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@article{1305229, author = {Anderková, Ľubomíra and Eliášová, Ilona and Mareček, Radek and Janoušová, Eva and Rektorová, Irena}, article_location = {AMSTERDAM}, article_number = {1}, doi = {http://dx.doi.org/10.3233/JAD-150067}, keywords = {noninvasive brain stimulation; Alzheimer's disease; cognitive functions; brain atrophy; source-based morphometry}, language = {eng}, issn = {1387-2877}, journal = {JOURNAL OF ALZHEIMERS DISEASE}, title = {Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer’s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation}, url = {http://content.iospress.com/articles/journal-of-alzheimers-disease/jad150067}, volume = {48}, year = {2015} }
TY - JOUR ID - 1305229 AU - Anderková, Ľubomíra - Eliášová, Ilona - Mareček, Radek - Janoušová, Eva - Rektorová, Irena PY - 2015 TI - Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer’s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation JF - JOURNAL OF ALZHEIMERS DISEASE VL - 48 IS - 1 SP - 251-260 EP - 251-260 PB - IOS PRESS SN - 13872877 KW - noninvasive brain stimulation KW - Alzheimer's disease KW - cognitive functions KW - brain atrophy KW - source-based morphometry UR - http://content.iospress.com/articles/journal-of-alzheimers-disease/jad150067 L2 - http://content.iospress.com/articles/journal-of-alzheimers-disease/jad150067 N2 - Background: Repetitive transcranial magnetic stimulation (rTMS) is a promising tool to study and modulate brain plasticity. Objective: Our aim was to investigate the effects of rTMS on cognitive functions in patients with mild cognitive impairment and Alzheimer’s disease (MCI/AD) and assess the effect of gray matter (GM) atrophy on stimulation outcomes. Methods: Twenty MCI/AD patients participated in the proof-of-concept controlled study. Each patient received three sessions of 10 Hz rTMS of the right inferior frontal gyrus (IFG), the right superior temporal gyrus (STG), and the vertex (VTX, a control stimulation site) in a randomized order. Cognitive functions were tested prior to and immediately after each session. The GM volumetric data of patients were: 1)compared to healthy controls (HC) using source-based morphometry; 2) correlated with rTMS-induced cognitive improvement. Results: The effect of the stimulated site on the difference in cognitive scores was statistically significant for the Word part of the Stroop test (ST-W, p = 0.012, linear mixed models). As compared to the VTX stimulation, patients significantly improved after both IFG and STG stimulation in this cognitive measure. MCI/AD patients had significant GM atrophy in characteristic brain regions as compared to HC (p = 0.029, Bonferroni corrected). The amount of atrophy correlated with the change in ST-W scores after rTMS of the STG. Conclusion: rTMS enhanced cognitive functions in MCI/AD patients. We demonstrated for the first time that distinct pattern of GM atrophy in MCI/AD diminishes the cognitive effects induced by rTMS of the temporal neocortex. ER -
ANDERKOVÁ, Ľubomíra, Ilona ELIÁŠOVÁ, Radek MAREČEK, Eva JANOUŠOVÁ a Irena REKTOROVÁ. Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer’s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation. \textit{JOURNAL OF ALZHEIMERS DISEASE}. AMSTERDAM: IOS PRESS, 2015, roč.~48, č.~1, s.~251-260. ISSN~1387-2877. Dostupné z: https://dx.doi.org/10.3233/JAD-150067.
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