Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer’s
Disease Impacts on Cognitive Outcomes of Noninvasive Brain
Stimulation

J 2015

Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer’s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation

ANDERKOVÁ, Ľubomíra, Ilona ELIÁŠOVÁ, Radek MAREČEK, Eva JANOUŠOVÁ, Irena REKTOROVÁ et. al.

Základní údaje

Originální název

Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer’s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation

Autoři

ANDERKOVÁ, Ľubomíra (703 Slovensko, domácí), Ilona ELIÁŠOVÁ (203 Česká republika, domácí), Radek MAREČEK (203 Česká republika, domácí), Eva JANOUŠOVÁ (203 Česká republika, domácí) a Irena REKTOROVÁ (203 Česká republika, garant, domácí)

Vydání

JOURNAL OF ALZHEIMERS DISEASE, AMSTERDAM, IOS PRESS, 2015, 1387-2877

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.920

Kód RIV

RIV/00216224:14740/15:00083300

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.3233/JAD-150067

UT WoS

000360931700023

Klíčová slova anglicky

noninvasive brain stimulation; Alzheimer's disease; cognitive functions; brain atrophy; source-based morphometry

Štítky

EL OK, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 3. 2018 13:29, Mgr. et Mgr. Ľubomíra Nováková, Ph.D.

Anotace

V originále

Background: Repetitive transcranial magnetic stimulation (rTMS) is a promising tool to study and modulate brain plasticity. Objective: Our aim was to investigate the effects of rTMS on cognitive functions in patients with mild cognitive impairment and Alzheimer’s disease (MCI/AD) and assess the effect of gray matter (GM) atrophy on stimulation outcomes. Methods: Twenty MCI/AD patients participated in the proof-of-concept controlled study. Each patient received three sessions of 10 Hz rTMS of the right inferior frontal gyrus (IFG), the right superior temporal gyrus (STG), and the vertex (VTX, a control stimulation site) in a randomized order. Cognitive functions were tested prior to and immediately after each session. The GM volumetric data of patients were: 1)compared to healthy controls (HC) using source-based morphometry; 2) correlated with rTMS-induced cognitive improvement. Results: The effect of the stimulated site on the difference in cognitive scores was statistically significant for the Word part of the Stroop test (ST-W, p = 0.012, linear mixed models). As compared to the VTX stimulation, patients significantly improved after both IFG and STG stimulation in this cognitive measure. MCI/AD patients had significant GM atrophy in characteristic brain regions as compared to HC (p = 0.029, Bonferroni corrected). The amount of atrophy correlated with the change in ST-W scores after rTMS of the STG. Conclusion: rTMS enhanced cognitive functions in MCI/AD patients. We demonstrated for the first time that distinct pattern of GM atrophy in MCI/AD diminishes the cognitive effects induced by rTMS of the temporal neocortex.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Přiložené soubory

ZVV_2015_096_1305227_Distinct_Pattern_of_Gray.pdf

Požádat o autorskou verzi souboru

Citovat

ANDERKOVÁ, Ľubomíra, Ilona ELIÁŠOVÁ, Radek MAREČEK, Eva JANOUŠOVÁ a Irena REKTOROVÁ. Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer’s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation. JOURNAL OF ALZHEIMERS DISEASE. AMSTERDAM: IOS PRESS, 2015, roč. 48, č. 1, s. 251-260. ISSN 1387-2877. Dostupné z: https://dx.doi.org/10.3233/JAD-150067.

@article{1305229,
   author = {Anderková, Ľubomíra and Eliášová, Ilona and Mareček, Radek and Janoušová, Eva and Rektorová, Irena},
   article_location = {AMSTERDAM},
   article_number = {1},
   doi = {http://dx.doi.org/10.3233/JAD-150067},
   keywords = {noninvasive brain stimulation; Alzheimer's disease; cognitive functions; brain atrophy; source-based morphometry},
   language = {eng},
   issn = {1387-2877},
   journal = {JOURNAL OF ALZHEIMERS DISEASE},
   title = {Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer’s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation},
   url = {http://content.iospress.com/articles/journal-of-alzheimers-disease/jad150067},
   volume = {48},
   year = {2015}
}

TY  - JOUR
ID  - 1305229
AU  - Anderková, Ľubomíra - Eliášová, Ilona - Mareček, Radek - Janoušová, Eva - Rektorová, Irena
PY  - 2015
TI  - Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer’s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation
JF  - JOURNAL OF ALZHEIMERS DISEASE
VL  - 48
IS  - 1
SP  - 251-260
EP  - 251-260
PB  - IOS PRESS
SN  - 13872877
KW  - noninvasive brain stimulation
KW  - Alzheimer's disease
KW  - cognitive functions
KW  - brain atrophy
KW  - source-based morphometry
UR  - http://content.iospress.com/articles/journal-of-alzheimers-disease/jad150067
L2  - http://content.iospress.com/articles/journal-of-alzheimers-disease/jad150067
N2  - Background: Repetitive transcranial magnetic stimulation (rTMS) is a promising tool to study and modulate brain plasticity. Objective: Our aim was to investigate the effects of rTMS on cognitive functions in patients with mild cognitive impairment and Alzheimer’s disease (MCI/AD) and assess the effect of gray matter (GM) atrophy on stimulation outcomes. Methods: Twenty MCI/AD patients participated in the proof-of-concept controlled study. Each patient received three sessions of 10 Hz rTMS of the right inferior frontal gyrus (IFG), the right superior temporal gyrus (STG), and the vertex (VTX, a control stimulation site) in a randomized order. Cognitive functions were tested prior to and immediately after each session. The GM volumetric data of patients were: 1)compared to healthy controls (HC) using source-based morphometry; 2) correlated with rTMS-induced cognitive improvement. Results: The effect of the stimulated site on the difference in cognitive scores was statistically significant for the Word part of the Stroop test (ST-W, p = 0.012, linear mixed models). As compared to the VTX stimulation, patients significantly improved after both IFG and STG stimulation in this cognitive measure. MCI/AD patients had significant GM atrophy in characteristic brain regions as compared to HC (p = 0.029, Bonferroni corrected). The amount of atrophy correlated with the change in ST-W scores after rTMS of the STG. Conclusion: rTMS enhanced cognitive functions in MCI/AD patients. We demonstrated for the first time that distinct pattern of GM atrophy in MCI/AD diminishes the cognitive effects induced by rTMS of the temporal neocortex.
ER  -

ANDERKOVÁ, Ľubomíra, Ilona ELIÁŠOVÁ, Radek MAREČEK, Eva JANOUŠOVÁ a Irena REKTOROVÁ. Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer’s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation. \textit{JOURNAL OF ALZHEIMERS DISEASE}. AMSTERDAM: IOS PRESS, 2015, roč.~48, č.~1, s.~251-260. ISSN~1387-2877. Dostupné z: https://dx.doi.org/10.3233/JAD-150067.

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