memory. Results of the study indicate that basal cortisol levels can point out to the risk of memory function deterioration in first episode schizophrenia patients.In other words, the determination of basal cortisol levels may serve to detect potential candidates for specific cognitive intervention.